The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
Open accessAbstract
Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues of intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. Immunodepletion of Cdc6 by microinjection of anti-Cdc6 antibody blocks initiation of DNA replication in a human tumor cell line. We conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Cited by
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A
Meraldi, P., Lukas, J., Fry, A. M., Bartek, J., & Nigg, E. A. (1999) · Nature Cell Biology · doi:10.1038/10054 · Cited by 475
Davis, A. J., Yan, Z., Martinez, B., & Mumby, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710313200 · Cited by 45
Self-citationEelen, G., Vanden Bempt, I., Verlinden, L., Drijkoningen, M., Smeets, A., Neven, P., Christiaens, M. R., Marchal, K., Bouillon, R., & Verstuyf, A. (2008) · Oncogene · doi:10.1038/onc.2008.51 · Cited by 41
Metadata
- Authors
- Yan, Z., DeGregori, J., Shohet, R., Leone, G., Stillman, B., Nevins, J. R., & Williams, R. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-31
- Volume
- 95
- Issue
- 7
- Pages
- 3603-3608
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052381578
- Cited by
- 266
- References
- 2
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. https://app.cochat.ai/papers/10.1073/pnas.95.7.3603
- The paper
- Yan, Z., DeGregori, J., Shohet, R., Leone, G., Stillman, B., Nevins, J. R., & Williams, R. S. (1998). Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.7.3603
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
