The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body
Open accessAbstract
The cellular role of the PML-containing nuclear bodies also known as ND10 or PODs remains elusive despite links to oncogenesis and viral replication. Although a potential role in transcription has been considered, direct evidence has been lacking. By developing a novel in vivo nucleic acid labeling approach, we demonstrate the existence of nascent RNA polymerase II transcripts within this nuclear body. In addition, PML and the transactivation cofactor, CREB binding protein (CBP), colocalize within the nucleus. Furthermore, we show that CBP in contrast to PML is distributed throughout the internal core of the structure. Collectively, these findings support a role for this nuclear body in transcriptional regulation.
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Citations
Cites
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533
Cited by
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Ishov, A. M., Sotnikov, A. G., Negorev, D., Vladimirova, O. V., Neff, N., Kamitani, T., Yeh, E. T. H., Strauss, J. F., & Maul, G. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.221 · Cited by 832
Wu, L., Aster, J. C., Blacklow, S. C., Lake, R., Artavanis-Tsakonas, S., & Griffin, J. D. (2000) · Nature Genetics · doi:10.1038/82644 · Cited by 579
PML is induced by oncogenic ras and promotes premature senescence
Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development · doi:10.1101/gad.14.16.2015 · Cited by 536
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis
Saha, R. N., & Pahan, K. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401769 · Cited by 441
Metadata
- Authors
- LaMorte, V. J., Dyck, J. A., Ochs, R. L., & Evans, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-04-28
- Volume
- 95
- Issue
- 9
- Pages
- 4991-4996
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047119203
- Cited by
- 239
- References
- 2
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. https://app.cochat.ai/papers/10.1073/pnas.95.9.4991
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- LaMorte, V. J., Dyck, J. A., Ochs, R. L., & Evans, R. M. (1998). Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.9.4991
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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