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A paracrine role for the epithelial progesterone receptor in mammary gland development
Open accessAbstract
Recently generated progesterone receptor (PR)-negative (PR −/− ) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. However, the full extent of the mammary gland defect in these mice caused by the absence of the PR cannot be assessed, because PR −/− mice do not exhibit estrous cycles and fail to become pregnant. To circumvent this difficulty, we have transplanted PR −/− breasts into wild-type mice, and we have demonstrated that the development of the mammary gland in the absence of the PR is arrested at the stage of the simple ductal system found in the young virgin mouse. Mammary transplants lacking the PR in the stromal compartment give rise to normal alveolar growth, whereas transplants containing PR −/− epithelium conserve the abnormal phenotype. Chimeric epithelia in which PR −/− cells are in close vicinity to PR wild-type cells go through complete alveolar development to which the PR −/− cells contribute. Together, these results indicate that progesterone acts by a paracrine mechanism on a subset of mammary epithelial cells to allow for alveolar growth and that expression of the PR is not required in all the cells of the mammary epithelium in order for alveolar development to proceed normally.
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Cited by
Control of mammary stem cell function by steroid hormone signalling
Asselin-Labat, M.-L., Vaillant, F., Sheridan, J. M., Pal, B., Wu, D., Simpson, E. R., Yasuda, H., Smyth, G. K., Martin, T. J., Lindeman, G. J., et al. (2010) · Nature · doi:10.1038/nature09027 · Cited by 693
Breast milk, a source of beneficial microbes and associated benefits for infant health
Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520
β-Catenin and Tcfs in Mammary Development and Cancer
Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1025944723047 · Cited by 209
Tissue remodelling through branching morphogenesis
Affolter, M., Zeller, R., & Caussinus, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2797 · Cited by 185
Metadata
- Authors
- Brisken, C., Park, S., Vass, T., Lydon, J. P., O’Malley, B. W., & Weinberg, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-04-28
- Volume
- 95
- Issue
- 9
- Pages
- 5076-5081
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036638605
- Cited by
- 479
- References
- 0
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A paracrine role for the epithelial progesterone receptor in mammary gland development. https://app.cochat.ai/papers/10.1073/pnas.95.9.5076
- The paper
- Brisken, C., Park, S., Vass, T., Lydon, J. P., O’Malley, B. W., & Weinberg, R. A. (1998). A paracrine role for the epithelial progesterone receptor in mammary gland development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.9.5076
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
