The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
DNA methylation is a reversible biological signal
Open accessAbstract
The pattern of DNA methylation plays an important role in regulating different genome functions. To test the hypothesis that DNA methylation is a reversible biochemical process, we purified a DNA demethylase from human cells that catalyzes the cleavage of a methyl residue from 5-methyl cytosine and its release as methanol. We show that similar to DNA methyltransferase, DNA demethylase shows CpG dinucleotide specificity, can demethylate mdCpdG sites in different sequence contexts, and demethylates both fully methylated and hemimethylated DNA. Thus, contrary to the commonly accepted model, DNA methylation is a reversible signal, similar to other physiological biochemical modifications.
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Cites
DNA Methylation and Gene Function
Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,071
High sensitivity mapping of methylated cytosines
Susan, J. C., Harrison, J., Paul, C. L., & Frommer, M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.2990 · Cited by 1,862
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
Nan, X., Campoy, F. J., & Bird, A. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,275
Monk, M., Boubelik, M., & Lehnert, S. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,094
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells
Bestor, T., Laudano, A., Mattaliano, R., & Ingram, V. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913
Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation
Mohandas, T., Sparkes, R. S., & Shapiro, L. J. (1981) · Science · doi:10.1126/science.6164095 · Cited by 709
A mammalian protein with specific demethylase activity for mCpG DNA
Bhattacharya, S. K., Ramchandani, S., Cervoni, N., & Szyf, M. (1999) · Nature · doi:10.1038/17533 · Cited by 620
Self-citationSubstrate and sequence specificity of a eukaryotic DNA methylase
Gruenbaum, Y., Cedar, H., & Razin, A. (1982) · Nature · doi:10.1038/295620a0 · Cited by 427
Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency
Bugge, T. H., Kombrinck, K. W., Flick, M. J., Daugherty, C. C., Danton, M. J. S., & Degen, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81390-2 · Cited by 424
Role of DNA methylation in the regulation of transcription
Eden, S., & Cedar, H. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80052-8 · Cited by 320
Cited by
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Meaney, M. J., & Szyf, M. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.2/mmeaney · Cited by 958
Maternal care as a model for experience-dependent chromatin plasticity?
Meaney, M. J., & Szyf, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.006 · Cited by 658
The social environment and the epigenome
Szyf, M., McGowan, P., & Meaney, M. J. (2008) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20357 · Cited by 531
Self-citationMolecular and Therapeutic Potential and Toxicity of Valproic Acid
Chateauvieux, S., Morceau, F., Dicato, M., & Diederich, M. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/479364 · Cited by 512
Metadata
- Authors
- Ramchandani, S., Bhattacharya, S. K., Cervoni, N., & Szyf, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-25
- Volume
- 96
- Issue
- 11
- Pages
- 6107-6112
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052665087
- Cited by
- 340
- References
- 28
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Ramchandani, S., Bhattacharya, S. K., Cervoni, N., & Szyf, M. (1999). DNA methylation is a reversible biological signal. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.11.6107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
