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Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene
Open accessAbstract
The Arabidopsis thaliana NPR1 has been shown to be a key regulator of gene expression during the onset of a plant disease-resistance response known as systemic acquired resistance. The npr1 mutant plants fail to respond to systemic acquired resistance-inducing signals such as salicylic acid (SA), or express SA-induced pathogenesis-related ( PR ) genes. Using NPR1 as bait in a yeast two-hybrid screen, we identified a subclass of transcription factors in the basic leucine zipper protein family (AHBP-1b and TGA6) and showed that they interact specifically in yeast and in vitro with NPR1. Point mutations that abolish the NPR1 function in A. thaliana also impair the interactions between NPR1 and the transcription factors in the yeast two-hybrid assay. Furthermore, a gel mobility shift assay showed that the purified transcription factor protein, AHBP-1b, binds specifically to an SA-responsive promoter element of the A. thaliana PR-1 gene. These data suggest that NPR1 may regulate PR-1 gene expression by interacting with a subclass of basic leucine zipper protein transcription factors.
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Citations
Cited by
Durrant, W. E., & Dong, X. (2004) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.42.040803.140421 · Cited by 3,184
Self-citationSystemic Acquired Resistance: Turning Local Infection into Global Defense
Fu, Z. Q., & Dong, X. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105606 · Cited by 1,524
Self-citationTranscription factors in plant defense and stress responses
Singh, K. (2002) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(02)00289-3 · Cited by 1,381
Role of DREB transcription factors in abiotic and biotic stress tolerance in plants
Agarwal, P. K., Agarwal, P., Reddy, M. K., & Sopory, S. K. (2006) · Plant Cell Reports · doi:10.1007/s00299-006-0204-8 · Cited by 1,050
Liu, Y., Schiff, M., Marathe, R., & Dinesh‐Kumar, S. P. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01297.x · Cited by 1,042
Metadata
- Authors
- Zhang, Y., Fan, W., Kinkema, M., Li, X., & Dong, X.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-25
- Volume
- 96
- Issue
- 11
- Pages
- 6523-6528
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966975589
- Cited by
- 714
- References
- 0
- FWCI
- 42.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. https://app.cochat.ai/papers/10.1073/pnas.96.11.6523
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- Zhang, Y., Fan, W., Kinkema, M., Li, X., & Dong, X. (1999). Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.11.6523
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