The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
Open accessAbstract
NFAT transcription factors are related to NF-κB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have identified an NFAT-related protein, NFAT5, which differs from the conventional NFAT proteins NFAT1–4 in its structure, DNA binding, and regulation. NFAT5 contains a NFAT-like Rel homology domain, conserves the DNA contact residues of NFAT1–4, and binds DNA sequences similar to those found in the regulatory regions of well-characterized NFAT-dependent genes. However, it lacks the majority of Fos/Jun contact residues and does not bind cooperatively with Fos and Jun to DNA. Unlike NFAT1–4, whose nuclear import is tightly regulated by calcineurin-mediated dephosphorylation, NFAT5 is a constitutively nuclear phosphoprotein regardless of calcineurin activation. These features suggest that unlike the conventional NFAT proteins, NFAT1–4, which activate gene transcription by integrating inputs from calcium/calcineurin and protein kinase C/mitogen-activated protein kinase signaling pathways, NFAT5 participates in as-yet-unidentified signaling pathways in diverse immune and nonimmune cells.
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Cites
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,603
Self-citationA Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J.-R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
The mechanism of action of cyclosporin A and FK506
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Generic Signals and Specific Outcomes
Crabtree, G. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80571-1 · Cited by 731
Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction
Sigal, N. H., & Dumont, F. J. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002511 · Cited by 669
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
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SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES
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The transcription factor NF-ATc is essential for cardiac valve formation
Ranger, A. M., Grusby, M. J., Hodge, M. R., Gravallese, E. M., de la Brousse, F. C., Hoey, T., Mickanin, C., Baldwin, H. S., & Glimcher, L. H. (1998) · Nature · doi:10.1038/32426 · Cited by 586
Cited by
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991
Self-citationPhysiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a
Hernández, G. L., Volpert, O. V., Íñiguez, M. A., Lorenzo, E., Martínez-Martínez, S., Grau, R., Fresno, M., & Redondo, J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.607 · Cited by 432
NFAT control of immune function: New Frontiers for an Abiding Trooper
Vaeth, M., & Feske, S. (2018) · F1000Research · doi:10.12688/f1000research.13426.1 · Cited by 191
Kim, N., Choi, S., Han, E., Hong, B., Choi, S. Y., Kwon, H. M., Hwang, S., Cho, C., & Kim, W. (2014) · European Journal of Immunology · doi:10.1002/eji.201343669 · Cited by 48
Metadata
- Authors
- López-Rodríguez, C., Aramburu, J., Rakeman, A. S., & Rao, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-22
- Volume
- 96
- Issue
- 13
- Pages
- 7214-7219
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074475161
- Cited by
- 373
- References
- 40
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- green
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- López-Rodríguez, C., Aramburu, J., Rakeman, A. S., & Rao, A. (1999). NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.13.7214
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