The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a
Open accessAbstract
Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family, interfering with the induction of cytokines and other inducible genes required for the immune response. Here we show that CsA inhibits migration of primary endothelial cells and angiogenesis induced by vascular endothelial growth factor (VEGF); this effect appears to be mediated through the inhibition of cyclooxygenase (Cox)-2, the transcription of which is activated by VEGF in primary endothelial cells. Consistent with this, we show that the induction of Cox-2 gene expression by VEGF requires NFAT activation. Most important, the CsA-mediated inhibition of angiogenesis both in vitro and in vivo was comparable to the Cox-2 inhibitor NS-398, and reversed by prostaglandin E2. Furthermore, the in vivo corneal angiogenesis induced by VEGF, but not by basic fibroblast growth factor, was selectively inhibited in mice treated with CsA systemically. These findings involve NFAT in the regulation of Cox-2 in endothelial cells, point to a role for this transcription factor in angiogenesis, and may provide a novel mechanism underlying the beneficial effects of CsA in angiogenesis-related diseases such as rheumatoid arthritis and psoriasis.
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Cites
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Cited by
Transcriptional regulation by calcium, calcineurin, and NFAT
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The parallel lives of angiogenesis and immunosuppression: cancer and other tales
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Metadata
- Authors
- Hernández, G. L., Volpert, O. V., Íñiguez, M. A., Lorenzo, E., Martínez-Martínez, S., Grau, R., Fresno, M., & Redondo, J. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-03-05
- Volume
- 193
- Issue
- 5
- Pages
- 607-620
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2170935967
- Cited by
- 432
- References
- 62
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a. https://app.cochat.ai/papers/10.1084/jem.193.5.607
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- Hernández, G. L., Volpert, O. V., Íñiguez, M. A., Lorenzo, E., Martínez-Martínez, S., Grau, R., Fresno, M., & Redondo, J. M. (2001). Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.193.5.607
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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