The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The mast cell tumor necrosis factor α response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48
Open accessAbstract
Mast cells are well known for their harmful role in IgE-mediated hypersensitivity reactions, but their physiological role remains a mystery. Several recent studies have reported that mast cells play a critical role in innate immunity in mice by releasing tumor necrosis factor α (TNF-α) to recruit neutrophils to sites of enterobacterial infection. In some cases, the mast cell TNF-α response was triggered when these cells directly bound FimH on the surface of Escherichia coli. We have identified CD48, a glycosylphosphatidylinositol-anchored molecule, to be the complementary FimH-binding moiety in rodent mast cell membrane fractions. We showed that (i) pretreatment of mast cell membranes with antibodies to CD48 or phospholipase C inhibited binding of FimH+E. coli, (ii) FimH+E. coli but not a FimH−derivative bound isolated CD48 in a mannose-inhibitable manner, (iii) binding of FimH+bacteria to Chinese hamster ovary (CHO) cells was markedly increased when these cells were transfected with CD48 cDNA, and (iv) antibodies to CD48 specifically blocked the mast cell TNF-α response to FimH+E. coli.Thus, CD48 is a functionally relevant microbial receptor on mast cells that plays a role in triggering inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989
Malaviya, R., Ikeda, T., Ross, E., & Abraham, S. N. (1996) · Nature · doi:10.1038/381077a0 · Cited by 1,123
Self-citationNew Concepts about the Mast Cell
Flier, J. S., Underhill, L. H., & Galli, S. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280408 · Cited by 990
Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
Low, M. G., & Saltiel, A. R. (1988) · Science · doi:10.1126/science.3276003 · Cited by 952
Critical protective role of mast cells in a model of acute septic peritonitis
Echtenacher, B., Männel, D. N., & Hültner, L. (1996) · Nature · doi:10.1038/381075a0 · Cited by 926
LPS-binding proteins and receptors
Fenton, M. J., & Golenbock, D. T. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.1.25 · Cited by 477
The structure and ligand interactions of CD2: implications for T-cell function
Davis, S. J., & van der Merwe, P. A. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80617-7 · Cited by 391
Self-citationWu, X. R., Sun, T. T., & Medina, J. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9630 · Cited by 342
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic
Baorto, D. M., Gao, Z., Malaviya, R., Dustin, M. L., van der Merwe, A., Lublin, D. M., & Abraham, S. N. (1997) · Nature · doi:10.1038/39376 · Cited by 303
Self-citation
Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
Mast cell-orchestrated immunity to pathogens
Abraham, S. N., & St. John, A. L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2782 · Cited by 837
Self-citationGalli, S. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00007 · Cited by 521
Di Nardo, A., Vitiello, A., & Gallo, R. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2274 · Cited by 405
Álvarez-Twose, I., González de Olano, D., Sánchez-Muñoz, L., Matito, A., Esteban-López, M. I., Vega, A., Mateo, M. B., Alonso Díaz de Durana, M. D., de la Hoz, B., del Pozo Gil, M. D., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.019 · Cited by 294
Metadata
- Authors
- Malaviya, R., Gao, Z., Thankavel, K., van der Merwe, P. A., & Abraham, S. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-07-06
- Volume
- 96
- Issue
- 14
- Pages
- 8110-8115
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081019830
- Cited by
- 255
- References
- 33
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The mast cell tumor necrosis factor α response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. https://app.cochat.ai/papers/10.1073/pnas.96.14.8110
- The paper
- Malaviya, R., Gao, Z., Thankavel, K., van der Merwe, P. A., & Abraham, S. N. (1999). The mast cell tumor necrosis factor α response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.14.8110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
