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Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
Open accessAbstract
Chromosomes are replicated in characteristic, temporal patterns during S phase. We have compared the timing of association of replication proteins at early- and late-replicating origins of replication. Minichromosome maintenance proteins assemble simultaneously at early- and late-replicating origins. In contrast, Cdc45p association with late origins is delayed relative to early origins. DNA polymerase α association is similarly delayed at late origins and requires Cdc45p function. Activation of the S phase checkpoint inhibits association of Cdc45p with late-firing origins. These studies suggest that Cdc45p is poised to serve as a key regulatory target for both the temporal and checkpoint-mediated regulation of replication origins.
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Citations
Cited by
DNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,060
Self-citationMoyer, S. E., Lewis, P. W., & Botchan, M. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602400103 · Cited by 699
Eukaryotic DNA replication origins: many choices for appropriate answers
Méchali, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2976 · Cited by 440
Initiation of Eukaryotic DNA Replication
Walter, J., & Newport, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80241-5 · Cited by 425
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 401
Metadata
- Authors
- Aparicio, O. M., Stout, A. M., & Bell, S. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-08-03
- Volume
- 96
- Issue
- 16
- Pages
- 9130-9135
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2103646786
- Cited by
- 244
- References
- 0
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Aparicio, O. M., Stout, A. M., & Bell, S. P. (1999). Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.16.9130
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