The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
c- fos -induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro
Open accessAbstract
c- fos -induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D) is a secreted factor of the VEGF family that binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3. Here we report that Figf/Vegf-D is a potent angiogenic factor in rabbit cornea in vivo in a dose-dependent manner. In vitro Figf/Vegf-D induces tyrosine phosphorylation of VEGFR-2 and VEGFR-3 in primary human umbilical cord vein endothelial cells (HUVECs) and in an immortal cell line derived from Kaposi’s sarcoma lesion (KS-IMM). The treatment of HUVECs with Figf/Vegf-D induces dose-dependent cell growth. Figf/VEGF-D also induces HUVEC elongation and branching to form an extensive network of capillary-like cords in three-dimensional matrix. In KS-IMM cells Figf/Vegf-D treatment results in dose-dependent mitogenic and motogenic activities. Taken together with the previous observations that Figf/Vegf-D expression is under the control of the nuclear oncogene c- fos , our data uncover a link between a nuclear oncogene and angiogenesis, suggesting that Figf/Vegf-D may play a critical role in tumor cell growth and invasion.
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Cites
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Cited by
Vascular endothelial growth factors and angiogenesis in eye disease
Witmer, A. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00043-5 · Cited by 927
Makinen, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4762 · Cited by 845
Mechanisms of normal and tumor-derived angiogenesis
Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
AP-1 in mouse development and tumorigenesis
Jochum, W., Passegué, E., & Wagner, E. F. (2001) · Oncogene · doi:10.1038/sj.onc.1204389 · Cited by 733
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Metadata
- Authors
- Marconcini, L., Marchiò, S., Morbidelli, L., Cartocci, E., Albini, A., Ziche, M., Bussolino, F., & Oliviero, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-08-17
- Volume
- 96
- Issue
- 17
- Pages
- 9671-9676
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043630178
- Cited by
- 276
- References
- 49
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Marconcini, L., Marchiò, S., Morbidelli, L., Cartocci, E., Albini, A., Ziche, M., Bussolino, F., & Oliviero, S. (1999). c- fos -induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.17.9671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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