CoChat
Sign Up
Cited by 442

CoREST: A functional corepressor required for regulation of neural-specific gene expression

Andrés, María E., Burger, Corinna, Peral-Rubio, María J., Battaglioli, Elena, Anderson, Mary E., Grimes, Julia, Dallman, Julia, Ballas, Nurit +1 more·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.17.9873
Open this paper in CoChat — free account

Abstract

Several genes encoding proteins critical to the neuronal phenotype, such as the brain type II sodium channel gene, are expressed to high levels only in neurons. This cell specificity is due, in part, to long-term repression in nonneural cells mediated by the repressor protein REST/NRSF (RE1 silencing transcription factor/neural-restrictive silencing factor). We show here that CoREST, a newly identified human protein, functions as a corepressor for REST. A single zinc finger motif in REST is required for CoREST interaction. Mutations of the motif that disrupt binding also abrogate repression. When fused to a Gal4 DNA-binding domain, CoREST functions as a repressor. CoREST is present in cell lines that express REST, and the proteins are found in the same immunocomplex. CoREST contains two SANT (SW13/ADA2/NCoR/TFIIIB B) domains, a structural feature of the nuclear receptor and silencing mediator for retinoid and thyroid human receptors (SMRT)-extended corepressors that mediate inducible repression by steroid hormone receptors. Together, REST and CoREST mediate repression of the type II sodium channel promoter in nonneural cells, and the REST/CoREST complex may mediate long-term repression essential to maintenance of cell identity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.96.17.9873

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Once in the nucleus, REST can bind RE1 consensus sequences and recruit co-repressors including mSin3, CoREST, and MeCP2 to inactivate neuron-specific genes.

    “Once in the nucleus, REST can bind RE1 consensus sequences and recruit co-repressors including mSin3, the co-repressor of REST (CoREST, also known as RCOR1) and methyl CpG binding protein 2 (MeCP2) (Andres et al., 1999) to inactivate neuron-specific genes (Zuccato et al., 2003; Conaco et al., 2006).”

    From The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease (2008) · cites this paper as Andres et al., 1999

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. [3]Schoenherr, C. J., Paquette, A. J. & Anderson, D. J. (1996) Proc. Natl. Acad. Sci. USA 93, 9881-9886.
  2. [6]Tapia-Ramı ´rez, J., Eggen, B. J., Peral-Rubio, M. J., Toledo-Aral, J. J. & Mandel, G. (1997) Proc. Natl. Acad. Sci. USA 94, 1177-1182.
  3. [12]Harlow, E. & Lane, D. (1995) Antibodies: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
  4. [17]Park, E. J., Schroen, D. J., Yang, M., Li, H., Li, L. & Chen, J. D. (1999) Proc. Natl. Acad. Sci. USA 96, 3519-3524.

Cited by

Sorted by citations

Authors
Andrés, M. E., Burger, C., Peral-Rubio, M. J., Battaglioli, E., Anderson, M. E., Grimes, J., Dallman, J., Ballas, N., & Mandel, G.
Affiliations
Howard Hughes Medical Institute and Department of Neurobiology and Behavior, and Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1999-08-17
Volume
96
Issue
17
Pages
9873-9878
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.96.17.9873
Cited by
442
References
1
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review