MicroRNAs in neuronal function and dysfunction
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain that can regulate neuronal gene expression at the post-transcriptional level. Here, we provide an overview of the role for miRNAs in brain development and function, and review evidence suggesting that dysfunction in miRNA signaling contributes to neurodevelopment disorders such as Rett and fragile X syndromes, as well as complex behavioral disorders including schizophrenia, depression and drug addiction. A better understanding of how miRNAs influence the development of neuropsychiatric disorders may reveal fundamental insights into the causes of these devastating illnesses and offer novel targets for therapeutic development.
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“Even mild abnormal expression in miRNA expression may impair the brain function as shown by the previous studies [13, 14].”
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“…by cell type, developmental stage, and environment, and they are also dynamic, changing in response to stress, drugs, experiences, and hormones (31). miRNAs are abundant in the brain and have crucial roles in neuronal development and differentiation, synaptic plasticity and learning, stress…”
- Authors
- Im, H.-I., & Kenny, P. J.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Kenny, Paul J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 35
- Issue
- 5
- Pages
- 325-334
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3565236
- OpenAlex
- W1996915289
- Cited by
- 399
- References
- 129
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 17 · 2023: 22 · 2022: 22 · 2021: 29 · 2020: 35 · 2019: 30 · 2018: 25 · 2017: 33 · 2016: 40 · 2015: 38 · 2014: 44 · 2013: 27 · 2012: 12
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA025983, DA025983)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microRNA, neuronal function, brain development, post-transcriptional regulation, neurodevelopmental disorders, Rett syndrome, fragile X syndrome, schizophrenia, depression, drug addiction, neuropsychiatric disorders, therapeutic target
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Neurons, MicroRNAs
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