Cited by 399MicroRNA in disease regulationGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

MicroRNAs in neuronal function and dysfunction

Open access
Im, Heh-In, Kenny, Paul J.·2012·Trends in Neurosciences

Abstract

MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain that can regulate neuronal gene expression at the post-transcriptional level. Here, we provide an overview of the role for miRNAs in brain development and function, and review evidence suggesting that dysfunction in miRNA signaling contributes to neurodevelopment disorders such as Rett and fragile X syndromes, as well as complex behavioral disorders including schizophrenia, depression and drug addiction. A better understanding of how miRNAs influence the development of neuropsychiatric disorders may reveal fundamental insights into the causes of these devastating illnesses and offer novel targets for therapeutic development.

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Crossref · 10.1016/j.tins.2012.01.004

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Authors
Im, H.-I., & Kenny, P. J.
Affiliations
Scripps Research Institute (US)
Corresponding author
Kenny, Paul J.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2012-05
Volume
35
Issue
5
Pages
325-334
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1996915289
Cited by
399
References
129
Citations by year
2026: 15 · 2025: 10 · 2024: 17 · 2023: 22 · 2022: 22 · 2021: 29 · 2020: 35 · 2019: 30 · 2018: 25 · 2017: 33 · 2016: 40 · 2015: 38 · 2014: 44 · 2013: 27 · 2012: 12
FWCI
2.89
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA025983, DA025983)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microRNA, neuronal function, brain development, post-transcriptional regulation, neurodevelopmental disorders, Rett syndrome, fragile X syndrome, schizophrenia, depression, drug addiction, neuropsychiatric disorders, therapeutic target
MeSH terms
Animals, Brain, Gene Expression Regulation, Humans, Neurons, MicroRNAs

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