Canalizing cell fate by transcriptional repression
Open accessAbstract
Precision in the establishment and maintenance of cellular identities is crucial for the development of multicellular organisms and requires tight regulation of gene expression. While extensive research has focused on understanding cell type-specific gene activation, the complex mechanisms underlying the transcriptional repression of alternative fates are not fully understood. Here, we provide an overview of the repressive mechanisms involved in cell fate regulation. We discuss the molecular machinery responsible for suppressing alternative fates and highlight the crucial role of sequence-specific transcription factors (TFs) in this process. Depletion of these TFs can result in unwanted gene expression and increased cellular plasticity. We suggest that these TFs recruit cell type-specific repressive complexes to their cis-regulatory elements, enabling them to modulate chromatin accessibility in a context-dependent manner. This modulation effectively suppresses master regulators of alternative fate programs and their downstream targets. The modularity and dynamic behavior of these repressive complexes enables a limited number of repressors to canalize and maintain major and minor cell fate decisions at different stages of development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Repressive TFs have critical roles in safeguarding cell fate by preventing unwanted plasticity.
“Mounting evidence suggests that repressive TFs also have critical roles in safeguarding cell fate by preventing unwanted plasticity9.”
From Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis (2025) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: New Dimensions
Hanahan, D. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1059 · Cited by 9,887 · see citing works
Regulation of chromatin by histone modifications
Bannister, A. J., & Kouzarides, T. (2011) · Cell Research · doi:10.1038/cr.2011.22 · Cited by 6,012 · see citing works
The Human Transcription Factors
Lambert, S. A., Jolma, A., Campitelli, L. F., Das, P. K., Yin, Y., Albu, M., Chen, X., Taipale, J., Hughes, T. R., & Weirauch, M. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.029 · Cited by 3,399 · see citing works
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388 · see citing works
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533 · see citing works
ChIP–seq: advantages and challenges of a maturing technology
Park, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2641 · Cited by 2,217 · see citing works
CUT&Tag for efficient epigenomic profiling of small samples and single cells
Kaya-Okur, H. S., Wu, S. J., Codomo, C. A., Pledger, E. S., Bryson, T. D., Henikoff, J. G., Ahmad, K., & Henikoff, S. (2019) · Nature Communications · doi:10.1038/s41467-019-09982-5 · Cited by 2,187 · see citing works
Efficient proximity labeling in living cells and organisms with TurboID
Branon, T. C., Bosch, J. A., Sanchez, A. D., Udeshi, N. D., Svinkina, T., Carr, S. A., Feldman, J. L., Perrimon, N., & Ting, A. Y. (2018) · Nature Biotechnology · doi:10.1038/nbt.4201 · Cited by 2,174 · see citing works
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites
Skene, P. J., & Henikoff, S. (2017) · eLife · doi:10.7554/elife.21856 · Cited by 1,737 · see citing works
Induction of Ectopic Eyes by Targeted Expression of the <i>eyeless</i> Gene in <i>Drosophila</i>
Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573 · see citing works
Editing DNA Methylation in the Mammalian Genome
Liu, X. S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R. A., & Jaenisch, R. (2016) · Cell · doi:10.1016/j.cell.2016.08.056 · Cited by 1,224 · see citing works
Control of the Embryonic Stem Cell State
Young, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.01.032 · Cited by 1,189 · see citing works
Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4
Cirillo, L. A., Lin, F. R., Cuesta, I., Friedman, D., Jarník, M., & Zaret, K. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00459-8 · Cited by 1,188 · see citing works
CRISPR/Cas9 in Genome Editing and Beyond
Wang, H., Russa, M. F. L., & Qi, L. S. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014607 · Cited by 1,165 · see citing works
Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine
Taylor, S. M., & Jones, P. A. (1979) · Cell · doi:10.1016/0092-8674(79)90317-9 · Cited by 1,114 · see citing works
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111 · see citing works
Schoenherr, C. J., & Anderson, D. J. (1995) · Science · doi:10.1126/science.7871435 · Cited by 1,088 · see citing works
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,060 · see citing works
Weintraub, H. M., Tapscott, S. J., Davis, R. L., Thayer, M. J., Adam, M. A., Lassar, A. B., & Miller, A. D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5434 · Cited by 985 · see citing works
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974 · see citing works
Tools for neuroanatomy and neurogenetics in Drosophila
Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T.-T. B., Misra, S., Murphy, C., Scully, A. L., Carlson, J. W., Wan, K. H., Laverty, T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803697105 · Cited by 974 · see citing works
Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
Marquardt, T., Ashery‐Padan, R., Andrejewski, N., Scardigli, R., Guillemot, F., & Gruß, P. (2001) · Cell · doi:10.1016/s0092-8674(01)00295-1 · Cited by 926 · see citing works
MicroRNA-mediated conversion of human fibroblasts to neurons
Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien, R. W., & Crabtree, G. R. (2011) · Nature · doi:10.1038/nature10323 · Cited by 919 · see citing works
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works
Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming
Soufi, A., Garcia, M. F., Jaroszewicz, A., Osman, N., Pellegrini, M., & Zaret, K. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.017 · Cited by 780 · cited 1× · see citing works
“…target gene activation induced by master TFs with pioneer function (Foo et al, 2014; Harrison et al, 2011; Iwafuchi-Doi et al, 2016; Lee et al, 2013; Nien et al, 2011; Pan and Schultz, 2011), which can access and open closed chromatin to activate genes (Sou fi et al, 2015; Wapinski et al, 2013).”
BackgroundMicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes
Jayawardena, T. M., Egemnazarov, B., Finch, E., Zhang, L., Payne, J., Pandya, K., Zhang, Z., Rosenberg, P. B., Mirotsou, M., & Dzau, V. J. (2012) · Circulation Research · doi:10.1161/circresaha.112.269035 · Cited by 775 · see citing works
Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates
Laslo, P., Spooner, C. J., Warmflash, A., Lancki, D. W., Lee, H.-J., Sciammas, R., Gantner, B. N., Dinner, A. R., & Singh, H. (2006) · Cell · doi:10.1016/j.cell.2006.06.052 · Cited by 632 · see citing works
Chromatin-modifying enzymes as modulators of reprogramming
Önder, T. T., Kara, N., Cherry, A. B. C., Sinha, A. U., Zhu, N., Bernt, K. M., Cahan, P., Mancarci, B. O., Unternaehrer, J., Gupta, P. B., et al. (2012) · Nature · doi:10.1038/nature10953 · Cited by 627 · see citing works
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., Fuentes, D. R., Giresi, P. G., Ng, Y. H., Marro, S., Neff, N. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.028 · Cited by 627 · see citing works
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615 · see citing works
Proximity labeling in mammalian cells with TurboID and split-TurboID
Cho, K. F., Branon, T. C., Udeshi, N. D., Myers, S. A., Carr, S. A., & Ting, A. Y. (2020) · Nature Protocols · doi:10.1038/s41596-020-0399-0 · Cited by 534 · see citing works
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing
Chen, M., Yao, C., Qin, Y., Cui, X., Li, P., Ji, Z., Lin, L., Wu, H., Zhou, Z., Gui, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00710-4 · Cited by 529 · see citing works
Brand, A. H., Breeden, L. L., Abraham, J. A., Sternglanz, R., & Nasmyth, K. (1985) · Cell · doi:10.1016/0092-8674(85)90059-5 · Cited by 521 · see citing works
Padeken, J., Methot, S. P., & Gasser, S. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00483-w · Cited by 515 · see citing works
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
Lee, M. T., Bonneau, A. R., Takacs, C. M., Bazzini, A., Castellano, K. R., Fleming, E. S., & Giráldez, A. J. (2013) · Nature · doi:10.1038/nature12632 · Cited by 490 · see citing works
The human Mi-2/NuRD complex and gene regulation
Denslow, S. A., & Wade, P. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210611 · Cited by 479 · see citing works
The molecular principles of gene regulation by Polycomb repressive complexes
Blackledge, N. P., & Klose, R. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00398-y · Cited by 470 · see citing works
Multi-omics profiling of mouse gastrulation at single-cell resolution
Argelaguet, R., Clark, S. J., Mohammed, H., Stapel, L. C., Krueger, C., Kapourani, C.-A., Imaz-Rosshandler, I., Lohoff, T., Xiang, Y., Hanna, C. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1825-8 · Cited by 450 · see citing works
CoREST: A functional corepressor required for regulation of neural-specific gene expression
Andrés, M. E., Burger, C., Peral-Rubio, M. J., Battaglioli, E., Anderson, M. E., Grimes, J., Dallman, J., Ballas, N., & Mandel, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9873 · Cited by 442 · see citing works
Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq
Treutlein, B., Lee, Q. Y., Camp, J. G., Mall, M., Koh, W. L. C., Shariati, S. A., Sim, S., Neff, N. F., Skotheim, J. M., Wernig, M., et al. (2016) · Nature · doi:10.1038/nature18323 · Cited by 442 · see citing works
Self-citationA critical role for TCF-1 in T-lineage specification and differentiation
Weber, B., Chi, A. W. S., Chavez, A., Yashiro–Ohtani, Y., Yang, Q., Shestova, O. E., & Bhandoola, A. (2011) · Nature · doi:10.1038/nature10279 · Cited by 420 · see citing works
Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program
Gao, T., McKenna, B. D., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N. M., Zhang, T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.002 · Cited by 412 · see citing works
Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H., & Zaret, K. S. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.001 · Cited by 390 · see citing works
Single-cell mapping of lineage and identity in direct reprogramming
Biddy, B. A., Kong, W., Kamimoto, K., Guo, C., Waye, S. E., Sun, T., & Morris, S. A. (2018) · Nature · doi:10.1038/s41586-018-0744-4 · Cited by 382 · see citing works
Epigenetic control of neural precursor cell fate during development
Hirabayashi, Y., & Gotoh, Y. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2810 · Cited by 376 · see citing works
Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1
Chanda, S., Ang, C. E., Davila, J., Pak, C., Mall, M., Lee, Q. Y., Ahlenius, H., Jung, S. W., Südhof, T. C., & Wernig, M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.05.020 · Cited by 367 · see citing works
Self-citationThe Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
Guo, L., Tian, Y., & Zhu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576946 · Cited by 358 · see citing works
Chromatin repressive complexes in stem cells, development, and cancer
Laugesen, A., & Helin, K. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.05.006 · Cited by 352 · see citing works
Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2Preprint
Plys, A. J., Davis, C. P., Kim, J. J., Rizki, G., Keenen, M. M., Marr, S. K., & Kingston, R. E. (2019) · Genes & Development · doi:10.1101/gad.326488.119 · Cited by 343 · see citing works
Harrison, M. M., Li, X.-Y., Kaplan, T., Botchan, M. R., & Eisen, M. B. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002266 · Cited by 338 · see citing works
Muraoka, N., Yamakawa, H., Miyamoto, K., Sadahiro, T., Umei, T. C., Isomi, M., Nakashima, H., Akiyama, M., Wada, R., Inagawa, K., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201387605 · Cited by 298 · see citing works
Schaffer, A. E., Freude, K., Nelson, S. B., & Sander, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.015 · Cited by 278 · see citing works
Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet
Morris, S. A., Cahan, P., Li, H., Zhao, A., Roman, A. K. S., Shivdasani, R. A., Collins, J. J., & Daley, G. Q. (2014) · Cell · doi:10.1016/j.cell.2014.07.021 · Cited by 267 · see citing works
Generation of neural progenitor cells by chemical cocktails and hypoxia
Cheng, L., Hu, W., Qiu, B., Zhao, J., Yu, Y., Guan, W., Wang, M., Yang, W., & Pei, G. (2014) · Cell Research · doi:10.1038/cr.2014.32 · Cited by 252 · see citing works
The Co-repressor mSin3A Is a Functional Component of the REST-CoREST Repressor Complex
Grimes, J. A., Nielsen, S. J., Battaglioli, E., Miska, E. A., Speh, J. C., Berry, D. L., Atouf, F., Holdener, B. C., Mandel, G., & Kouzarides, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9461 · Cited by 235 · see citing works
A comprehensive library of human transcription factors for cell fate engineering
Ng, A. H. M., Khoshakhlagh, P., Arias, J. E. R., Pasquini, G., Wang, K., Swiersy, A., Shipman, S. L., Appleton, E., Kiaee, K., Kohman, R. E., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0742-6 · Cited by 235 · see citing works
Temporal Coordination of Gene Networks by Zelda in the Early Drosophila Embryo
Nien, C.-Y., Liang, H.-L., Butcher, S. C., Sun, Y., Fu, S., Gocha, T., Kirov, N., Manak, J. R., & Rushlow, C. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002339 · Cited by 234 · see citing works
Revilla‐i‐Domingo, R., Bilić, I., Vilagos, B., Tagoh, H., Ebert, A., Tamir, I., Smeenk, L., Trupke, J., Sommer, A., Jaritz, M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.155 · Cited by 232 · see citing works
Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates
Mall, M., Kareta, M. S., Chanda, S., Ahlenius, H., Perotti, N., Zhou, B., Grieder, S. D., Ge, X., Drake, S., Euong Ang, C., et al. (2017) · Nature · doi:10.1038/nature21722 · Cited by 225 · see citing works
Self-citationMatsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimurâ, H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.010 · Cited by 220 · see citing works
Mazzoni, E. O., Mahony, S., Closser, M., Morrison, C. A., Nedelec, S., Williams, D. J., An, D., Gifford, D. K., & Wichterle, H. (2013) · Nature Neuroscience · doi:10.1038/nn.3467 · Cited by 217 · see citing works
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafishPreprint
Rai, K., Chidester, S., Zavala, C. V., Manos, E. J., James, S. R., Karpf, A. R., Jones, D. A., & Cairns, B. R. (2007) · Genes & Development · doi:10.1101/gad.1472907 · Cited by 201 · see citing works
Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatinPreprint
Johnson, S., Tan, F. J., McCullough, H. L., Riordan, D. P., & Fire, A. Z. (2006) · Genome Research · doi:10.1101/gr.5560806 · Cited by 197 · see citing works
Kareta, M. S., Gorges, L. L., Hafeez, S., Benayoun, B. A., Marro, S. G., Zmoos, A., Cecchini, M. J., Spacek, D. V., Batista, L. F. Z., O’Brien, M., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.10.019 · Cited by 194 · see citing works
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogrammingPreprint
Papizan, J. B., Singer, R. A., Tschen, S.-I., Dhawan, S., Friel, J. M., Hipkens, S. B., Magnuson, M. A., Bhushan, A., & Sussel, L. (2011) · Genes & Development · doi:10.1101/gad.173039.111 · Cited by 193 · see citing works
REST Repression of Neuronal Genes Requires Components of the hSWI·SNF Complex
Battaglioli, E., Andrés, M. E., Rose, D. W., Chenoweth, J. G., Rosenfeld, M. G., Anderson, M. E., & Mandel, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205691200 · Cited by 187 · see citing works
Specifying and protecting germ cell fate
Strome, S., & Updike, D. L. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4009 · Cited by 184 · see citing works
Transcriptional repression in development
Gary, S., & Levin, M. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80010-x · Cited by 184 · see citing works
Candidate silencer elements for the human and mouse genomes
Jayavelu, N. D., Jajodia, A., Mishra, A., & Hawkins, R. D. (2020) · Nature Communications · doi:10.1038/s41467-020-14853-5 · Cited by 180 · see citing works
REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
Dietrich, N., Lerdrup, M., Landt, E., Singh, S. A., Bak, M., Tommerup, N., Rappsilber, J., Södersten, E., & Hansen, K. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002494 · Cited by 173 · see citing works
Decoding gene regulation in the fly brain
Janssens, J., Aibar, S., Taskiran, I. I., Ismail, J. N., Gomez, A. E., Aughey, G., Spanier, K. I., De Rop, F. V., González-Blas, C. B., Dionne, M., et al. (2022) · Nature · doi:10.1038/s41586-021-04262-z · Cited by 170 · see citing works
Decoding gene regulation in the fly brain
Janssens, J., Aibar, S., Taskiran, I. I., Ismail, J. N., Spanier, K. I., Bravo González-Blas, C., Quan, X. J., Papasokrati, D., Hulselmans, G., Makhzami, S., et al. (2021) · doi:10.1101/2021.08.11.454937 · Cited by 170 · see citing works
Nuclear hormone receptor co-repressors: Structure and function
Watson, P. J., Fairall, L., & Schwabe, J. W. R. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.033 · Cited by 164 · see citing works
DNA methylation and the preservation of cell identity
Bogdanović, O., & Lister, R. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.06.007 · Cited by 156 · see citing works
Epigenetic regulation of stem cell fate
Lunyak, V. V., & Rosenfeld, M. G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn149 · Cited by 148 · see citing works
The role of the NK-homeobox gene slouch ( S59 ) in somatic muscle patterning
Knirr, S., Azpiazu, N., & Frasch, M. (1999) · Development · doi:10.1242/dev.126.20.4525 · Cited by 133 · see citing works
Epigenetic regulator function through mouse gastrulation
Grosswendt, S., Kretzmer, H., Smith, Z. D., Kumar, A. S., Hetzel, S., Wittler, L., Klages, S., Timmermann, B., Mukherji, S., & Meissner, A. (2020) · Nature · doi:10.1038/s41586-020-2552-x · Cited by 132 · see citing works
Zelda Potentiates Morphogen Activity by Increasing Chromatin Accessibility
Foo, S. M., Sun, Y., Lim, B., Ziukaite, R., O’Brien, K. M., Nien, C.-Y., Kirov, N., Shvartsman, S. Y., & Rushlow, C. A. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.032 · Cited by 129 · see citing works
Self-citationGisselbrecht, S. S., Palagi, A., Kurland, J. V., Rogers, J. M., Ozadam, H., Zhan, Y., Dekker, J., & Bulyk, M. L. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.10.004 · Cited by 128 · see citing works
Chou, S. T., Khandros, E., Bailey, L. C., Nichols, K., Vakoc, C. R., Yao, Y., Huang, Z., Crispino, J., Hardison, R., Blobel, G., et al. (2009) · Blood · doi:10.1182/blood-2009-03-207944 · Cited by 126 · see citing works
Pioneer factors: roles and their regulation in development
Barral, A., & Zaret, K. S. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.10.007 · Cited by 126 · see citing works
David, L., & Polo, J. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.03.007 · Cited by 125 · see citing works
Hörmanseder, E., Simeone, A., Allen, G. E., Bradshaw, C. R., Figlmüller, M., Gurdon, J. B., & Jullien, J. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.003 · Cited by 120 · see citing works
Myt1 family recruits histone deacetylase to regulate neural transcription
Romm, E., Nielsen, J. A., Kim, J. G., & Hudson, L. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03131.x · Cited by 117 · see citing works
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
Sybirna, A., Tang, W. W. C., Smela, M. P., Dietmann, S., Gruhn, W. H., Brosh, R., & Surani, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15042-0 · Cited by 116 · see citing works
How mammalian transcriptional repressors work
Thiel, G., Lietz, M., & Hohl, M. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04174.x · Cited by 108 · see citing works
GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice
García‐Ojeda, M. E., Wolterink, R. G. J. K., Lemaı̂tre, F., Goff, O. R.-L., Hasan, M., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2013) · Blood · doi:10.1182/blood-2012-06-440065 · Cited by 105 · see citing works
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., Weicksel, S. E., Melchionda, M., Mousavy Gharavy, S. N., Briscoe, J., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003127 · Cited by 96 · see citing works
Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, M., Knoblich, J. A., & van Lohuizen, M. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.93 · Cited by 95 · see citing works
BMP-induced REST regulates the establishment and maintenance of astrocytic identity
Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H., & Nakashima, K. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200908048 · Cited by 94 · see citing works
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01528-8 · Cited by 87 · see citing works
Transcription factor competition at the γ-globin promoters controls hemoglobin switching
Liu, N., Xu, S., Yao, Q., Zhu, Q., Yan, K., Hsu, J. Y., Sakon, P., Pinello, L., Yuan, G., Bauer, D. E., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00798-y · Cited by 86 · see citing works
SOX2 Modulates Reprogramming of Gene Expression in Two-Cell Mouse Embryos1
Pan, H., & Schultz, R. M. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.090886 · Cited by 83 · see citing works
Anderson, A. M., Weasner, B. M., Weasner, B. P., & Kumar, J. P. (2012) · Development · doi:10.1242/dev.077255 · Cited by 80 · see citing works
Transcriptional Repression: Conserved and Evolved Features
Payankaulam, S., Li, L. M., & Arnosti, D. N. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.037 · Cited by 79 · see citing works
Wontakal, S. N., Guo, X., Smith, C., MacCarthy, T., Bresnick, E. H., Bergman, A., Snyder, M. P., Weissman, S. M., Zheng, D., & Skoultchi, A. I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121019109 · Cited by 79 · see citing works
Zhang, K.-K., Chen, S., Yang, Q., Guo, S., Chen, Q., Liu, Z.-X., Li, L., Jiang, M., Li, H.-D., Hu, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29068-z · Cited by 74 · see citing works
Epigenetic Mechanisms of Groucho/Grg/TLE Mediated Transcriptional Repression
Patel, S. R., Bhumbra, S. S., Paknikar, R., & Dressler, G. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.007 · Cited by 74 · see citing works
Lee, S. W., Oh, Y. M., Lu, Y.-L., Kim, W. K., & Yoo, A. S. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.007 · Cited by 73 · see citing works
Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function
Brand, M., Nakka, K. K., Zhu, J., & Dilworth, F. J. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.005 · Cited by 73 · see citing works
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Banerjee, A., Northrup, D. L., Boukarabila, H., Jacobsen, S. E. W., & Allman, D. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.014 · Cited by 72 · see citing works
The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Shen, J., Li, P., Shao, X., Yang, Y., Liu, X., Feng, M., Yu, Q., Hu, R., & Wang, Z. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1805 · Cited by 66 · see citing works
Cheng, H., Shang, D., & Zhou, R. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01197-3 · Cited by 66 · see citing works
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
de Walle, I. V., Dolens, A., Durinck, K., Katrien De Mulder, A., Loocke, W. V., Damle, S. S., Waegemans, E., Medts, J. D., Velghe, I., Smedt, M. D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11171 · Cited by 65 · see citing works
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.009 · Cited by 61 · see citing works
CBX2 is required to stabilize the testis pathway by repressing Wnt signaling
Garcia-Moreno, S. A., Lin, Y.-T., Futtner, C., Salamone, I. M., Capel, B., & Maatouk, D. M. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007895 · Cited by 61 · see citing works
Cell Reprogramming: The Many Roads to Success
Aydın, B., & Mazzoni, E. O. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125127 · Cited by 60 · see citing works
Chanda, S., Ang, C. E., Lee, Q. Y., Ghebrial, M., Haag, D., Shibuya, Y., Wernig, M., & Südhof, T. C. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.04.021 · Cited by 58 · see citing works
Nicol, B., Grimm, S. A., Gruzdev, A., Scott, G. J., Ray, M. K., & Yao, H. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy312 · Cited by 57 · see citing works
Enhancer–silencer transitions in the human genomePreprint
Huang, D., & Ovcharenko, I. (2022) · Genome Research · doi:10.1101/gr.275992.121 · Cited by 57 · see citing works
A high-resolution map of transcriptional repression
Liang, Z., Brown, K. E., Carroll, T., Taylor, B., Vidal, I. F., Hendrich, B., Rueda, D., Fisher, A. G., & Merkenschlager, M. (2017) · eLife · doi:10.7554/elife.22767 · Cited by 54 · see citing works
Chestnut, B., Chetty, S. C., Koenig, A. L., & Sumanas, S. (2020) · Nature Communications · doi:10.1038/s41467-020-16515-y · Cited by 54 · see citing works
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors
Nishi, Y., Zhang, X., Jeong, J., Peterson, K. A., Vedenko, A., Bulyk, M. L., Hide, W. A., & McMahon, A. P. (2015) · Development · doi:10.1242/dev.124636 · Cited by 53 · see citing works
Furlan, A., Lübke, M., Adameyko, I. I., Lallemend, F., & Ernfors, P. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.85 · Cited by 50 · see citing works
Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
Tsyporin, J., Tastad, D., Ma, X., Nehme, A., Finn, T. S., Huebner, L., Liu, G., Gallardo, D., Makhamreh, A. K., Roberts, J. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109269 · Cited by 50 · see citing works
Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes
Lee, Q. Y., Mall, M., Chanda, S., Zhou, B., Sharma, K. S., Schaukowitch, K., Adrian-Segarra, J. M., Grieder, S. D., Kareta, M. S., Wapinski, O. L., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0490-3 · Cited by 50 · see citing works
Self-citationEpigenetics and Cognitive Aging
Sweatt, J. (2010) · Science · doi:10.1126/science.1189968 · Cited by 49 · see citing works
The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
Smolko, A. E., Shapiro-Kulnane, L., & Salz, H. K. (2018) · Nature Communications · doi:10.1038/s41467-018-06697-x · Cited by 46 · see citing works
Korzelius, J., Azami, S., Ronnen-Oron, T., Koch, P., Baldauf, M., Meier, E., Rodriguez‐Fernandez, I. A., Groth, M., Sousa‐Victor, P., & Jasper, H. (2019) · Nature Communications · doi:10.1038/s41467-019-12003-0 · Cited by 45 · see citing works
Repression by PRDM13 is critical for generating precision in neuronal identity
Mona, B., Urueña, A., Kollipara, R., Ma, Z., Borromeo, M. D., Chang, J. C., & Johnson, J. E. (2017) · eLife · doi:10.7554/elife.25787 · Cited by 44 · see citing works
The CBX family of proteins in transcriptional repression and memory
Kim, J. J., & Kingston, R. E. (2020) · Journal of Biosciences · doi:10.1007/s12038-019-9972-5 · Cited by 43 · see citing works
G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst
Żylicz, J. J., Borensztein, M., Wong, F. C. K., Huang, Y., Lee, C. G. L., Dietmann, S., & Surani, M. A. (2018) · eLife · doi:10.7554/elife.33361 · Cited by 41 · see citing works
Lee, N., Park, S. J., Haddad, G., Kim, D., Park, S., Park, S. K., & Choi, K. Y. (2016) · Scientific Reports · doi:10.1038/srep39049 · Cited by 40 · see citing works
A high-resolution map of transcriptional repression
Liang, Z., Brown, K. E., Carroll, T. D., Taylor, B., Ferreirós Vidal, I., Hendrich, B., Rueda, D., Fisher, A. G., & Merkenschlager, M. (2017) · Apollo (University of Cambridge) · doi:10.17863/cam.10112 · Cited by 39 · see citing works
Blocking promiscuous activation at cryptic promoters directs cell type–specific gene expression
Kim, J., Lu, C., Srinivasan, S., Awe, S., Brehm, A., & Fuller, M. T. (2017) · Science · doi:10.1126/science.aal3096 · Cited by 39 · see citing works
Singh, V., Pinnamaneni, J. P., Pugazenthi, A., Sanagasetti, D., Mathison, M. N., Wang, K., Yang, J., & Rosengart, T. K. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015686 · Cited by 37 · see citing works
Zhang, C., Huang, H., Chen, Z., Zhang, Z., Lu, W., & Qiu, M. S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011163 · Cited by 36 · see citing works
Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila
Weasner, B. M., & Kumar, J. P. (2012) · Development · doi:10.1242/dev.085423 · Cited by 35 · see citing works
Neural cell state shifts and fate loss in ageing and age-related diseases
Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 34 · see citing works
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
Rossitto, M., Déjardin, S., Rands, C. M., Gras, S. L., Migale, R., Rafiee, M.-R., Neirijnck, Y., Pruvost, A., Nguyen, A., Bossis, G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32061-1 · Cited by 33 · see citing works
Weigel, B., Tegethoff, J. F., Grieder, S. D., Lim, B., Nagarajan, B., Liu, Y.-C., Truberg, J., Papageorgiou, D., Adrian-Segarra, J. M., Schmidt, L. K., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01959-7 · Cited by 31 · see citing works
Self-citationPivetti, S., Fernández-Pérez, D., D’Ambrosio, A., Barbieri, C., Manganaro, D., Rossi, A., Barnabei, L., Zanotti, M., Scelfo, A., Chiacchiera, F., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav1594 · Cited by 30 · see citing works
Ciglar, L., Girardot, C., Wilczyński, B., Braun, M. M., & Furlong, E. E. M. (2014) · Development · doi:10.1242/dev.101956 · Cited by 28 · see citing works
Information content differentiates enhancers from silencers in mouse photoreceptors
Friedman, R. Z., Granas, D. M., Myers, C. A., Corbo, J. C., Cohen, B. A., & White, M. A. (2021) · eLife · doi:10.7554/elife.67403 · Cited by 28 · see citing works
Domsch, K., Carnesecchi, J., Disela, V., Friedrich, J., Trost, N., Ermakova, O. V., Polychronidou, M., & Lohmann, I. (2019) · eLife · doi:10.7554/elife.42675 · Cited by 26 · see citing works
Self-citationJacob and Monod: From Operons to EvoDevo
Gann, A. A. F. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.027 · Cited by 24 · see citing works
Breunig, C., Köferle, A., Neuner, A. M., Wiesbeck, M. F., Baumann, V., & Stricker, S. H. (2020) · Physiological Reviews · doi:10.1152/physrev.00034.2019 · Cited by 24 · see citing works
Zhu, J., Ordway, A. J., Weber, L., Buddika, K., & Kumar, J. P. (2018) · Development · doi:10.1242/dev.160754 · Cited by 22 · see citing works
PRC1 sustains the integrity of neural fate in the absence of PRC2 function
Sawai, A., Pfennig, S., Bulajić, M., Miller, A., Khodadadi‐Jamayran, A., Mazzoni, E. O., & Dasen, J. S. (2022) · eLife · doi:10.7554/elife.72769 · Cited by 20 · see citing works
Mochizuki, K., Hayashi, Y., Sekinaka, T., Otsuka, K., Ito‐Matsuoka, Y., Kobayashi, H., Oki, S., Takehara, A., Kono, T., Osumi, N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.108 · Cited by 20 · see citing works
Jacobs, J., Pagani, M., Wenzl, C., & Stark, A. (2023) · Science · doi:10.1126/science.adf6149 · Cited by 19 · see citing works
Kim, S., Oh, H., Choi, S. H., Yoo, Y.-E., Noh, Y. W., Cho, Y., Im, G. H., Lee, C., Oh, Y., Yang, E., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111398 · Cited by 19 · see citing works
Klumpfuss is involved in the determination of sensory organ precursors in Drosophila
Kaspar, M., Schneider, M., Chia, W. N., & Klein, T. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.031 · Cited by 18 · see citing works
Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons
Ichida, J. K., Staats, K. A., Davis‐Dusenbery, B. N., Clement, K., Galloway, K. E., Babos, K., Shi, Y., Son, E., Kiskinis, E., Atwater, N., et al. (2018) · Development · doi:10.1242/dev.168617 · Cited by 15 · see citing works
Popkova, A., Bernardoni, R., Diebold, C., Bor, V. V. D., Schuettengruber, B., González, I., Busturia, A., Cavalli, G., & Giangrande, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003159 · Cited by 12 · see citing works
Rest represses maturation within migrating facial branchiomotor neurons
Love, C. E., & Prince, V. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.021 · Cited by 11 · see citing works
Klaus, L., de Almeida, B. P., Vlasova, A. V., Nemčko, F., Schleiffer, A., Bergauer, K., Hofbauer, L., Rath, M., & Stark, A. (2022) · The EMBO Journal · doi:10.15252/embj.2022112100 · Cited by 11 · see citing works
Reuter, A.-S., Stern, D., Bernard, A. M., Goossens, C., Lavergne, A., Flasse, L. C., Berg, V. V., Manfroid, I., Peers, B., & Voz, M. L. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010109 · Cited by 10 · see citing works
Palliyil, S., Zhu, J., Baker, L. R., Neuman, S. D., Bashirullah, A., & Kumar, J. P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007185 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Notch pathway: A guardian of cell fate during neurogenesis
Gonzalez, R. C., & Reinberg, D. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102543 · Cited by 25 · see citing works
Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02081-w · Cited by 17 · see citing works
Self-citationREST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate
Sahinyan, K., Blackburn, D. M., Simon, M.-M., Lazure, F., Kwan, T., Wilson, D. H., Vahidyeganeh, M., Alsadi, N., von Maltzahn, J., Yamada, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62758-y · Cited by 7 · see citing works
prdm1a drives a fate switch between hair cells of different mechanosensory organs
Sandler, J. E., Tsai, Y.-Y., Chen, S., Sabin, L., Lush, M. E., Sur, A., Ellis, E., Tran, N. T. T., Cook, M. E., Scott, A. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62942-0 · Cited by 5 · see citing works
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
Sun, S., Sun, Y., Lan, L., Luan, S., Zhou, J. R., Deng, J., Yuan, Y., & Wu, Z. (2025) · MedComm · doi:10.1002/mco2.70541 · Cited by 6 · see citing works
Priebe, V., Galvan, B., Drakul, A., Margelisch, N., Aguadé-Gorgorió, J., Walavalkar, K., Huang, Y., Mikkola, H. K. A., Bornhauser, B. C., Santoro, R., et al. (2026) · Science Advances · doi:10.1126/sciadv.adu3728 · Cited by 3 · see citing works
A 2026 perspective on neural stem cells and glial plasticity
Puletti, F., Lloret-Fernández, C., Lorenz, A., Cao, C., Poole, R. J., & Azzarelli, R. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.05.001 · Cited by 1 · see citing works
GABAergic neuron fate specification and lineage allocation: from development to disorder
Dvoretskova, E., & Mayer, C. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102504 · Cited by 1 · see citing works
REST/NRSF preserves muscle stem cell identity and survival by repressing alternate cell fatesPreprint
Soleimani, V. D., Sahinyan, K., Blackburn, D. M., Simon, M.-M., Lazure, F., Kwan, T., Wilson, D. H., von Maltzahn, J., Yamada, Y., Jahani‐Asl, A., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4396883/v1 · Cited by 1 · see citing works
Transcription Factors and Signal Transduction
Carlberg, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-68730-3_4
Carlberg, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-68730-3_11
Mall, M., Lopes, M., & Pereira, C. (2024) · Cellular Reprogramming · doi:10.1089/cell.2024.36789.mor
Self-citationSafeguard repressor locks hepatocyte identity and blocks liver cancer
(2025) · Nature Genetics · doi:10.1038/s41588-025-02082-9
Signatures of digital Polycomb regulation in functional iPSC heterogeneity between individualsPreprint
Miangolarra, A. M., Kurlovich, J., Torabi, F., Dovgusha, O., Cao, Y., Lin, L., Günesdogan, U., Schoenfelder, S., & Howard, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.25.666753
Epithelial Reprogramming and Transition during Pulmonary BioengineeringPreprint
Mizoguchi, S., Lee, V., Kim, H., Edelstein, S. E., Wang, N., Gracia, M. T., Danelski, C., Haynes, C. V., Rivero, R., Stitelman, D. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.24.701406
Dnmt1 mediates epigenetic restriction of invasive traits in clonal crayfish
Diaz-Larrosa, J. J., Carneiro, V. C., Hanna, K., Raddatz, G., & Lyko, F. (2026) · Nature Communications · doi:10.1038/s41467-026-71049-z
NuRepress: Inferring Transcriptional Repressors from Phased Nucleosome Architecture
Xiang, Q., & Lai, B. (2026) · Genes · doi:10.3390/genes17040480
Cai, Y., Tang, X., Xia, Q., Wang, H., Liu, L., Ye, C., Liu, B., Wang, W., Duan, P., & Tan, Y. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103809
Liu, Y., Niu, L., Zhang, C., Bao, L., Wang, M., Liu, Q., Liu, H., Hu, Z., Shi, L., Pang, Y., et al. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.105703
- Authors
- Lim, B., Domsch, K., Mall, M., & Lohmann, I.
- Affiliations
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Corresponding author
- Mall, Moritz
- Lohmann, Ingrid
- Venue
- Molecular Systems Biology
- Published
- 2024-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 144-161
- ISSN
- 1744-4292 (ISSN-L)
- PMC
- PMC10912439
- OpenAlex
- W4391435778
- Cited by
- 19
- References
- 149
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 4
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Systems Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (504019642, 514206638, LO 844/8-4)
- EC | ERC | HORIZON EUROPE European Research Council (804710)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- cell fate determination, transcriptional repression, sequence-specific transcription factors, cis-regulatory elements, chromatin accessibility, cellular plasticity, master regulators, cell identity maintenance, developmental gene regulation
- MeSH terms
- Cell Differentiation, Chromatin, Transcription Factors, Transcriptional Activation, Gene Expression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review