The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
Open accessAbstract
Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the retinal damage that characterizes the disease results from retinal vascular leakage and nonperfusion. This study shows that diabetic retinal vascular leakage and nonperfusion are temporally and spatially associated with retinal leukocyte stasis (leukostasis) in the rat model of streptozotocin-induced diabetes. Retinal leukostasis increases within days of developing diabetes and correlates with the increased expression of retinal intercellular adhesion molecule-1 (ICAM-1). ICAM-1 blockade with a mAb prevents diabetic retinal leukostasis and vascular leakage by 48.5% and 85.6%, respectively. These data identify the causal role of leukocytes in the pathogenesis of diabetic retinopathy and establish the potential utility of ICAM-1 inhibition as a therapeutic strategy for the prevention of diabetic retinopathy.
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Cites
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Cited by
Mechanisms of Diabetic Complications
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Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
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Self-citationDiabetic Retinopathy and Diabetic Macular Edema
Ciulla, T. A., Amador, A. G., & Zinman, B. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2653 · Cited by 836
Role of Inflammation in Diabetic Retinopathy
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Metadata
- Authors
- Miyamoto, K., Khosrof, S., Bursell, S.-E., Rohan, R., Murata, T., Clermont, A. C., Aiello, L. P., Ogura, Y., & Adamis, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-09-14
- Volume
- 96
- Issue
- 19
- Pages
- 10836-10841
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102665979
- Cited by
- 788
- References
- 17
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. https://app.cochat.ai/papers/10.1073/pnas.96.19.10836
- The paper
- Miyamoto, K., Khosrof, S., Bursell, S.-E., Rohan, R., Murata, T., Clermont, A. C., Aiello, L. P., Ogura, Y., & Adamis, A. P. (1999). Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.19.10836
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
