The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Retinoid X receptors are essential for early mouse development and placentogenesis
Open accessAbstract
Embryos carrying null mutations of both retinoid X receptors α and β (RXRα −/− /RXRβ −/− mutants) were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormalities. The cause of the lethality appears to be the lack of formation of the labyrinthine zone of the chorioallantoic placenta. In a thorough analysis of mutant conceptuses, we establish that RXRs, through heterodimerization with retinoic acid receptors, are essential for postimplantation embryonic development before placentogenesis. RXRs are also essential for the formation of the chorioallantoic placenta, most probably through RXR/peroxisomal proliferator-activated receptor-γ heterodimers. Interestingly, as a RXR ligand appears dispensable, placentogenesis must be controlled by a yet unknown hormonal ligand(s) activating the heterodimerization partner(s) of RXRs.
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Cites
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
Self-citationAbsence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
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Nuclear Receptors in Sicily: All in the Famiglia
Perlmann, T., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80498-5 · Cited by 148
Cited by
Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500
T HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT
Clagett-Dame, M., & DeLuca, H. F. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102745e · Cited by 461
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse
Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., & Dollé, P. (2001) · Development · doi:10.1242/dev.128.7.1019 · Cited by 420
Self-citation
Metadata
- Authors
- Wendling, O., Chambon, P., & Mark, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-01-19
- Volume
- 96
- Issue
- 2
- Pages
- 547-551
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2151901281
- Cited by
- 181
- References
- 3
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Wendling, O., Chambon, P., & Mark, M. (1999). Retinoid X receptors are essential for early mouse development and placentogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.2.547
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