Retinoic acid signalling during development
Open accessAbstract
Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. The distribution and levels of RA in embryonic tissues are tightly controlled by regulated synthesis through the action of specific retinol and retinaldehyde dehydrogenases and by degradation via specific cytochrome P450s (CYP26s). Recent studies indicate that RA action involves an interplay between diffusion (morphogen-like) gradients and the establishment of signalling boundaries due to RA metabolism, thereby allowing RA to finely control the differentiation and patterning of various stem/progenitor cell populations. Here, we provide an overview of the RA biosynthesis, degradation and signalling pathways and review the main functions of this molecule during embryogenesis.
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With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid.
“With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid [8,9,10].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [10]
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- Authors
- Rhinn, M., & Dollé, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Rhinn, Muriel
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-03-01
- Volume
- 139
- Issue
- 5
- Pages
- 843-858
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2163112976
- Cited by
- 849
- References
- 9
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 44 · 2023: 40 · 2022: 53 · 2021: 58 · 2020: 79 · 2019: 86 · 2018: 67 · 2017: 77 · 2016: 64 · 2015: 62 · 2014: 73 · 2013: 68 · 2012: 16
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Université de Strasbourg
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinoic acid, retinoic acid receptor, embryonic development, retinol dehydrogenase, retinaldehyde dehydrogenase, retinoic acid metabolism, morphogen gradients, stem cell differentiation, cell fate patterning
- MeSH terms
- Alcohol Oxidoreductases, Animals, Brain, Cell Differentiation, Embryo, Mammalian, Gene Expression Regulation, Isoenzymes, Stem Cells, Tretinoin, Signal Transduction, Receptors, Retinoic Acid, Response Elements, Embryonic Development
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