The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Purification of serine racemase: Biosynthesis of the neuromodulator d -serine
Open accessAbstract
High levels of d -serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N -methyl- d -aspartate receptors. In glial cultures of rat cerebral cortex, d -serine is enriched in type II astrocytes and is released upon stimulation with agonists of non- N -methyl- d -aspartate glutamate receptors. The high levels of d -serine in discrete areas of rat brain imply the existence of a biosynthetic pathway. We have purified from rat brain a soluble enzyme that catalyzes the direct racemization of l -serine to d -serine. Purified serine racemase has a molecular mass of 37 kDa and requires pyridoxal 5′-phosphate for its activity. The enzyme is highly selective toward l -serine, failing to racemize any other amino acid tested. Properties such as pH optimum, K m values, and the requirement for pyridoxal phosphate resemble those of bacterial racemases, suggesting that the biosynthetic pathway for d -amino acids is conserved from bacteria to mammalian brain.
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Schell, M. J., Molliver, M. E., & Snyder, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3948 · Cited by 832
Self-citationSchell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415
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The tripartite synapse: roles for gliotransmission in health and disease
Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852
Wolosker, H., Blackshaw, S., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13409 · Cited by 811
Self-citationGlutamatergic mechanisms in schizophrenia
Tsai, G., & Coyle, J. T. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.160735 · Cited by 577
Glial cells in (patho)physiology
Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07664.x · Cited by 561
d‐Amino acids in the brain:d‐serine in neurotransmission and neurodegeneration
Wolosker, H., Dumin, E., Balan, L., & Foltyn, V. N. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06515.x · Cited by 309
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Metadata
- Authors
- Wolosker, H., Sheth, K. N., Takahashi, M., Mothet, J.-P., Brady, R. O., Ferris, C. D., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-01-19
- Volume
- 96
- Issue
- 2
- Pages
- 721-725
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010158663
- Cited by
- 524
- References
- 2
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Wolosker, H., Sheth, K. N., Takahashi, M., Mothet, J.-P., Brady, R. O., Ferris, C. D., & Snyder, S. H. (1999). Purification of serine racemase: Biosynthesis of the neuromodulator d -serine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.2.721
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