The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Developmental regulation of spine motility in the mammalian central nervous system
Open accessAbstract
The function of dendritic spines, postsynaptic sites of excitatory input in the mammalian central nervous system (CNS), is still not well understood. Although changes in spine morphology may mediate synaptic plasticity, the extent of basal spine motility and its regulation and function remains controversial. We investigated spine motility in three principal neurons of the mouse CNS: cerebellar Purkinje cells, and cortical and hippocampal pyramidal neurons. Motility was assayed with time-lapse imaging by using two-photon microscopy of green fluorescent protein-labeled neurons in acute and cultured slices. In all three cell types, dendritic protrusions (filopodia and spines) were highly dynamic, exhibiting a diversity of morphological rearrangements over short (<1-min) time courses. The incidence of spine motility declined during postnatal maturation, but dynamic changes were still apparent in many spines in late-postnatal neurons. Although blockade or induction of neuronal activity did not affect spine motility, disruption of actin polymerization did. We hypothesize that this basal motility of dendritic protrusions is intrinsic to the neuron and underlies the heightened plasticity found in developing CNS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because spine motility rates decrease during development (Dunaevsky et al., 1999; Majewska and Sur, 2003), this measure is a mark of synapse maturation.”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Dunaevsky et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.
Eg, G. (1959) · PubMed · Cited by 1,768
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Jacobson, M. (1978) · Springer eBooks · doi:10.1007/978-1-4757-4951-9 · Cited by 1,218
Harris, K. M., & Kater, S. B. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,020
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletic-Savatic, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,009
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
Self-citationRapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 882
Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1
Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758
Research works printed but not linked: 2
- R Y Cajal Rev Trimest Histol Norm Pat 1, 1–10 (1888).
- E G Gray J Anat 83, 420–433 (1959).
Cited by
Sorted by citations
Items 401–408 of 408
Actin at the Synapse: Contribution to Pre- and Postsynaptic Functions
Liao, D. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-7368-9_10
Silent synapses and postnatal development of the mouse cerebellar cortex
Ho, S. X. (2018) · theses.fr (ABES) · doi:10.70675/4a464e58z3007z4ec1z8259za9aa42e1c20c
Molecular mechanisms underlying the surface organization of the NMDA receptors during development
Bénac, N. (2024) · theses.fr (ABES) · doi:10.70675/e3508a2ezb62ez4f99zb27bz156201271974
Early spinogenesis in postnatally-born hippocampal granule cells
Frey, L., Kirscht, S., Ebert, J., Hanauske, T., Deller, T., Schwarzacher, S. W., & Jungenitz, T. (2026) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2026.1899044
F-actin dynamics in dendritic spines
Koskinen, M. (2014) · Työväentutkimus Vuosikirja
Metadata
- Authors
- Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R.
- Affiliations
- Columbia University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-11-09
- Volume
- 96
- Issue
- 23
- Pages
- 13438-13443
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC23966
- OpenAlex
- W2156678388
- Cited by
- 412
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 21 · 2013: 12 · 2012: 16
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institutes of Health
- National Eye Institute (R01 EY111787)
- National Institute of Neurological Disorders and Stroke (F32NS010370, R01 NS16951, NS10370, R01NS016951)
- National Institute of Environmental Health Sciences (R01ES016951)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic protrusions, filopodia, postnatal development, synaptic plasticity, Purkinje cells, pyramidal neurons, hippocampal neurons, actin polymerization, neuronal activity, dendritic morphology, central nervous system development
- MeSH terms
- Animals, Brain, Dendrites, Luminescent Proteins, Mice, Inbred C57BL, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
