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Cited by 412Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Developmental regulation of spine motility in the mammalian central nervous system

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Dunaevsky, Anna, Tashiro, Ayumu, Majewska, Ania, Mason, Carol, Yuste, Rafael·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.23.13438PMC PMC23966
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Abstract

The function of dendritic spines, postsynaptic sites of excitatory input in the mammalian central nervous system (CNS), is still not well understood. Although changes in spine morphology may mediate synaptic plasticity, the extent of basal spine motility and its regulation and function remains controversial. We investigated spine motility in three principal neurons of the mouse CNS: cerebellar Purkinje cells, and cortical and hippocampal pyramidal neurons. Motility was assayed with time-lapse imaging by using two-photon microscopy of green fluorescent protein-labeled neurons in acute and cultured slices. In all three cell types, dendritic protrusions (filopodia and spines) were highly dynamic, exhibiting a diversity of morphological rearrangements over short (<1-min) time courses. The incidence of spine motility declined during postnatal maturation, but dynamic changes were still apparent in many spines in late-postnatal neurons. Although blockade or induction of neuronal activity did not affect spine motility, disruption of actin polymerization did. We hypothesize that this basal motility of dendritic protrusions is intrinsic to the neuron and underlies the heightened plasticity found in developing CNS.

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  1. R Y Cajal Rev Trimest Histol Norm Pat 1, 1–10 (1888).
  2. E G Gray J Anat 83, 420–433 (1959).

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Metadata

Authors
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R.
Affiliations
Columbia University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1999-11-09
Volume
96
Issue
23
Pages
13438-13443
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.23.13438
PMC
PMC23966
OpenAlex
W2156678388
Cited by
412
References
39
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 21 · 2013: 12 · 2012: 16
FWCI
7.97
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
  • National Institutes of Health
  • National Eye Institute (R01 EY111787)
  • National Institute of Neurological Disorders and Stroke (F32NS010370, R01 NS16951, NS10370, R01NS016951)
  • National Institute of Environmental Health Sciences (R01ES016951)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
dendritic protrusions, filopodia, postnatal development, synaptic plasticity, Purkinje cells, pyramidal neurons, hippocampal neurons, actin polymerization, neuronal activity, dendritic morphology, central nervous system development
MeSH terms
Animals, Brain, Dendrites, Luminescent Proteins, Mice, Inbred C57BL, Green Fluorescent Proteins, Mice

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