The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Elimination of prions by branched polyamines and implications for therapeutics
Open accessAbstract
We report that branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine, are able to purge PrP Sc , the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture. The removal of PrP Sc by these compounds depends on both the concentration of branched polymer and the duration of exposure. Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1 wk reduced PrP Sc to an undetectable level, a condition that persisted at least 3 wk after removal of the compound. Structure–activity analysis revealed that a high surface density of primary amino groups is required for polyamines to eliminate PrP Sc effectively from cells. The removal of PrP Sc by branched polyamines is attenuated by chloroquine in living cells, and exposure of scrapie-infected brain extracts with branched polyamines at acidic pH rendered the PrP Sc susceptible to protease in vitro , suggesting that endosomes or lysozomes may be the site of action. Our studies suggest that branched polyamines might be useful therapeutic agents for treatment of prion diseases and perhaps a variety of other degenerative disorders.
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Cites
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Metadata
- Authors
- Supattapone, S., Nguyen, H.-O. B., Cohen, F. E., Prusiner, S. B., & Scott, M. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-12-07
- Volume
- 96
- Issue
- 25
- Pages
- 14529-14534
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989838784
- Cited by
- 259
- References
- 49
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Supattapone, S., Nguyen, H.-O. B., Cohen, F. E., Prusiner, S. B., & Scott, M. R. (1999). Elimination of prions by branched polyamines and implications for therapeutics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.25.14529
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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