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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Spillantini, Maria Grazia, Crowther, R. Anthony, Jakes, Ross, Hasegawa, Masato, Goedert, Michel·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.11.6469
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Abstract

Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson’s disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino-terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full-length or close to full-length α-synuclein. The number of α-synuclein-stained structures exceeded that immunoreactive for ubiquitin, which is currently the most sensitive marker of Lewy bodies and Lewy neurites. Staining for α-synuclein thus will replace staining for ubiquitin as the preferred method for detecting Lewy bodies and Lewy neurites. We have isolated Lewy body filaments by a method used for the extraction of paired helical filaments from Alzheimer’s disease brain. By immunoelectron microscopy, extracted filaments were labeled strongly by anti-α-synuclein antibodies. The morphologies of the 5- to 10-nm filaments and their staining characteristics suggest that extended α-synuclein molecules run parallel to the filament axis and that the filaments are polar structures. These findings indicate that α-synuclein forms the major filamentous component of Lewy bodies and Lewy neurites.

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Crossref · 10.1073/pnas.95.11.6469

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2 of 2 references verified0 citation errors · 0 not checkable

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  • SNCA is a major component of Lewy bodies in sporadic Parkinson's disease and dementia with Lewy bodies and of glial and neuronal inclusions in multiple system atrophy.

    “Moreover, SNCA is a major component of neuronal cytoplasmic deposits known as Lewy bodies (LB) in sporadic PD and dementia with Lewy bodies (DLB) and other proteinaceous inclusions in both glial and neuronal cells in multiple system atrophy (MSA) [7].”

    From RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts (2023) · cites this paper as [7]

Citations

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Research works printed but not linked: 34

  1. F H Lewy Handbuch der Neurologie 3 , 920–933 (1912).
  2. M C Trétiakoff Ph.D. thesis (University of Paris, 1919).
  3. 10.1097/00005072-199603000-00001 · DOI
  4. 10.1097/00005072-196507000-00003 · DOI
  5. 10.1002/path.1710990106 · DOI
  6. 10.1097/00005072-196104000-00007 · DOI
  7. 10.1007/BF00685366 · DOI
  8. 10.1111/j.1750-3639.1998.tb00156.x · DOI
  9. 10.1212/WNL.41.9.1402 · DOI
  10. 10.1126/science.6308771 · DOI
  11. M L Schmidt, J Murray, V M-Y Lee, W D Hill, A Wertkin, J Q Trojanowski Am J Pathol 139, 53–65 (1991).
  12. 10.1097/00005072-199305000-00001 · DOI
  13. 10.1007/BF00687787 · DOI
  14. 10.1002/path.1711550105 · DOI · Paper page
  15. 10.1073/pnas.85.12.4501 · DOI
  16. 10.1038/ng0298-106 · DOI · Paper page
  17. 10.1038/42166 · DOI · Paper page
  18. 10.1016/0014-5793(94)00395-5 · DOI
  19. H Ji, J E Liu, T Jia, M Wang, J Liu, G Xiao, B K Joseph, C Rosen, Y E Shi Cancer Res 57, 759–764 (1997).
  20. 10.1073/pnas.85.8.2854 · DOI
  21. 10.1073/pnas.87.10.3947 · DOI
  22. 10.1073/pnas.87.15.5827 · DOI
  23. 10.1016/0896-6273(92)90117-V · DOI
  24. 10.1073/pnas.88.6.2288 · DOI
  25. 10.1016/S0304-3940(97)00891-4 · DOI
  26. A Takeda, M Mallory, M Sundsmo, W Honer, L Hansen, E Masliah Am J Pathol 152, 367–372 (1998).
  27. 10.1007/BF00688674 · DOI
  28. 10.1093/brain/110.5.1131 · DOI
  29. P G Galloway, P Mulvihill, G Perry Am J Pathol 140, 809–822 (1992).
  30. T Iwatsubo, H Yamaguchi, M Fujimoro, H Yokosawa, Y Ihara, J Q Trojanowski, V M-Y Lee Am J Pathol 148, 1517–1529 (1996).
  31. 10.1021/bi961799n · DOI
  32. 10.1002/j.1460-2075.1985.tb04132.x · DOI
  33. 10.1006/jmbi.1996.0322 · DOI
  34. 10.1016/0896-6273(89)90210-9 · DOI · Paper page

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Metadata

Authors
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M.
Affiliations
Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom; and Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1998-05-26
Volume
95
Issue
11
Pages
6469-6473
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.95.11.6469
Cited by
2,868
References
2
Language
en

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