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The small GTPase RalA targets filamin to induce filopodia
Open accessAbstract
The Ras-related small GTPases Rac, Rho, Cdc42, and RalA bind filamin, an actin filament-crosslinking protein that also links membrane and other intracellular proteins to actin. Of these GTPases only RalA binds filamin in a GTP-specific manner, and GTP-RalA elicits actin-rich filopods on surfaces of Swiss 3T3 cells and recruits filamin into the filopodial cytoskeleton. Either a dominant negative RalA construct or the RalA-binding domain of filamin 1 specifically block Cdc42-induced filopod formation, but a Cdc42 inhibitor does not impair RalA’s effects, which, unlike Cdc42, are Rac independent. RalA does not generate filopodia in filamin-deficient human melanoma cells, whereas transfection of filamin 1 restores the functional response. RalA therefore is a downstream intermediate in Cdc42-mediated filopod production and uses filamin in this pathway.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cited by
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Filamins as integrators of cell mechanics and signalling
Stossel, T. P., Condeelis, J., Cooley, L., Hartwig, J. H., Noegel, A., Schleicher, M., & Shapiro, S. S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052082 · Cited by 1,020
Self-citationTakenawa, T., & Miki, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1801 · Cited by 604
The exocyst is a Ral effector complex
Moskalenko, S., Henry, D. O., Rosse, C., Mirey, G., Camonis, J. H., & White, M. A. (2002) · Nature Cell Biology · doi:10.1038/ncb728 · Cited by 423
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelett, C. C., Yeaman, C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1990 · Cited by 402
Metadata
- Authors
- Ohta, Y., Suzuki, N., Nakamura, S., Hartwig, J. H., & Stossel, T. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-02
- Volume
- 96
- Issue
- 5
- Pages
- 2122-2128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2131291909
- Cited by
- 453
- References
- 1
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Ohta, Y., Suzuki, N., Nakamura, S., Hartwig, J. H., & Stossel, T. P. (1999). The small GTPase RalA targets filamin to induce filopodia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.5.2122
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