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Rho and Rac Take Center Stage

Burridge, Keith, Wennerberg, Krister·2004·Cell
DOI 10.1016/s0092-8674(04)00003-0
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Abstract

Many features of cell behavior are regulated by Rho family GTPases, but the most profound effects of these proteins are on the actin cytoskeleton and it was these that first drew attention to this family of signaling proteins. Focusing on Rho and Rac, we will discuss how their effectors regulate the actin cytoskeleton. We will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins. Additionally, we will discuss how there is signaling crosstalk between family members and how various bacterial pathogens have developed strategies to manipulate Rho protein activity so as to enhance their own survival.

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Metadata

Authors
Burridge, K., & Wennerberg, K.
Venue
Cell
Publisher
Elsevier BV
Published
2004-01
Volume
116
Issue
2
Pages
167-179
ISSN
0092-8674
DOI
10.1016/s0092-8674(04)00003-0
Cited by
1,578
References
5
Language
en
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Burridge, K., & Wennerberg, K. (2004). Rho and Rac Take Center Stage. Cell. https://doi.org/10.1016/s0092-8674(04)00003-0