The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Ca2+-induced inhibition of the cardiac Ca2+channel depends on calmodulin
Open accessAbstract
Ca 2+-induced inhibition of α 1C voltage-gated Ca 2+channels is a physiologically important regulatory mechanism that shortens the mean open time of these otherwise long-lasting high-voltage-activated channels. The mechanism of action of Ca 2+has been a matter of some controversy, as previous studies have proposed the involvement of a putative Ca 2+-binding EF hand in the C terminus of α 1C and/or a sequence downstream from this EF-hand motif containing a putative calmodulin (CaM)-binding IQ motif. Previously, using site directed mutagenesis, we have shown that disruption of the EF-hand motif does not remove Ca 2+inhibition. We now show that the IQ motif binds CaM and that disruption of this binding activity prevents Ca 2+inhibition. We propose that Ca 2+entering through the voltage-gated pore binds to CaM and that the Ca/CaM complex is the mediator of Ca 2+inhibition.
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Cites
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Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels
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Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Voltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
Emerging issues of connexin channels: biophysics fills the gap
L. Harris, A. (2001) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583501003705 · Cited by 800
Calcium Fluxes Involved in Control of Cardiac Myocyte Contraction
Bers, D. M. (2000) · Circulation Research · doi:10.1161/01.res.87.4.275 · Cited by 580
Erickson, M. G., Alseikhan, B. A., Peterson, B. Z., & Yue, D. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00438-x · Cited by 465
Metadata
- Authors
- Qin, N., Olcese, R., Bransby, M., Lin, T., & Birnbaumer, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-02
- Volume
- 96
- Issue
- 5
- Pages
- 2435-2438
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2055098453
- Cited by
- 279
- References
- 14
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Qin, N., Olcese, R., Bransby, M., Lin, T., & Birnbaumer, L. (1999). Ca2+-induced inhibition of the cardiac Ca2+channel depends on calmodulin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.5.2435
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
