The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels
Abstract
Intracellular calcium (Ca 2+ ) inhibits the opening of L-type (α 1C ) Ca 2+ channels, providing physiological control of Ca 2+ entry into a wide variety of cells. A structural determinant of this Ca 2+ -sensitive inactivation was revealed by chimeric Ca 2+ channels derived from parental α 1C and α 1E channels, the latter of which is a neuronal channel lacking Ca 2+ inactivation. A consensus Ca 2+ -binding motif (an EF hand), located on the α 1C subunit, was required for Ca 2+ inactivation. Donation of the α 1C EF-hand region to the α 1E channel conferred the Ca 2+ -inactivating phenotype. These results strongly suggest that Ca 2+ binding to the α 1C subunit initiates Ca 2+ inactivation.
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Self-citationCalcium Entry Leads to Inactivation of Calcium Channel in Paramecium
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L-Type Calcium Channels: The Low Down
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Metadata
- Authors
- de Leon, M., Wang, Y., Jones, L., Perez-Reyes, E., Wei, X., Soong, T. W., Snutch, T. P., & Yue, D. T.
- Venue
- Science
- Published
- 1995-12
- Volume
- 270
- Issue
- 5241
- Pages
- 1502-1506
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003784210
- Cited by
- 280
- References
- 35
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels. https://app.cochat.ai/papers/10.1126/science.270.5241.1502
- The paper
- de Leon, M., Wang, Y., Jones, L., Perez-Reyes, E., Wei, X., Soong, T. W., Snutch, T. P., & Yue, D. T. (1995). Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels. Science. https://doi.org/10.1126/science.270.5241.1502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
