The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
Open accessAbstract
Human fibroblasts whose lifespan in culture has been extended by expression of a viral oncogene eventually undergo a growth crisis marked by failure to proliferate. It has been proposed that telomere shortening in these cells is the property that limits their proliferation. Here we report that ectopic expression of the wild-type reverse transcriptase protein (hTERT) of human telomerase averts crisis, at the same time reducing the frequency of dicentric and abnormal chromosomes. Surprisingly, as the resulting immortalized cells containing active telomerase continue to proliferate, their telomeres continue to shorten to mean lengths below those in control cells that enter crisis. These results provide evidence for a protective function of human telomerase that allows cell proliferation without requiring net lengthening of telomeres.
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Cites
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Cited by
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,107
Self-citationTelomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,377
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Rules for Making Human Tumor Cells
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Metadata
- Authors
- Zhu, J., Wang, H., Bishop, J. M., & Blackburn, E. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-30
- Volume
- 96
- Issue
- 7
- Pages
- 3723-3728
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967017947
- Cited by
- 381
- References
- 42
- FWCI
- 21.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhu, J., Wang, H., Bishop, J. M., & Blackburn, E. H. (1999). Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.7.3723
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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