Rules for Making Human Tumor Cells

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The serial cultivation of human diploid cell strains

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Caspases: Enemies Within

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Genetic Alterations during Colorectal-Tumor Development

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Lessons from hereditary colorectal cancer

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Cellular survival: a play in three Akts

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Genetic instabilities in human cancers

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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

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Creation of human tumour cells with defined genetic elements

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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

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The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

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The age distribution of cancer and a multi-stage theory of carcinogenesis

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Diversity of gene expression in adenocarcinoma of the lung

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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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The role of angiogenesis in tumor growth.

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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The Multiple Roles of PTEN in Tumor Suppression

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Ten years of protein kinase B signalling: a hard Akt to follow

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Two genetic hits (more or less) to cancer

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The INK4a/ARF network in tumour suppression

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The age of cancer

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Modelling the molecular circuitry of cancer

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

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Regulation of protein kinase cascades by protein phosphatase 2A

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Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

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Understanding Ras: ‘it ain’t over ’til it’s over’

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A role for both RB and p53 in the regulation of human cellular senescence*1

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Cooperation between oncogenes

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Genetic instability and darwinian selection in tumours

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Bcl-2 Gene Family and the Regulation of Programmed Cell DeathPreprint

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Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

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Dissociation among <i>in vitro</i> telomerase activity, telomere maintenance, and cellular immortalization

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Viral oncogenes

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Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

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Functions of the MDM2 oncoprotein

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Oncoprotein Networks

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The INK4A/ARF locus and its two gene products.

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Telomerase and cancer

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Tumor Suppressor Genes: The Puzzle and the Promise

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THE ROLE OF DNA METHYLATION IN CANCER GENETICS AND EPIGENETICS

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

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Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

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Telomerase, Cell Immortality, and Cancer

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Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

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COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

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Cell-cycle control and its watchman

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Molecular classification of multiple tumor types

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Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

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Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

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Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis

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Signalling networks that cause cancer

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Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

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Establishing a Link between Oncogenes and Tumor Angiogenesis

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The importance of being K-Ras

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Telomerase activation, cellular immortalization and cancer

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A genetically tractable model of human glioma formation.

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Resistance of human cells to tumorigenesis induced by cloned transforming genes.

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Critical Role for SV40 Small-t Antigen in Human Cell Transformation

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The role of human papillomaviruses in human cancers

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The role of the SV40 ST antigen in cell growth promotion and transformation

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HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.

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Activation of p53 by oncogenes.

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The Expanding Role of Cell Cycle Regulators

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Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

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p14ARF nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways

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