The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pathways of As(III) detoxification in Saccharomyces cerevisiae
Open accessAbstract
Saccharomyces cerevisiae has two independent transport systems for the removal of arsenite from the cytosol. Acr3p is a plasma membrane transporter that confers resistance to arsenite, presumably by arsenite extrusion from the cells. Ycf1p, a member of the ABC transporter superfamily, catalyzes the ATP-driven uptake of As(III) into the vacuole, also producing resistance to arsenite. Vacuolar accumulation requires a reductant such as glutathione, suggesting that the substrate is the glutathione conjugate, As(GS) 3 . Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity. Thus, Acr3p and Ycf1p represent separate pathways for the detoxification of arsenite in yeast.
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Cites
Klionsky, D. J., & Emr, S. D. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08348.x · Cited by 325
Cited by
Zhao, F.-J., McGrath, S. P., & Meharg, A. A. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112152 · Cited by 1,246
Arsenic uptake and metabolism in arsenic resistant and nonresistant plant species
Meharg, A. A., & Hartley‐Whitaker, J. (2002) · New Phytologist · doi:10.1046/j.1469-8137.2002.00363.x · Cited by 1,200
Arsenic uptake and metabolism in plants
Zhao, F. J., Ma, J. F., Meharg, A. A., & McGrath, S. P. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02716.x · Cited by 1,185
Biochemistry of arsenic detoxification
Rosen, B. P. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03186-1 · Cited by 783
Self-citationMicrobial arsenic: from geocycles to genes and enzymes
Mukhopadhyay, R., Rosen, B. P., Phung, L. T., & Silver, S. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00617.x · Cited by 726
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Metadata
- Authors
- Ghosh, M., Shen, J., & Rosen, B. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5001-5006
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091297151
- Cited by
- 399
- References
- 1
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Ghosh, M., Shen, J., & Rosen, B. P. (1999). Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.5001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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