The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate
Open accessAbstract
The pharmacological action of salicylate cannot be explained by its inhibition of cyclooxygenase (COX) activity. In this report, the effects of aspirin and sodium salicylate on COX-2 expressions in human umbilical vein endothelial cells and foreskin fibroblasts were evaluated. Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1β and phorbol 12-myristate 13-acetate. The suppressing effect was more pronounced in cultured cells deprived of fetal bovine serum for 24 h, suggesting that it may be cell cycle related. Salicylate inhibited nascent COX-2 transcript synthesis but had no effect on COX-2 mRNA stability. It inhibited COX-2 promoter activity in a concentration-dependent manner. In mice pretreated with aspirin (10 and 30 mg/kg), followed by challenge with lipopolysaccharide, COX-2 mRNA expression in peritoneal macrophages was markedly suppressed. These findings suggest that salicylate exerts its antiinflammatory action in part by suppressing COX-2 induction, thereby reducing the synthesis of proinflammatory prostaglandins.
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Cites
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McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 532
The role of herbs and spices in cancer prevention
Kaefer, C. M., & Milner, J. A. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.11.003 · Cited by 493
Anti-inflammatory effects of aspirin and sodium salicylate
Amann, R., & Peskar, B. A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01828-9 · Cited by 372
Naturally occurring antinociceptive substances from plants
Calixto, J. B., Beirith, A., Ferreira, J., Santos, A. R. S., Filho, V. C., & Yunes, R. A. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200009)14:6<401::aid-ptr762>3.0.co;2-h · Cited by 339
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Aronoff, D. M., & Neilson, E. G. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00834-8 · Cited by 326
Metadata
- Authors
- Xu, X.-M., Sansores-Garcia, L., Chen, X.-M., Matijevic-Aleksic, N., Du, M., & Wu, K. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5292-5297
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117064945
- Cited by
- 301
- References
- 33
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, X.-M., Sansores-Garcia, L., Chen, X.-M., Matijevic-Aleksic, N., Du, M., & Wu, K. K. (1999). Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.5292
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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