The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.
Open accessAbstract
Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.
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“These results are also interesting when considered with findings suggesting that coactivators are critical in mediating sexual differentiation of the brain (14,17).”
From The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior (2010) · cites this paper as [17]
In the citing paper
“masculinization of the male brain may in part be dependent on the effects of androgens on androgen receptors (Auger, Tetel, & McCarthy, 2000;Bakker, Honda, Harada, & Balthazart, 2002;Meaney & McEwen, 1986;Morris, Jordan, Dugger, & Breedlove, 2005).”
From Play fighting in androgen-insensitivetfm rats: Evidence that androgen receptors are necessary for the development of adult playful attack and defense (2006) · cites this paper as Auger, Tetel, & McCarthy, 2000
Citations
Cites
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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S. A., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,398
Evidence for a morphological sex difference within the medial preoptic area of the rat brain
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A two-step mechanism for the interaction of estradiol with rat uterus.
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Xu, J., Qiu, Y., DeMayo, F. J., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1998) · Science · doi:10.1126/science.279.5358.1922 · Cited by 680
Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.
Shibata, H., Spencer, T. E., Oñate, S. A., Jenster, G. W., Tsai, M., Tsai, M., & O’Malley, B. W. (1997) · PubMed · Cited by 520
The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1
Bevan, C. L., Hoare, S., Claessens, F., Heery, D. M., & Parker, M. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8383 · Cited by 424
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Hsiao, P., Lin, D., Nakao, R., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20229 · Cited by 221
Research works printed but not linked: 3
- 10.1002/(SICI)1097-0045(1996)6 <9::AID-PROS3>3.0.CO;2-N · DOI
- H Shibata, T E Spencer, S A Onate, G Jenster, S Y Tsai, M J Tsai, B W O'Malley Recent Prog Horm Res 52, 141–164 (1997).
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Cited by
Sorted by citations
Estrogen Actions Throughout the Brain
McEwen, B. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.357 · Cited by 915
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885
Self-citationReview of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family
Xu, J., & Li, Q. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0116 · Cited by 493
De Vries, G. J., & Panzica, G. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.050 · Cited by 346
Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
Schumacher, M., Guennoun, R., Stein, D. G., & Nicola, A. F. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.001 · Cited by 247
Metadata
- Authors
- Auger, A. P., Tetel, M. J., & McCarthy, M. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-06-20
- Volume
- 97
- Issue
- 13
- Pages
- 7551-7555
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC16583
- OpenAlex
- W2035162632
- Cited by
- 196
- References
- 34
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 5
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH52716)
- National Institute of Mental Health (R29MH052716, MH 52716, R01MH052716)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD08618, F32HD008618)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- SRC-1, nuclear receptor coactivators, sexual differentiation of the brain, brain development, estrogen, defeminization, male reproductive behavior, steroid hormone action, neonatal rat brain
- MeSH terms
- Animals, Brain, Female, Male, Sexual Behavior, Animal, Transcription Factors, Trans-Activators, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Rats, Histone Acetyltransferases, Nuclear Receptor Coactivator 1
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