Cited by 196Sexual Differentiation and DisordersEstrogen and related hormone effectsGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

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Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.

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Auger, Anthony P., Tetel, Marc J., McCarthy, Margaret M.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.97.13.7551PMC PMC16583

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Abstract

Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.

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Authors: Auger, A. P., Tetel, M. J., & McCarthy, M. M.
Affiliations: University of Maryland, Baltimore (US)
ORCID: Auger, Anthony P.
Tetel, Marc J.
McCarthy, Margaret M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-06-20
Volume: 97
Issue: 13
Pages: 7551-7555
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.97.13.7551
PMC: PMC16583
OpenAlex: W2035162632
Cited by: 196
References: 34
Citations by year: 2026: 3 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 5
FWCI: 4.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (MH52716)
National Institute of Mental Health (R29MH052716, MH 52716, R01MH052716)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD08618, F32HD008618)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords: SRC-1, nuclear receptor coactivators, sexual differentiation of the brain, brain development, estrogen, defeminization, male reproductive behavior, steroid hormone action, neonatal rat brain
MeSH terms: Animals, Brain, Female, Male, Sexual Behavior, Animal, Transcription Factors, Trans-Activators, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Rats, Histone Acetyltransferases, Nuclear Receptor Coactivator 1

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Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.

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