The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain
Open accessAbstract
The development of an in vivo procedure for the induction of massive proliferation, directed migration, and neurodifferentiation (PMD) in the damaged adult central nervous system would hold promise for the treatment of human neurodegenerative disorders such as Parkinson's disease. We investigated the in vivo induction of PMD in the forebrain of the adult rat by using a combination of 6-hydroxydopamine lesion of the substantia nigra dopaminergic neurons and infusions of transforming growth factor α (TGFα) into forebrain structures. Only in animals with both lesion and infusion of TGFα was there a rapid proliferation of forebrain stem cells followed by a timed migration of a ridge of neuronal and glial progenitors directed toward the region of the TGFα infusion site. Subsequently, increasing numbers of differentiated neurons were observed in the striatum. In behavioral experiments, there was a significant reduction of apomorphine-induced rotations in animals receiving the TGFα infusions. These results show that the brain contains stem cells capable of PMD in response to an exogenously administered growth factor. This finding has significant implications with respect to the development of treatments for both acute neural trauma and neurodegenerative diseases.
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Cites
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Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S.-M., Finato, N., Bussani, R., Nadal-Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,429
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,047
The Evolving Concept of a Stem Cell
Blau, H. M., Brazelton, T. R., & Weimann, J. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00409-3 · Cited by 1,046
Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases
Lie, D. C., Song, H., Colamarino, S. A., Ming, G.-L., & Gage, F. H. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121631 · Cited by 592
From angiogenesis to neuropathology
Greenberg, D. A., & Jin, K. (2005) · Nature · doi:10.1038/nature04481 · Cited by 532
Metadata
- Authors
- Fallon, J., Reid, S., Kinyamu, R., Opole, I., Opole, R., Baratta, J., Korc, M., Endo, T. L., Duong, A., Nguyen, G., Karkehabadhi, M., Twardzik, D., & Loughlin, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-12-19
- Volume
- 97
- Issue
- 26
- Pages
- 14686-14691
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123285567
- Cited by
- 425
- References
- 39
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Fallon, J., Reid, S., Kinyamu, R., Opole, I., Opole, R., Baratta, J., Korc, M., Endo, T. L., Duong, A., Nguyen, G., Karkehabadhi, M., Twardzik, D., & Loughlin, S. (2000). In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.26.14686
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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