The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases
Abstract
New cells are continuously generated from immature proliferating cells throughout adulthood in many organs, thereby contributing to the integrity of the tissue under physiological conditions and to repair following injury. In contrast, repair mechanisms in the adult central nervous system (CNS) have long been thought to be very limited. However, recent findings have clearly demonstrated that in restricted areas of the mammalian brain, new functional neurons are constantly generated from neural stem cells throughout life. Moreover, stem cells with the potential to give rise to new neurons reside in many different regions of the adult CNS. These findings raise the possibility that endogenous neural stem cells can be mobilized to replace dying neurons in neurodegenerative diseases. Indeed, recent reports have provided evidence that, in some injury models, limited neuronal replacement occurs in the CNS. Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases.
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Cites
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Metadata
- Authors
- Lie, D. C., Song, H., Colamarino, S. A., Ming, G.-L., & Gage, F. H.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2004-02-10
- Volume
- 44
- Issue
- 1
- Pages
- 399-421
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2141568187
- Cited by
- 592
- References
- 160
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lie, D. C., Song, H., Colamarino, S. A., Ming, G.-L., & Gage, F. H. (2004). Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.44.101802.121631
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
