The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Effect of Treatment, during Primary Infection, on Establishment and Clearance of Cellular Reservoirs of HIV-1
Open accessAbstract
Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV-1); this retention is an obstacle to sustained control of infection. To assess the impact that initiating treatment during primary HIV-1 infection has on this cell population, we analyzed the decay kinetics of HIV-1 DNA and of infectivity associated with cells activated ex vivo in 27 patients who initiated therapy before or <6 months after seroconversion and in whom viremia was suppressed to <50 copies/mL. The clearance rates of cellular reservoirs could not be distinguished by these techniques (median half-life, 20 weeks) during the first year of HAART. The clearance of HIV-1 DNA slowed significantly during the subsequent 3 years of treatment (median half-life, 70 weeks), consistent with heterogeneous cellular reservoirs being present. Total cell-associated infectivity (CAI) after 1 year of treatment was undetectable (<0.07 infectious units/million cells [IUPM]) in most patients initiating treatment during primary infection either before (9/9) or <6 months after (6/8) seroconversion. In contrast, all 17 control patients who initiated HAART during chronic infection retained detectable CAI after 3-6 years of treatment (median reservoir size, 1.1 IUPM; P<.0005). These results suggest that treatment <6 months after seroconversion may facilitate long-term control of cellular reservoirs that maintain HIV-1 infection during treatment.
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Cites
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Cited by
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003211 · Cited by 1,011
The Challenge of Finding a Cure for HIV Infection
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HIV rebounds from latently infected cells, rather than from continuing low-level replication
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Metadata
- Authors
- Strain, M. C., Little, S. J., Daar, E. S., Havlir, D. V., Günthard, H. F., Lam, R. Y., Daly, O. A., Nguyen, J., Ignacio, C. C., Spina, C. A., Richman, D. D., & Wong, J. K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05
- Volume
- 191
- Issue
- 9
- Pages
- 1410-1418
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2172042588
- Cited by
- 331
- References
- 52
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Strain, M. C., Little, S. J., Daar, E. S., Havlir, D. V., Günthard, H. F., Lam, R. Y., Daly, O. A., Nguyen, J., Ignacio, C. C., Spina, C. A., Richman, D. D., & Wong, J. K. (2005). Effect of Treatment, during Primary Infection, on Establishment and Clearance of Cellular Reservoirs of HIV-1. The Journal of Infectious Diseases. https://doi.org/10.1086/428777
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
