The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
Open accessAbstract
Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. The present study indicates that estrogen is neuroprotective against N -methyl- d -aspartate (NMDA)- and kainate-mediated neurotoxicity, an effect mediated by tyrosine kinase/mitogen-activated protein kinase (MAPK) pathways. Estrogen also stimulates tyrosine phosphorylation of NMDA receptors via an src tyrosine kinase/MAPK pathway. Finally, estrogen-mediated enhancement of long-term potentiation in hippocampal slices is mediated by activation of an src tyrosine kinase pathway. Thus, estrogen, by activating an src tyrosine kinase and the extracellular signal-related protein kinase/MAPK signaling pathway, both enhances NMDA receptor function and long-term potentiation and retains neuroprotective properties against excitotoxicity. These findings warrant further evaluation of the usefulness of estrogenic compounds for the treatment of Alzheimer's disease and other neurodegenerative diseases.
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Cited by
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Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
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Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women
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Metadata
- Authors
- Bi, R., Broutman, G., Foy, M. R., Thompson, R. F., & Baudry, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-21
- Volume
- 97
- Issue
- 7
- Pages
- 3602-3607
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048947179
- Cited by
- 279
- References
- 38
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bi, R., Broutman, G., Foy, M. R., Thompson, R. F., & Baudry, M. (2000). The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.7.3602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
