The MAPK cascade is required for mammalian associative learning

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works

The MAPK signaling cascade

Seger, R., & Krebs, E. G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.9.7601337 · Cited by 3,631 · see citing works

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016 · see citing works

Modality-Specific Retrograde Amnesia of Fear

Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works

cPLA2 is phosphorylated and activated by MAP kinase

Lin, L., Wartmann, M., Lin, A. Y., Knopf, J. L., Seth, A., & Davis, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)90666-e · Cited by 1,851 · see citing works

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472 · see citing works

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,351 · see citing works

Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats

Ranck, J. B. (1973) · Experimental Neurology · doi:10.1016/0014-4886(73)90290-2 · Cited by 1,322 · see citing works

Fear conditioning induces associative long-term potentiation in the amygdala

Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works

Cognitive Neuroscience and the Study of Memory

Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,300 · see citing works

Regulation of transcription by MAP kinase cascades

Treisman, R. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80067-6 · Cited by 1,296 · see citing works

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

Xing, J. W., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,246 · see citing works

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works

Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation

Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049 · see citing works

Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037 · see citing works

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

English, J. D., & Sweatt, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19103 · Cited by 860 · see citing works

Fear conditioning induces a lasting potentiation of synaptic currents in vitro

McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works

Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear.

Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.1093 · Cited by 615 · see citing works

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

English, J. D., & Sweatt, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24329 · Cited by 579 · see citing works

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545 · see citing works

A role for the Ras signalling pathway in synaptic transmission and long-term memory

Brambilla, R., Gnesutta, N., Minichiello, L., White, G., Roylance, A. J., Herron, C. E., Ramsey, M., Wolfer, D. P., Cestari, V., Rossi‐Arnaud, C., et al. (1997) · Nature · doi:10.1038/36849 · Cited by 471 · see citing works

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

Jovanovic, J. N., Benfenati, F., Siow, Y. L., Sihra, T. S., Sanghera, J. S., Pelech, S., Greengard, P., & Czernik, A. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3679 · Cited by 393 · see citing works

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of <i>Acra7</i>-Deficient Mice

Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A. (1998) · Learning &amp; Memory · doi:10.1101/lm.5.4.302 · Cited by 298 · see citing works

N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.

Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 295 · see citing works

Correlation between the Pharmacology of Long-Term Potentiation and the Pharmacology of Memory

Izquierdo, I., & Medina, J. H. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.1002 · Cited by 230 · see citing works

A signal chain of events

Roberts, T. M. (1992) · Nature · doi:10.1038/360534a0 · Cited by 211 · see citing works

Inhibition of calcium/calmodulin-dependent protein kinase in drosophila disrupts behavioral plasticity

Griffith, L. C., Verselis, L. M., Aitken, K. M., Kyriacou, C. P., Danho, W., & Greenspan, R. J. (1993) · Neuron · doi:10.1016/0896-6273(93)90337-q · Cited by 204 · see citing works

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

Brugg, B., & Matus, A. I. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.4.735 · Cited by 199 · see citing works

A Million Dollar Question: Does LTP = Memory?

Stevens, C. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80426-2 · Cited by 180 · see citing works

Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.

Thiel, G., Czernik, A. J., Gorelick, F. S., Nairn, A. C., & Greengard, P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6337 · Cited by 176 · see citing works

Transient Activation of Cyclic AMP-dependent Protein Kinase during Hippocampal Long-term Potentiation

Roberson, E. D., & Sweatt, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30436 · Cited by 160 · see citing works

p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

Fiore, R. S., Bayer, V. E., Pelech, S., Posada, J. A., Cooper, J. A., & Baraban, J. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90516-i · Cited by 158 · see citing works

Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia

Michael, D., Martin, K. C., Seger, R., Ning, M., Baston, R., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1864 · Cited by 141 · see citing works

Induction of a Specific Olfactory Memory Leads to a Long-Lasting Activation of Protein Kinase C in the Antennal Lobe of the Honeybee

Grünbaum, L., & Müller, U. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04384.1998 · Cited by 124 · see citing works

A biochemist's view of long-term potentiation.Preprint

Roberson, E. D., English, J. D., & Sweatt, J. D. (1996) · Learning & Memory · doi:10.1101/lm.3.1.1 · Cited by 118 · see citing works

Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK801

Hargreaves, E. L., & Cain, D. P. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80249-9 · Cited by 105 · see citing works

Mammalian MAP kinase modules: how to transduce specific signals.

Brunet, A., & Pouysségur, J. (1997) · PubMed · Cited by 104 · see citing works

Phosphorylation of Mitogen-Activated Protein Kinase by One-Trial and Multi-Trial Classical Conditioning

Crow, T., Xue‐Bian, J., Siddiqi, V., Kang, Y., & Neary, J. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03480.1998 · Cited by 84 · see citing works

Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat

Wolfman, C., Fin, C. A., Dias, M., Bianchin, M. M., da Silva, R. C., Schmitz, P. K., Medina, J. H., & Izquierdo, I. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80001-9 · Cited by 79 · see citing works

Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats

Jerusalinsky, D. A., Quillfeldt, J. A., Walz, R., et al. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80063-9 · Cited by 71 · see citing works

Rat gustatory memory requires protein kinase C activity in the amygdala and cortical gustatory area

Yasoshima, Y., & Yamamoto, T. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00009 · Cited by 60 · see citing works

Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation

Sweatt, J. D., Atkins, C. M., Johnson, J. E., English, J., Roberson, E. D., Chen, S., Newton, A. C., & Klann, E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71031075.x · Cited by 57 · see citing works

Spatial learning alters hippocampal calcium/calmodulin-dependent protein kinase II activity in rats

Tan, S.-E., & Liang, K. (1996) · Brain Research · doi:10.1016/0006-8993(95)01411-x · Cited by 56 · see citing works

Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning

Bordi, F., Marcon, C., Chiamulera, C., & Reggiani, A. M. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00101-3 · Cited by 52 · see citing works

Investigations on the role of hippocampal protein kinase C on memory processes: pharmacological approach

Noguès, X., Jaffard, R., & Micheau, J. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00194-5 · Cited by 28 · see citing works

Inhibitory avoidance learning alters the amygdala calcium/calmodulin-dependent protein kinase II activity in rats

Tan, S.-E., & Liang, K. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01298-x · Cited by 27 · see citing works

Emotion circuits in the brain

LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works

The Emotional Brain, Fear, and the Amygdala

LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works

MAPK cascade signalling and synaptic plasticity

Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454 · see citing works

ERK signalling: A master regulator of cell behaviour, life and fate

Lavoie, H., Gagnon, J., & Therrien, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0255-7 · Cited by 1,185 · see citing works

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

Sweatt, J. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00054.x · Cited by 1,131 · see citing works

Regulation of histone acetylation during memory formation in the hippocampus

Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131 · see citing works

Signal-Processing Machines at the Postsynaptic Density

Kennedy, M. B. (2000) · Science · doi:10.1126/science.290.5492.750 · Cited by 788 · see citing works

Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of<i>Arc</i>Synthesis

Ying, S.-W., Futter, M., Rosenblum, K., Webber, M. J., Hunt, S. P., Bliss, T. V. P., & Bramham, C. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01532.2002 · Cited by 784 · see citing works

Epigenetic mechanisms in memory formation

Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767 · see citing works

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.-C., Stipanovich, A., Caboche, J., Lombroso, P. J., Nairn, A. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408305102 · Cited by 614 · see citing works

Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works

Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective

Schafe, G. E., Nader, K., Blair, H. T., & LeDoux, J. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01969-x · Cited by 510 · see citing works

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:<i>In Vitro</i>and<i>In Vivo</i>Mechanisms Related to Alzheimer's Disease

Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H., & Sweatt, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04125.2001 · Cited by 462 · see citing works

Epigenetic mechanisms in cognition

Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works

Molecular mechanisms underlying emotional learning and memory in the lateral amygdala

Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

Wong, S. T., Athos, J., Figueroa, X. A., Pineda, V. V., Schaefer, M. L., Chavkin, C. C., Muglia, L. J., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(01)80036-2 · Cited by 486 · see citing works

Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465 · see citing works

Fear memory

Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453 · see citing works

Neural and cellular mechanisms of fear and extinction memory formation

Orsini, C. A., & Maren, S. (2012) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works

Different Neuronal Activity Patterns Induce Different Gene Expression Programs

Tyssowski, K. M., DeStefino, N. R., Cho, J.-H., Dunn, C. J., Poston, R. G., Carty, C. E., Jones, R. D., Chang, S. M., Romeo, P., Wurzelmann, M. K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.001 · Cited by 390 · see citing works

Is Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory

Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382 · see citing works

Neuroplasticity Mediated by Altered Gene Expression

McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999) · Learning &amp; Memory · doi:10.1101/lm.6.5.478 · Cited by 341 · see citing works

BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation.

Alonso, M., Vianna, M. R. M., Depino, A. M., Mello e Souza, T., Pereira, P., Szapiro, G., Viola, H., Pitossi, F., Izquierdo, I., & Medina, J. H. (2002) · Hippocampus · doi:10.1002/hipo.10035 · Cited by 339 · see citing works

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

Chin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312 · see citing works

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works

HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration

Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262 · see citing works

The impact of sugar consumption on stress driven, emotional and addictive behaviors

Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works

β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

Tong, L., Balazs, R., Thornton, P. L., & Cotman, C. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5463-03.2004 · Cited by 221 · see citing works

Accelerated Plaque Accumulation, Associative Learning Deficits, and Up-regulation of α7 Nicotinic Receptor Protein in Transgenic Mice Co-expressing Mutant Human Presenilin 1 and Amyloid Precursor Proteins

Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200164200 · Cited by 212 · see citing works

Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

Guan, Z., Peng, X., & Fang, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.032 · Cited by 208 · see citing works

Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here?

Frick, K. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.08.015 · Cited by 205 · see citing works

Protein Synthesis Is Required for the Enhancement of Long-Term Potentiation and Long-Term Memory by Spaced Training

Scharf, M. T., Woo, N. H., Lattal, K. M., Young, J. Z., Nguyen, P. V., & Abel, T. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.2770 · Cited by 204 · see citing works

Loss of α7 Nicotinic Receptors Enhances β-Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

Hernandez, C. M., Kayed, R., Zheng, H., Sweatt, J. D., & Dineley, K. T. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5038-09.2010 · Cited by 204 · see citing works

Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons

Cavanaugh, J. E., Ham, J., Hetman, M., Poser, S., Yan, C., & Xia, Z. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00434.2001 · Cited by 196 · see citing works

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning &amp; Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works

Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory

Sun, W., Liu, Z., Jiang, X., Chen, M. B., Dong, H., Liu, J., Südhof, T. C., & Quake, S. R. (2024) · Nature · doi:10.1038/s41586-023-07011-6 · Cited by 165 · see citing works

Selective early-acquired fear memories undergo temporary suppression during adolescence

Pattwell, S. S., Bath, K. G., Casey, B. J., Ninan, I., & Lee, F. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012975108 · Cited by 161 · see citing works

The Role of Extracellular Regulated Kinases I/II in Late-Phase Long-Term Potentiation

Rosenblum, K., Futter, M., Voss, K., Erent, M., Skehel, P. A., French, P., Obosi, L., Jones, M. W., & Bliss, T. V. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05432.2002 · Cited by 155 · see citing works

ERK2 Contributes to the Control of Social Behaviors in Mice

Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145 · see citing works

Regulation of chromatin structure in memory formation

Roth, T. L., & Sweatt, J. D. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.011 · Cited by 138 · see citing works

Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear

Tronson, N. C., Schrick, C., Guzman, Y. F., Huh, K. H., Srivastava, D. P., Penzes, P., Guedea, A. L., Gao, C., & Radulovic, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5619-08.2009 · Cited by 136 · see citing works

Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory

Li, L., Yun, S. H., Keblesh, J., Trommer, B. L., Xiong, H., Radulovic, J., & Tourtellotte, W. G. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.004 · Cited by 124 · see citing works

Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in<i>Aplysia</i>

Sharma, S. K., Sherff, C. M., Shobe, J., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03899.2003 · Cited by 125 · see citing works

αCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory

Irvine, E. E., Vernon, J., & Giese, K. P. (2005) · Nature Neuroscience · doi:10.1038/nn1431 · Cited by 119 · see citing works

How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets

Peixoto, L., Risso, D., Poplawski, S. G., Wimmer, M. E., Speed, T. P., Wood, M. A., & Abel, T. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv736 · Cited by 105 · see citing works

Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: Role of ERK kinase 1 (MEK1)

Dwivedi, Y., Rizavi, H. S., Zhang, H., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990575 · Cited by 101 · see citing works

Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade

Cesarini, L., Alfieri, P., Pantaleoni, F., Vasta, I., Cerutti, M., Petrangeli, V., Mariotti, P., Leoni, C., Ricci, D., Vicari, S., et al. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32488 · Cited by 98 · see citing works

ERK1/2 Antagonizes Glycogen Synthase Kinase-3β-induced Apoptosis in Cortical Neurons

Hetman, M., Hsuan, S.-L., Habas, A., Higgins, M. J., & Xia, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111227200 · Cited by 88 · see citing works

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86 · see citing works

Epigenetic dynamics in psychiatric disorders: Environmental programming of neurodevelopmental processes

Kofink, D., Boks, M. P. M., Timmers, H. T. M., & Kas, M. J. (2013) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.020 · Cited by 83 · see citing works

MAPK Establishes a Molecular Context That Defines Effective Training Patterns for Long-Term Memory Formation

Philips, G. T., Ye, X., Kopec, A. M., & Carew, T. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5561-12.2013 · Cited by 70 · see citing works

Stress, epigenetic control of gene expression and memory formation

Trollope, A. F., Gutièrrez-Mecinas, M., Mifsud, K. R., Collins, A., Saunderson, E. A., & Reul, J. M. H. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.03.022 · Cited by 69 · see citing works

A role for ERKII in synaptic pattern selectivity on the time‐scale of minutes

Ajay, S. M., & Bhalla, U. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03725.x · Cited by 64 · see citing works

Epigenetic Mechanisms of Rubinstein–Taybi Syndrome

Park, E., Kim, Y., Ryu, H., Kowall, N. W., Lee, J., & Ryu, H. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8285-3 · Cited by 63 · see citing works

D-Cycloserine Facilitates Extinction the First Time but not the Second Time: An Examination of the Role of NMDA Across the Course of Repeated Extinction Sessions

Langton, J. M., & Richardson, R. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.32 · Cited by 63 · see citing works

Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61 · see citing works

Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice

Yufune, S., Satoh, Y., Takamatsu, I., Ohta, H., Kobayashi, Y., Takaenoki, Y., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2015) · Scientific Reports · doi:10.1038/srep10252 · Cited by 57 · see citing works

Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation

Miller, C. A., & Sweatt, J. D. (2006) · Learning &amp; Memory · doi:10.1101/lm.304606 · Cited by 53 · see citing works

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Burns, A. M., Farinelli-Scharly, M., Hugues-Ascery, S., Sanchez-Mut, J. V., Santoni, G., & Gräff, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116797119 · Cited by 49 · see citing works

Genetic Targeting of ERK1 Suggests a Predominant Role for ERK2 in Murine Pain Models

Alter, B. J., Zhao, C., Karim, F., Landreth, G. E., & Gereau, R. W. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6103-09.2010 · Cited by 47 · see citing works

Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system

Otsubo, Y., Satoh, Y., Kodama, M., Araki, Y., Satomoto, M., Sakamoto, E., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2012) · Pain · doi:10.1016/j.pain.2012.07.020 · Cited by 33 · see citing works

Activation pattern of the limbic system following spatial learning under stress

Kogan, I., & Richter‐Levin, G. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06034.x · Cited by 34 · see citing works

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Philips, G. T., Kopec, A. M., & Carew, T. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.05.003 · Cited by 33 · see citing works

Extracellular signal–regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model

Tsai, Y.-T., Wang, C.-C., Leung, P.-O., Lin, K.-C., Chio, C.-C., Hu, C.-Y., & Kuo, J.-R. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.02.009 · Cited by 25 · see citing works

ERK signaling is required for eye-specific retino-geniculate segregation

Naska, S., Cenni, M. C., Menna, E., & Maffei, L. (2004) · Development · doi:10.1242/dev.01212 · Cited by 14 · see citing works

Differential Inhibition of E-S Potentiation and Long-term Potentiation by Cell-Derived and Arctic Amyloid Beta

Orr, A., Clark, J. K., & Madison, D. V. (2020) · Alzheimers Disease & Dementia · doi:10.36959/734/378

Differential Inhibition of E-S Potentiation and Long-term Potentiation by Cell-derived and Arctic Amyloid BetaPreprint

Orr, A., Clark, J. K., & Madison, D. V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/601492

Effects of lead on long-term potentiation in hippocampal CA3 vary with age

Hussain, R. J., Parsons, P. J., & Carpenter, D. O. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00051-1 · Cited by 17 · see citing works

Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdalaPreprint

Maddox, S. A., Monsey, M. S., & Schafe, G. E. (2010) · Learning & Memory · doi:10.1101/lm.1980211 · Cited by 99 · see citing works

Opposite effects of lateral septal LTP and lateral septal lesions on contextual fear conditioning in mice.

Vouimba, R. M., Garcia, R., & Jaffard, R. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.4.875 · Cited by 37 · see citing works