The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice
Open accessAbstract
Type XV collagen occurs widely in the basement membrane zones of tissues, but its function is unknown. To understand the biological role of this protein, a null mutation in the Col15a1 gene was introduced into the germ line of mice. Despite the complete lack of type XV collagen, the mutant mice developed and reproduced normally, and they were indistinguishable from their wild-type littermates. However, Col15a1 -deficient mice showed progressive histological changes characteristic for muscular diseases after 3 months of age, and they were more vulnerable than controls to exercise-induced muscle injury. Despite the antiangiogenic role of type XV collagen-derived endostatin, the development of the vasculature appeared normal in the null mice. Nevertheless, ultrastructural analyses revealed collapsed capillaries and endothelial cell degeneration in the heart and skeletal muscle. Furthermore, perfused hearts showed a diminished inotropic response, and exercise resulted in cardiac injury, changes that mimic early or mild heart disease. Thus, type XV collagen appears to function as a structural component needed to stabilize skeletal muscle cells and microvessels.
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Cites
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Cited by
Basement membranes: structure, assembly and role in tumour angiogenesis
Kalluri, R. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1094 · Cited by 1,748
Large-scale analysis of the human and mouse transcriptomes
Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012025199 · Cited by 1,466
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,451
Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J. C., Maeshima, Y., Yang, C., Hynes, R. O., Werb, Z., Sudhakar, A., & Kalluri, R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00133-8 · Cited by 559
Endogenous Inhibitors of Angiogenesis
Nyberg, P., Xie, L., & Kalluri, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2427 · Cited by 553
Metadata
- Authors
- Eklund, L., Piuhola, J., Komulainen, J., Sormunen, R., Ongvarrasopone, C., Fässler, R., Muona, A., Ilves, M., Ruskoaho, H., Takala, T. E. S., & Pihlajaniemi, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-23
- Volume
- 98
- Issue
- 3
- Pages
- 1194-1199
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2139562032
- Cited by
- 226
- References
- 1
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Eklund, L., Piuhola, J., Komulainen, J., Sormunen, R., Ongvarrasopone, C., Fässler, R., Muona, A., Ilves, M., Ruskoaho, H., Takala, T. E. S., & Pihlajaniemi, T. (2001). Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.3.1194
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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