The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
Open accessAbstract
Loss of growth inhibitory responses to the cytokine transforming growth factor β (TGF-β) in cancer cells may result from mutational inactivation of TGF-β receptors or their signal transducers, the Smad transcription factors. In breast cancer, however, loss of TGF-β growth inhibition often occurs without a loss of these signaling components. A genome-wide analysis of rapid TGF-β gene responses in MCF-10A human mammary epithelial cells and MDA-MB-231 breast cancer cells shows that c- myc repression, a response that is key to the TGF-β program of cell cycle arrest, is selectively lost in the cancer cell line. Transformation of MCF-10A cells with c-Ha- ras and c -erbB2 oncogenes also led to a selective loss of c- myc repression and cell cycle arrest response. TGF-β stimulation of epithelial cells rapidly induces the formation of a Smad complex that specifically recognizes a TGF-β inhibitory element in the c- myc promoter. Formation of this complex is deficient in the oncogenically transformed breast cells. These results suggest that a Smad complex that specifically mediates c- myc repression is a target of oncogenic signals in breast cancer.
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TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
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Self-citationTGF-β Family Signaling in the Control of Cell Proliferation and Survival
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TGF-β – an excellent servant but a bad master
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Metadata
- Authors
- Chen, C.-R., Kang, Y., & Massagué, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-30
- Volume
- 98
- Issue
- 3
- Pages
- 992-999
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060810914
- Cited by
- 320
- References
- 73
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, C.-R., Kang, Y., & Massagué, J. (2001). Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.3.992
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