The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER
Open accessAbstract
In the present report we describe a heretofore unrecognized role for a Jak/STAT signaling pathway, namely the stimulation of expression of the aromatase P450 (CYP19) gene, and hence of estrogen biosynthesis, in human adipose tissue. Expression of this gene in adipose tissue as well as in adipose stromal cells maintained in the presence of serum and glucocorticoids is regulated by a distal TATA-less promoter, I.4, which contains a glucocorticoid response element, an Sp1 binding site, and an interferon-gamma activation site (GAS) element. The stimulatory action of serum (in the presence of dexamethasone) can be replaced by interleukin (IL)-11, leukemia inhibitory factor, and oncostatin-M, as well as by IL-6, providing the IL-6 soluble receptor is also present. Stimulation of the cells by these factors led to rapid phosphorylation of Jak1, but not Jak2 or Jak3, on tyrosine residues. STAT3 but not STAT1 was also phosphorylated and bound to the GAS element in the I.4 promoter region. When regions of this promoter were fused upstream of the chloramphenicol acetyltransferase reporter gene and transfected into the cells, mutagenesis or deletion of the GAS element led to complete loss of reporter gene expression. Since adipose tissue is the major site of estrogen biosynthesis in men and in postmenopausal women, this pathway involving a Jak/STAT signaling mechanism acting together with glucocorticoids and Sp1 appears to be the principal means whereby estrogen biosynthesis is regulated in the elderly.
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Cites
Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., et al. (1994) · Science · doi:10.1126/science.8272873 · Cited by 979
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Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system
ROSELLI, C. E., HORTON, L. E., & RESKO, J. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2471 · Cited by 415
Mahendroo, M. S., Mendelson, C. R., & Simpson, E. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36538-x · Cited by 304
Self-citationConversion of Androgens to Estrogens in Cirrhosis of the Liver1
GORDON, G. G., OLIVO, J., RAFII, F., & SOUTHREN, A. L. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-6-1018 · Cited by 268
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Self-citationBulun, S. E. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.2.428 · Cited by 188
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Estrogen production and action
Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834
Self-citationSimpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K., Britt, K., Speed, C., & Jones, M. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081601.142703 · Cited by 773
Self-citationMolecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620
Role of cytokines in endometriosis
Harada, T., Iwabe, T., & Terakawa, N. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01816-7 · Cited by 567
Bulun, S. E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., et al. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.3.6 · Cited by 531
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Metadata
- Authors
- Zhao, Y., Nichols, J. E., Bulun, S. E., Mendelson, C. R., & Simpson, E. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 270
- Issue
- 27
- Pages
- 16449-16457
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1977137328
- Cited by
- 227
- References
- 7
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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