The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Xenobiotic-inducible Transcription of Cytochrome P450 Genes
Open accessAbstract
Numerous foreign chemicals (xenobiotics) confront us daily; such compounds often are lipophilic and may accumulate to toxic levels unless they are metabolized to water-soluble products that can be readily excreted. A cytochrome P450 enzyme(s) often catalyzes the initial step in such detoxification pathways. Multiple forms of cytochrome P450 exist; these enzymes are notable for their broad and overlapping substrate specificities. Although P450s usually mediate detoxification reactions, under some circumstances they activate their substrates to carcinogenic, mutagenic, and/or cytotoxic products.
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Citations
Cites
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895
Jain, S., Dolwick, K. M., Schmidt, J. V., & Bradfield, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31725-3 · Cited by 164
Cited by
Induction of Drug Metabolism: The Role of Nuclear Receptors
Handschin, C., & Meyer, U. A. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.2 · Cited by 470
Denison, M. S., & Heath-Pagliuso, S. (1998) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/pl00002973 · Cited by 258
Self-citationHakkola, J., Pelkonen, O., Pasanen, M., & Raunio, H. (1998) · Critical Reviews in Toxicology · doi:10.1080/10408449891344173 · Cited by 229
Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways
Chan, W. K., Yao, G., Gu, Y.-Z., & Bradfield, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12115 · Cited by 221
Orphan Nuclear Receptors: The Exotics of Xenobiotics
Xie, W., & Evans, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100033200 · Cited by 210
Metadata
- Authors
- Denison, M. S., & Whitlock, J. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 270
- Issue
- 31
- Pages
- 18175-18178
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2090641061
- Cited by
- 354
- References
- 3
- FWCI
- 24.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Denison, M. S., & Whitlock, J. P. (1995). Xenobiotic-inducible Transcription of Cytochrome P450 Genes. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.31.18175
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
