The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals
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The AhR can bind and be activated by a large number of structurally diverse chemicals.
“While the AhR can bind and be activated by a large number of structurally diverse chemicals (4-6), the highest affinity ligands include halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8tetrachlorodibenzop -dioxin (TCDD, dioxin), and polycyclic aromatic hydrocarbons (PAHs), both widespread classes of environmental contaminants (4,7).”
From Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis (2007) · cites this paper as [5]
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- Authors
- Denison, M. S., & Heath-Pagliuso, S.
- Affiliations
- University of California, Davis (US)
- ORCID
- Denison, M. S.
- Venue
- Bulletin of Environmental Contamination and Toxicology
- Published
- 1998-11
- Volume
- 61
- Issue
- 5
- Pages
- 557-568
- ISSN
- 0007-4861 (ISSN-L)
- OpenAlex
- W1965830185
- Cited by
- 258
- References
- 36
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 4 · 2017: 10 · 2016: 13 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 14
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Bulletin of Environmental Contamination and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01es007072-04)
- National Institute of Environmental Health Sciences (ES 07685, R01ES007685, ES-07072, ES05707)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- Ah receptor, aryl hydrocarbon receptor, xenobiotic metabolism, chemical toxicity, environmental pollutants, gene expression regulation
- MeSH terms
- Animals, Humans, Hydrocarbons, Halogenated, Xenobiotics, Receptors, Aryl Hydrocarbon
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