The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A Second Osmosensing Signal Transduction Pathway in Yeast
Open accessAbstract
Yeast cells respond to hypertonic shock by activation of a (MAP) mitogen-activated protein kinase cascade called the (HOG) high osmolarity glycerol response pathway. How yeast respond to hypotonic shock is unknown. Results of this investigation show that a second MAP kinase cascade in yeast called the protein kinase C1 (PKC1) pathway is activated by hypotonic shock. Tyrosine phosphorylation of the PKC1 pathway MAP kinase increased rapidly in cells following a shift of the external medium to lower osmolarity. The intensity of the response was proportional to the magnitude of the decrease in extracellular osmolarity. This response to hypotonic shock required upstream protein kinases of the PKC1 pathway. Increasing external osmolarity inhibited tyrosine phosphorylation of the PKC1 pathway MAP kinase, a response that was blocked by BCK1-20, a constitutively active mutant in an upstream protein kinase. These results indicate that yeast contain two osmosensing signal transduction pathways, the HOG pathway and the PKC1 pathway, that respond to hypertonic and hypotonic shock, respectively.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,664
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J.-D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,646
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,139
Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., & Nebreda, A. R. (1994) · Cell · doi:10.1016/0092-8674(94)90277-1 · Cited by 1,674
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248
Self-citationA two-component system that regulates an osmosensing MAP kinase cascade in yeast
Maeda, T., Wurgler-Murphy, S. M., & Saito, H. (1994) · Nature · doi:10.1038/369242a0 · Cited by 1,076
Payne, D. M., Rossomando, A. J., Martino, P., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., & Sturgill, T. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08021.x · Cited by 1,040
Albertyn, J., Hohmann, S., Thevelein, J. M., & Prior, B. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.4135 · Cited by 731
Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor
Maeda, T., Takekawa, M., & Saito, H. (1995) · Science · doi:10.1126/science.7624781 · Cited by 640
Cited by
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,767
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
The extended protein kinase C superfamily
MELLOR, H., & PARKER, P. J. (1998) · Biochemical Journal · doi:10.1042/bj3320281 · Cited by 1,538
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
Self-citationOn the Trail of a Cereal Killer: Exploring the Biology of Magnaporthe grisea
Talbot, N. J. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090957 · Cited by 962
Metadata
- Authors
- Davenport, K. R., Sohaskey, M., Kamada, Y., Levin, D. E., & Gustin, M. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 270
- Issue
- 50
- Pages
- 30157-30161
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1588192538
- Cited by
- 280
- References
- 42
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Davenport, K. R., Sohaskey, M., Kamada, Y., Levin, D. E., & Gustin, M. C. (1995). A Second Osmosensing Signal Transduction Pathway in Yeast. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.50.30157
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
