The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+
Open accessAbstract
ADP-ribosyl cyclase catalyzes the cyclization of NAD+ to produce cyclic ADP-ribose (cADPR), which is emerging as an endogenous regulator of the Ca(2+)-induced Ca2+ release mechanism in cells. CD38 is a lymphocyte differentiation antigen which has recently been shown to be a bifunctional enzyme that can synthesize cADPR from NAD+ as well as hydrolyze cADPR to ADP-ribose. In this study, we show that both the cyclase and CD38 can also catalyze the exchange of the nicotinamide group of NADP+ with nicotine acid (NA). The product is nicotinic acid adenine dinucleotide phosphate (NAADP+), a metabolite we have previously shown to be potent in Ca2+ mobilization (Lee, H. C., and Aarhus, R. (1995) J. Biol. Chem. 270, 2152-2157). The switch of the catalysis to the exchange reaction requires acidic pH and NA. The half-maximal effective concentration of NA is about 5 mM for both the cyclase and CD38. In the absence of NA or at neutral pH, the cyclase converts NADP+ to another metabolite, which is identified as cyclic ADP-ribose 2'-phosphate. Under the same conditions, CD38 converts NADP+ to ADP-ribose 2'-phosphate instead, which is the hydrolysis product of cyclic ADP-ribose 2'-phosphate. That two different products of ADP-ribosyl cyclase and CD38, cADPR and NAADP+, are both involved in Ca2+ mobilization suggests a crucial role of these enzymes in Ca2+ signaling.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazan, J. F., Lund, F. E., Santos-Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 736
Self-citationCa 2+ -Induced Ca 2+ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose
Galione, A., Lee, H. C., & Busa, W. B. (1991) · Science · doi:10.1126/science.1909457 · Cited by 618
Clapper, D. L., Walseth, T. F., Dargie, P. J., & Lee, H. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47970-7 · Cited by 569
Self-citationStructural Determination of a Cyclic Metabolite of NAD+ with Intracellular Ca2+-mobilizing Activity
Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N., & Clapper, D. L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94230-4 · Cited by 480
Self-citationLee, H. C., & Aarhus, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2152 · Cited by 475
Self-citationADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.
Lee, H. C., & Aarhus, R. (1991) · Cell Regulation · doi:10.1091/mbc.2.3.203 · Cited by 352
Self-citationRelease of Ca 2+ from Individual Plant Vacuoles by Both InsP 3 and Cyclic ADP-Ribose
Allen, G. J., Muir, S. R., & Sanders, D. (1995) · Science · doi:10.1126/science.7732384 · Cited by 345
Jackson, D. G., & Bell, J. I. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.7.2811 · Cited by 343
Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., & Okamoto, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74275-6 · Cited by 273
Cited by
NAD+ metabolism in health and disease
Belenky, P., Bogan, K. L., & Brenner, C. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.006 · Cited by 981
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862
Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Sakurai, Y., Kolokoltsov, A. A., Chen, C.-C., Tidwell, M. W., Bauta, W. E., Klugbauer, N., Grimm, C., Wahl-Schott, C., Biel, M., & Davey, R. A. (2015) · Science · doi:10.1126/science.1258758 · Cited by 555
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 531
Metadata
- Authors
- Aarhus, R., Graeff, R. M., Dickey, D. M., Walseth, T. F., & Hon, C. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 270
- Issue
- 51
- Pages
- 30327-30333
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001695130
- Cited by
- 416
- References
- 24
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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