The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Assembly and Cell Surface Expression of Heteromeric and Homomeric γ-Aminobutyric Acid Type A Receptors
Open accessAbstract
The ability of differing subunit combinations of gamma-aminobutyric acid type A (GABAA) receptors produced from murine alpha 1, beta 2, and gamma 2L subunits to form functional cell surface receptors was analyzed in both A293 cells and Xenopus oocytes using a combination of molecular, electrophysiological, biochemical, and morphological approaches. The results revealed that GABAA receptor assembly occurred within the endoplasmic reticulum and involved the interaction with the chaperone molecules immunoglobulin heavy chain binding protein and calnexin. Despite all three subunits possessing the ability to oligomerize with each other, only alpha 1 beta 2 and alpha 1 beta 2 gamma 2L subunit combinations could produce functional surface expression in a process that was not dependent on N-linked glycosylation. Single subunits and the alpha 1 gamma 2L and beta 2 gamma 2L combinations were retained within the endoplasmic reticulum. These results suggest that receptor assembly occurs by defined pathways, which may serve to limit the diversity of GABAA receptors that exist on the surface of neurons.
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Hammond, C., Braakman, I., & Helenius, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.913 · Cited by 841
Cited by
HEK293 cell line: A vehicle for the expression of recombinant proteins
Thomas, P., & Smart, T. G. (2005) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2004.08.014 · Cited by 771
Self-citationGABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
Jacob, T. C., Moss, S. J., & Jurd, R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2370 · Cited by 695
Self-citationHevers, W., & Lüddens, H. (1998) · Molecular Neurobiology · doi:10.1007/bf02741459 · Cited by 489
Harkin, L. A., Bowser, D. N., Dibbens, L. M., Singh, R., Phillips, F., Wallace, R. H., Richards, M. C., Williams, D. A., Mulley, J. C., Berkovic, S. F., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338710 · Cited by 441
GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Luscher, B., Fuchs, T., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 434
Metadata
- Authors
- Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G., & Moss, S. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 271
- Issue
- 1
- Pages
- 89-96
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1973238622
- Cited by
- 333
- References
- 1
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G., & Moss, S. J. (1996). Assembly and Cell Surface Expression of Heteromeric and Homomeric γ-Aminobutyric Acid Type A Receptors. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.1.89
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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