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Cited by 695Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

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Jacob, Tija C., Moss, Stephen J., Jurd, Rachel·2008·Nature Reviews Neuroscience
DOI 10.1038/nrn2370PMC PMC2709246
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Abstract

GABA (gamma-aminobutyric acid) type A receptors (GABA(A)Rs) mediate most fast synaptic inhibition in the mammalian brain, controlling activity at both the network and the cellular levels. The diverse functions of GABA in the CNS are matched not just by the heterogeneity of GABA(A)Rs, but also by the complex trafficking mechanisms and protein-protein interactions that generate and maintain an appropriate receptor cell-surface localization. In this Review, we discuss recent progress in our understanding of the dynamic regulation of GABA(A)R composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABA(A)R trafficking occur.

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Cited by

Sorted by citations

Authors
Jacob, T. C., Moss, S. J., & Jurd, R.
Affiliations
  • University of Pennsylvania (US)
  • University College London (GB)
Corresponding author
Moss, Stephen J.
ORCID
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2008-05
Volume
9
Issue
5
Pages
331-343
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn2370
PMC
PMC2709246
OpenAlex
W2014271878
Cited by
695
References
3
Citations by year
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FWCI
3.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust
  • National Institute of Neurological Disorders and Stroke (NS046478, R01NS051195, P01NS054900, R01NS048045, NS 056359, NS 051195, R01NS056359, R21NS080064, R01NS081986, R01NS047478, NS-048045, R01NS046478)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
GABAA receptor, receptor trafficking, neuronal inhibition, synaptic inhibition, extrasynaptic receptors, protein-protein interaction, receptor lateral diffusion, epilepsy, schizophrenia, GABAergic neurotransmission
MeSH terms
Animals, Epilepsy, Humans, Models, Neurological, Neural Inhibition, Neurons, Receptors, GABA-A, Synapses, Protein Transport

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