STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

Hunter, T. R. (1995) · Cell · doi:10.1016/0092-8674(95)90405-0 · Cited by 2,961

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

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Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

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TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

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Differentiation and proliferation of hematopoietic stem cells

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CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

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A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

Descombes, P., & Schibler, U. (1991) · Cell · doi:10.1016/0092-8674(91)90531-3 · Cited by 977

Jaks and Stats in signaling by the cytokine receptor superfamily.

Ihle, J., & Kerr, I. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89000-9 · Cited by 953

KLF6 and HSF4 transcriptionally regulate multidrug resistance transporters during inflammation

Ho, E. A., & Piquette‐Miller, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.090 · Cited by 12

Prolactin-Independent Modulation of the β-Casein Response Element by Erk2 MAP Kinase1MAP–mitogen-activated protein; PRL–Prolactin; IFN–interferons; IL–interleukins; GH–growth hormone; EGF–epidermal growth factor; PDGF–platelet-derived growth factor; EPO–erythropoietin; GM-CSF–granulocyte-macrophage colony stimulating factor; CSF-1–colony-stimulating factor-1; HTLV-I–human T cell lymphotrophic virus I; PLSP–Pro-Leu-Ser-Pro; EGF–epidermal growth factor.1

Gao, J., & Horseman, N. D. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00067-9 · Cited by 12

Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils

Epling‐Burnette, P. K., Garcia, R., Bai, F., Ismail, S., Loughran, T. P., Djeu, J. Y., Jove, R., & Sheng, W. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(02)00522-1 · Cited by 12

Constant Splice-Isoform Ratios in Human Lymphoblastoid Cells Support the Concept of a Splico-Stat

Kramer, M., Huse, K., Menzel, U., Backhaus, O., Rosenstiel, P. C., Schreiber, S., Hampe, J., & Platzer, M. (2011) · Genetics · doi:10.1534/genetics.110.125096 · Cited by 10

Transcriptional Regulator CTR9 Inhibits Th17 Differentiation via Repression of IL-17 Expression

Yoo, H.-S., Choi, Y., Ahn, N., Lee, S., Kim, W., Jang, M. S., Jang, M. H., Kim, D. K., & Yoo, J.-Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1201952 · Cited by 10

Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells

Tano, V., Jans, D. A., & Bogoyevitch, M. A. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.054 · Cited by 10

STAT isoforms: mediators of STAT specificity or leukemogenesis?

Ilaria, R. L. (2001) · Leukemia Research · doi:10.1016/s0145-2126(01)00003-0 · Cited by 8

Beyond the gene: decoding alternative isoforms

Mattioli, K., & Bulyk, M. L. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.11.003 · Cited by 9

Proteomics of Eosinophil Activation

Mosher, D. F., Wilkerson, E., Turton, K. B., Hebert, A. S., & Coon, J. J. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00159 · Cited by 7

Dominant-Negative Proteins in Herpesviruses – From Assigning Gene Function to Intracellular Immunization

Mühlbach, H., Mohr, H., Ruzsics, Z., & Koszinowski, U. H. (2009) · Viruses · doi:10.3390/v1030420 · Cited by 7

A novel splicing variant form suppresses the activity of full‐length signal transducer and activator of transcription 5A

Watanabe, Y., Ikegawa, M., Naruse, Y., & Tanaka, M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07339.x · Cited by 6

[Advances of the correlation between JAK-STAT3 signaling pathway and the biological behavior of non-small cell lung cancer].

Yu, Y., & Wang, Z. (2010) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2010.02.16 · Cited by 6

The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction

Menon, P. R., Doudin, A., Gregus, A., Wirths, O., Staab, J., & Meyer, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119118 · Cited by 6

Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala)

Wang, J., Sun, Q., Wu, J., Tian, W., Wang, H., & Liu, H. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104484 · Cited by 7

CSF-1 and Interferon-γ Act Synergistically to Promote Differentiation of FDC-P1 Cells into Macrophages

Novak, U., Nicholson, S. E., Bourette, R. P., Rohrschneider, L. R., Alexander, W. S., & Paradiso, L. (1998) · Growth Factors · doi:10.3109/08977199809002114 · Cited by 6

G-CSF Induces Apoptosis of a Human Acute Promyelocytic Leukemia Cell Line, UF-1. Possible Involvement of Stat3 Activation and Altered Bax Expression.

Yoshinari, M., Imaizumi, M., Satō, A., Minegishi, M., Fujii, K., Suzuki, H., Miura, T., Funato, T., Saito, T., Chikaoka, S., et al. (1999) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.189.71 · Cited by 6

Ultraviolet radiation and 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced interaction of mouse epidermal protein kinase Cε with Stat3 involve integration with ERK1/2

Sand, J. M., Hafeez, B. B., Aziz, M. H., Siebers, E. M., Dreckschmidt, N. E., & Verma, A. K. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20776 · Cited by 5

Signaling Chains

Teiten, M.-H., Blasius, R., Morceau, F., Diederich, M. F., & Dicato, M. A. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00083-3 · Cited by 5

Identification of two Stat3 variants lacking a transactivation domain in grass carp: New insights into alternative splicing in the modification of teleost Stat3 signaling

Wang, X., Du, L., He, W., Zhang, A., YANG, K. Y., & Zhou, H. Y. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.03.022 · Cited by 5

Identification of a splice variant of the metal-responsive transcription factor MTF-1 in common carp

Ferencz, Á., & Hermesz, E. (2009) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2009.03.006 · Cited by 5

Phospho- and Unphospho-STATs in Signal Transduction and Gene Regulation (STAT)

Lim, S. J., & Li, W. X. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_636 · Cited by 5

Atovaquone and selinexor as a novel combination treatment option in acute myeloid leukemia

Weiß, S. A. I., Moser, B., Witalisz‐Siepracka, A., Edtmayer, S., Holzer, A., Heindl, K., Casanova, E., Podar, K., & Stoiber, D. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217501 · Cited by 4

Transcription Factors, Cofactors and Target Genes Mediating Prolactin Signals

Shemanko, C. S., & Groner, B. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1683-5_19 · Cited by 4

Distinctive Roles and Molecular Regulation of CTP:Phosphoethanolamine Cytidylyltransferase Alpha and Gamma Splice Variants

Pavlovic, Z. (2014) · The Atrium (University of Guelph) · Cited by 4

Bacterial Expression, Purification, and Crystallization of Tyrosine Phosphorylated STAT Proteins

Baudin, F., & Müller, C. W. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-242-1_21 · Cited by 3

STAT3 (signal transducer and activator of transcription 3)

Cochran, B. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/38096 · Cited by 3

Alterations of Mitochondrial Respiration and Complex I Activity in Mononucleate Cells from Psoriatic Patients: Possible Involvement of GRIM-19-STAT3α/β

Scrima, R. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000184 · Cited by 2

Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

Chan, S.-H., Leu, W., Swain, S. P., Hsu, J., Hou, D., & Guh, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072470 · Cited by 3

STAT3 and Transactivation of Steroid Hormone Receptors

Lee, S. O., & Gao, A. C. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)70011-x · Cited by 3

STAT Proteins as Molecular Targets for Cancer Therapy

Buettner, R., Kortylewski, M., Pardoll, D. M., Yu, H., & Jove, R. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_41 · Cited by 3

RNA binding protein CUGBP2/ETR-3 regulates STAT3 alternative splicing

Kise, M., Masaki, S., Kataoka, N., & Suzuki, K. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151000 · Cited by 2

Modeling to Optimize Terminal Stem Cell Differentiation

Gallicano, G. I. (2013) · Scientifica · doi:10.1155/2013/574354 · Cited by 2

Identification of Entinostat as a Novel Modifier of STAT3 Pre-mRNA Alternative Splicing

Kise, M., Masaki, S., Kataoka, N., & Suzuki, K. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00404 · Cited by 2

Surface morphology gradients

Künzler, T. P. (2007) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-005420464 · Cited by 2

Signaling through the Jak-Stat pathway: Regulation of tyrosine kinase activity

Saharinen, P. (2002) · Työväentutkimus Vuosikirja · Cited by 2

REGULATION OF STAT5 ACTIVATION

Paukku, K. (2003) · Työväentutkimus Vuosikirja · Cited by 1

Human heart failure: our current STATus of knowledge

VANEMPEL, V., & Windt, L. J. D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00825-8 · Cited by 2

New Targets for Future Asthma Therapy

Barnes, P. J. (1999) · CRC Press eBooks · doi:10.1201/b14830-14 · Cited by 2

Signal transducer and activator of transcription 3β in pancreatic cancer

Dettlaff‐Pokora, A., & Kostro, J. (2010) · Open Life Sciences · doi:10.2478/s11535-010-0029-x · Cited by 1

Early Stage Oral Squamous Cell Carcinoma: Use of Signal Transducer and Activator of Transcription 3 as a Risk Factor for Poor Diagnosis

Shah, N. G., & Trivedi, T. I. (2009) · Springer eBooks · doi:10.1007/978-90-481-3186-0_17 · Cited by 1

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Turton, K. B., Esnault, S. J., Delain, L. P., & Mosher, D. F. (2016) · Journal of Visualized Experiments · doi:10.3791/54473 · Cited by 1

Alternative Splicing of Pre-mRNA Matters in Oral Diseases

Yue, M., & Jia, R. (2024) · Current Gene Therapy · doi:10.2174/0115665232302948240718050212 · Cited by 1

Identification of Novel STAT3 Target Genes Associated with Oncogenesis

Haviland, R. (2011) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1

STAT PROTEIN REGULATION OF FOXP3 EXPRESSION AND INFLAMMATORY CYTOKINE PRODUCTION IN T HELPER CELL SUBSETS

O’Malley, J. T. (2009) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1685 · Cited by 1

Novel mechanisms of Stat3 activation

Arulanandam, R. (2010) · QSpace (Queen's University Library) · Cited by 1

Rbfox1 and mir-33 regulate pleiotropic roles of JAK/STAT signalling during adult myogenesis in Drosophila melanogasterPreprint

Mukherjee, A., & Nongthomba, U. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.02.626327

Negative Regulators of STAT Function in Drosophila

Henriksen, M. A., & Betz, A. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_38

Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation

Oshiro, M. M. (2000) · UA Campus Repository (The University of Arizona)

STAT3 CONTROLS THE NEUTROPHIL MIGRATORY RESPONSE TO CXCR2 AND ITS LIGAND MIP-2 (CXCL2)

Nguyen-Jackson, H. T. (2011) · Digital Commons-TMC (Texas Medical Center)

Signal Transducer and Activator of Transcription 3 (STAT3) and Trophoblast Invasion

Js, F., Poehlmann, T. G., Suman, P., Sk, G., Schleußner, E., & Markert, U. R. (2007) · Journal für Kardiologie (Krause & Pachernegg GmbH)

The role of granulocyte colony-stimulating factor receptor signaling in neutrophil development

de Koning, J. (1999)

LOSS OF GPRC5A ENHANCES SURVIVAL IN NORMAL AND MALIGNANT LUNG EPITHELIAL CELLS BY ELICITING PERSISTENT STAT3 ACTIVATION INDUCED BY AUTOCRINE LIF

Chen, Y. (2010) · Digital Commons-TMC (Texas Medical Center)

Leukämische Fusionsproteine mit Tyrosinkinase-Aktivität induzieren eine konstitutive Aktivierung von STAT1, STAT3 und STAT5 und verursachen eine maligne Transformation von hämatopoetischen Vorläuferzellen

Pau, M. J. (2004) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2709

Studies of JAK/STAT signaling in Atlantic salmon

Sobhkhez, M. (2014) · NORA - Norwegian Open Research Archives

Expression and activation of STAT and IRF family transcription factors in mononuclear leukocytes

Lehtonen, A. (2005) · Työväentutkimus Vuosikirja

MICRO-RNA146B PROMOTES ALVEOLAR PROGENITOR CELL MAINTENANCE THROUGH PREFERENTIAL REGULATION OF STAT3B

Elsarraj, H. S. (2012) · KU ScholarWorks (The University of Kansas)

The Jak-Stat Pathway of Cytokine Signaling

Croker, B. A., & Nicola, N. A. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-747-5_3

Alterations of Mitochondrial Respiration and Complex I Activity in Mononucleate Cells from Psoriatic Patients: Possible Involvement of

Piccoli, C., Quarato, G., Ripoli, M. C., Mastrolonardo, M., & Capitanio, N. (2014)

HIF-1α and STAT3 client proteins interacting with the cancer chaperone Hsp90

Kim, H. L., Cassone, M., Otvos, L. J., & Vogiatzi, P. (2008)

STATs in Health and Disease

Liongue, C., Lewis, R. S., & Ward, A. C. (2016) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-42949-6_1

Effects of methylxanthine on STAT3 mediated regulation of cytokines involved in tumor development and tumor induced angiogenesis in melanoma cells

Kamran, M. Z. (2014) · INFLIBNET

Signal Transducer and Activator of Transcription 6 (STAT6) as a regulator of pancreatic beta cell health

Leslie, K. A. (2019) · Figshare

Operatives Trauma des Darmes bei der Osteopetrosis-Maus: Bedeutung der intestinalen Muskularis-Makrophagen

Lyutenski, B. N., Wehner, S., Lysson, M., Hirner, A., & Kalff, J. C. (2005) · Springer eBooks · doi:10.1007/3-540-26560-0_68

STAT

Lim, S. J., & Li, W. X. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_636

STAT

Lim, S. J., & Li, W. X. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_636-1

Role of JAK-STAT signaling pathway in recurrent pregnancy loss

Zubair, S., Khan, N. A., Sharma, S., Khera, N., & Rashid, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13617-7.00013-x

Oncogene functions in human cancer

Tang, J. (2010) · ResearchSpace (University of Auckland)

Interpretable machine learning enables de novo mapping of cell type-specific RNA splicing regulation from scRNA-seq data

Yang, X., & Xiang, X. (2026) · Nature Communications · doi:10.1038/s41467-026-77627-5

STAT3 isoform dynamics reveal robust splice ratio maintenance across cytokine-activated human immune cells

Ott, N., Grimbacher, B., & Andreani, V. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792173 · Cited by 1

Novel heterozygous STAT3 mutations clarify the molecular basis of the hyper IgE syndrome

Khourieh, J. (2018) · theses.fr (ABES) · doi:10.70675/94c52966z63f4z41c8za5c4z9fca65ad04d4

Cooperative roles of Pm-RORα splice variants in modulating the immune response in the pearl oyster P. f. martensii

Chen, Z., Liang, X., Chen, G., Jiao, Y., Wang, Q., Yang, C., & Deng, Y. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111588

Alternative Isoforms as Molecular Modulators of Cellular Senescence in Cancer

García-Heredia, J. M. (2026) · Cancers · doi:10.3390/cancers18203301

BindingDB Entry 50040568: Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.

BindingDB (2013) · UC San Diego · doi:10.7270/q2cj8fkk

Inhibition of the IL-6/STAT3 signaling pathway for therapeutic intervention in prostate carcinogenesis and cancer cell differentiation

Schröder, A., & Jove, R. (2013) · RWTH Publications (RWTH Aachen)

Biological Roles of the STAT Family in Cytokine Signaling

Takeda, K., & Akira, S. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_4

STAT3ß, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

Caldenhoven, E., Dijk, T. B. V., Solari, R., Armstrong, J., Raaijmakers, J. A. M., Lammers, J. J., Koenderman, L., & de Groot, R. P. (1996) · Utrecht University Repository (Utrecht University)

STAT3b, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription*

Caldenhoven, E., Dijk, T. B. V., Solari, R., Armstrong, J., Raaijmakers, J. A. M., Lammers, J. J., Koenderman, L., & de Groot, R. P. (2016)

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, I. H. W., Ng, D. C. H., Jans, D. A., & Bogoyevitch, M. A. (2012) · Biochemical Journal · doi:10.1042/bj20120941 · Cited by 63

Regulation and trafficking of the STAT3 transcription factor

Ng, H. W. I. (2017) · Figshare · doi:10.26180/4683706

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5

Caldenhoven, E., van Dijk, T., Raaijmakers, J. A. M., Lammers, J. J., Koenderman, L., & de Groot, R. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25778 · Cited by 73