A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.

Schägger, H., & von Jagow, G. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90587-2 · Cited by 11,420 · see citing works

SH2 domains recognize specific phosphopeptide sequences

Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,675 · see citing works

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

Mulligan, L. M., Kwok, J. B., Healey, C. S., Elsdon, M. J., Eng, C., Gardner, E., Love, D. R., Mole, S., Moore, J. K., Papi, L., et al. (1993) · Nature · doi:10.1038/363458a0 · Cited by 1,956 · see citing works

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Lowenstein, E. J., Daly, R. J., Batzer, A., Li, W., Margolis, B. L., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar‐Sagi, D., & Schlessinger, J. (1992) · Cell · doi:10.1016/0092-8674(92)90167-b · Cited by 1,632 · see citing works

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J. C., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T. J., & Pelicci, P. G. (1992) · Cell · doi:10.1016/0092-8674(92)90536-l · Cited by 1,326 · see citing works

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

Donis-Keller, H., Dou, S., Chi, D., Carlson, K. M., Toshima, K., Lairmore, T. C., Howe, J. R., Moley, J. F., Goodfellow, P. J., & Wells, S. A. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.7.851 · Cited by 1,298 · see citing works

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

Hofstra, R. M. W., Landsvater, R. M., Ceccherini, I., Stulp, R. P., Stelwagen, T., Luo, Y., Pasini, B., Höppener, J. W. M., van Amstel, H. K. P., Romeo, G., et al. (1994) · Nature · doi:10.1038/367375a0 · Cited by 1,143 · see citing works

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070 · see citing works

Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

Songyang, Z., Shoelson, S. E., McGlade, J. C., Olivier, P., Pawson, T. J., Bustelo, X. R., Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2777 · Cited by 881 · see citing works

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

Santoro, M. M., Carlomagno, F., Romano, A., Bottaro, D. P., Dathan, N. A., Grieco, M., Fusco, A., Vecchio, G., Matoskova, B., Kraus, M. H., et al. (1995) · Science · doi:10.1126/science.7824936 · Cited by 835 · see citing works

Mutations of the RET proto-oncogene in Hirschsprung's disease

Edery, P., Lyonnet, S., Mulligan, L. M., Pelet, A., Dow, E., Abel, L., Holder, S., Nihoul‐Feketé, C., Ponder, B. A. J., & Münnich, A. (1994) · Nature · doi:10.1038/367378a0 · Cited by 746 · see citing works

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

Romeo, G., Ronchetto, P., Luo, Y., Barone, V., Seri, M., Ceccherini, I., Pasini, B., Bocciardi, R., Lerone, M., Kääriäinen, H., et al. (1994) · Nature · doi:10.1038/367377a0 · Cited by 698 · see citing works

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

Kmiecik, T. E., & Shalloway, D. I. (1987) · Cell · doi:10.1016/0092-8674(87)90756-2 · Cited by 623 · see citing works

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

Carlson, K. M., Dou, S., Chi, D., Scavarda, N. J., Toshima, K., Jackson, C. E., Wells, S. A., Goodfellow, P. J., & Donis-Keller, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1579 · Cited by 599 · see citing works

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

Piwnica-Worms, H. M., Saunders, K. B., Roberts, T. M., Smith, A. E., & Cheng, S. H. (1987) · Cell · doi:10.1016/0092-8674(87)90757-4 · Cited by 520 · see citing works

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

Kavanaugh, W. M., & Williams, L. T. (1994) · Science · doi:10.1126/science.7527937 · Cited by 499 · see citing works

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

Kazlauskas, A., & Cooper, J. A. (1989) · Cell · doi:10.1016/0092-8674(89)90510-2 · Cited by 492 · see citing works

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H., & Hiai, H. (1988) · PubMed · Cited by 442 · see citing works

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

Asai, N., Iwashita, T., Matsuyama, M., & Takahashi, M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1613 · Cited by 339 · see citing works

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

Kavanaugh, W. M., Turck, C. W., & Williams, L. T. (1995) · Science · doi:10.1126/science.7539155 · Cited by 240 · see citing works

Loss of function effect of RET mutations causing Hirschsprung disease

Pasini, B., Borrello, M. G., Greco, A., Bongarzone, I., Luo, Y., Mondellini, P., Alberti, L., Miranda, C., Arighi, E., Bocciardi, R., et al. (1995) · Nature Genetics · doi:10.1038/ng0595-35 · Cited by 214 · see citing works

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

Morrison, D. K., Kaplan, D. R., Rhee, S. G., & Williams, L. T. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2359-2366.1990 · Cited by 203 · see citing works

Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.

Tahira, T., Ishizaka, Y., Itoh, F., Sügimura, T., & Nagao, M. (1990) · PubMed · Cited by 180 · see citing works

cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily.

Iwamoto, T., Taniguchi, M., Asai, N., Ohkusu, K., Nakashima, I., & Takahashi, M. (1993) · PubMed · Cited by 150 · see citing works

RET activation by germline MEN2A and MEN2B mutations.

Borrello, M. G., Smith, D. P., Pasini, B., Bongarzone, I., Greco, A., Lorenzo, M. J., Arighi, E., Miranda, C., Eng, C., & Alberti, L. (1995) · PubMed · Cited by 134 · see citing works

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

Takahashi, M., Buma, Y., & Hiai, H. (1989) · PubMed · Cited by 131 · see citing works

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Roussel, M. F., Shurtleff, S. A., Downing, J. R., & Sherr, C. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6738 · Cited by 113 · see citing works

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

Iwashita, T., Asai, N., Murakami, H., Matsuyama, M., & Takahashi, M. (1996) · PubMed · Cited by 110 · see citing works

The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.

Borrello, M. G., Pelicci, G., Arighi, E., Filippis, L. D., Greco, A., Bongarzone, I., Rizzetti, M. G., Pelicci, P. G., & Pierotti, M. A. (1994) · PubMed · Cited by 103 · see citing works

Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells.

Takahashi, M., Buma, Y., & Taniguchi, M. (1991) · PubMed · Cited by 99 · see citing works

Mutations of the Platelet-Derived Growth Factor Receptor That Cause a Loss of Ligand-Induced Conformational Change, Subtle Changes in Kinase Activity, and Impaired Ability To Stimulate DNA Synthesis

Fantl, W. J., Escobedo, J. A., & Williams, L. T. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.10.4473-4478.1989 · Cited by 87 · see citing works

Characterization of the ret proto-oncogene products expressed in mouse L cells.

Takahashi, M., Asai, N., Iwashita, T., Isomura, T., Miyazaki, K., & Matsuyama, M. (1993) · PubMed · Cited by 86 · see citing works

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

Morrison, D. K., Kaplan, D. R., Rhee, S. G., & Williams, L. T. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2359 · Cited by 86 · see citing works

Tyrosine 706 and 807 Phosphorylation Site Mutants in the Murine Colony-Stimulating Factor-1 Receptor Are Unaffected in Their Ability To Bind or Phosphorylate Phosphatidylinositol-3 Kinase but Show Differential Defects in Their Ability To Induce Early Response Gene Transcription

van der Geer, P., & Hunter, T. R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4698 · Cited by 57 · see citing works

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.

Fantl, W. J., Escobedo, J. A., & Williams, L. T. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.10.4473 · Cited by 52 · see citing works

Oncogenic Activation of the ret Protooncogene in Thyroid Cancer

Takahashi, M. (1995) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v6.i1.30 · Cited by 51 · see citing works

Tyrosines outside the Kinase Core and Dimerization Are Required for the Mitogenic Activity of RET/ptc2

Durick, K., Yao, V. J., Borrello, M. G., Bongarzone, I., Pierotti, M. A., & Taylor, S. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24642 · Cited by 36 · see citing works

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

Kimura, E. T., Nikiforova, M. N., Zhu, Z., Knauf, J. A., Nikiforov, Y. E., & Fagin, J. A. (2003) · PubMed · Cited by 1,510 · see citing works

Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15

Hsu, J.-Y., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A., Joo, W., Gao, Z., Fu, D., et al. (2017) · Nature · doi:10.1038/nature24042 · Cited by 616 · see citing works

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

Airaksinen, M. S., TITIEVSKY, A., & Saarma, M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0754 · Cited by 475 · see citing works

BAY 43-9006 Inhibition of Oncogenic RET Mutants

Carlomagno, F., Anaganti, S., Guida, T., Salvatore, G., Troncone, G., Wilhelm, S. M., & Santoro, M. M. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj069 · Cited by 475 · see citing works

RET tyrosine kinase signaling in development and cancer.

Arighi, E., Borrello, M. G., & Sariola, H. (2005) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2005.05.010 · Cited by 476 · see citing works

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

Ciampi, R., Knauf, J. A., Kerler, R., Gandhi, M., Zhu, Z., Nikiforova, M. N., Rabes, H. M., Fagin, J. A., & Nikiforov, Y. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23237 · Cited by 459 · see citing works

The GDNF/RET signaling pathway and human diseases

Takahashi, M. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00012-0 · Cited by 447 · see citing works

RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors

de Groot, J. W. B., Links, T. P., Plukker, J. T. M., Lips, C. J. M., & Hofstra, R. M. W. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0017 · Cited by 354 · see citing works

The RET proto-oncogene in human cancers

Jhiang, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203857 · Cited by 297 · see citing works

Therapeutic advances of targeting receptor tyrosine kinases in cancer

Tomuleasa, C., Tigu, A.-B., Munteanu, R. A., Moldovan, C. S., Kegyes, D., Onaciu, A., Gulei, D., Ghiaur, G., Einsele, H., & Croce, C. M. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01899-w · Cited by 281 · see citing works

Signaling Complexes and Protein-Protein Interactions Involved in the Activation of the Ras and Phosphatidylinositol 3-Kinase Pathways by the c-Ret Receptor Tyrosine Kinase

Besset, V., Scott, R. P., & Ibáñez, C. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006908200 · Cited by 256 · see citing works

Multiple endocrine neoplasia type 2 andRET: from neoplasia to neurogenesis

Hansford, J. R., & Mulligan, L. M. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.11.817 · Cited by 237 · see citing works

A New Hot Spot for Mutations in theretProtooncogene Causing Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2A1

Berndt, I., Reuter, M., Saller, B., Frank‐Raue, K., Groth, P., Grußendorf, M., Raue, F., Ritter, M. M., & Höppner, W. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4619 · Cited by 229 · see citing works

Transforming Ability of MEN2A-RET Requires Activation of the Phosphatidylinositol 3-Kinase/AKT Signaling Pathway

Ségouffin-Cariou, C., & Billaud, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3568 · Cited by 223 · see citing works

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

Hayashi, H., Ichihara, M., Iwashita, T., Murakami, H., Shimono, Y., Kawai, K., Kurokawa, K., Murakumo, Y., Imai, T., Funahashi, H., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203799 · Cited by 222 · see citing works

RET and neuroendocrine tumors

Ichihara, M. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00456-7 · Cited by 198 · see citing works

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

Grimm, J., Sachs, M., Britsch, S., Cesare, S. D., Schwarz, T., Alitalo, K. K., & Birchmeier, W. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102032 · Cited by 182 · see citing works

Targeting the RET Pathway in Thyroid Cancer

Wells, S. A., & Santoro, M. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2742 · Cited by 168 · see citing works

Critical and distinct roles for key RET tyrosine docking sites in renal developmentPreprint

Jain, S. R., Encinas, M., Johnson, E. M., & Milbrandt, J. (2006) · Genes & Development · doi:10.1101/gad.1387206 · Cited by 165 · see citing works

GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation

Madsen, L. W., Knauf, J. A., Gotfredsen, C., Pilling, A., Sjögren, I., Andersen, S., Andersen, L., Sietske de Boer, A., Manova, K., Barlas, A., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1864 · Cited by 161 · see citing works

How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy

Fagin, J. A. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05895 · Cited by 154 · see citing works

Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade

Melillo, R. M., Santoro, M. M., Ong, S. H., Billaud, M., Fusco, A., Hadari, Y. R., Schlessinger, J., & Lax, I. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4177-4187.2001 · Cited by 138 · see citing works

Novel Mechanism of Regulation of Rac Activity and Lamellipodia Formation by RET Tyrosine Kinase

Fukuda, T., Kiuchi, K., & Takahashi, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200643200 · Cited by 134 · see citing works

Coordinated Activation of Autophosphorylation Sites in the RET Receptor Tyrosine Kinase

Coulpier, M., Anders, J., & Ibáñez, C. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107992200 · Cited by 128 · see citing works

Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas

Castellone, M. D., Guarino, V., Falco, V. D., Carlomagno, F., Basolo, F., Faviana, P., Kruhøffer, M., Orntoft, T. F., Russell, J. P., Rothstein, J. L., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207790 · Cited by 125 · see citing works

A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia

Jijiwa, M., Fukuda, T., Kawai, K., Nakamura, A., Kurokawa, K., Murakumo, Y., Ichihara, M., & Takahashi, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8026-8036.2004 · Cited by 123 · see citing works

Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth

Crowder, R. J., Enomoto, H., Yang, M., Johnson, E. M., & Milbrandt, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403726200 · Cited by 120 · see citing works

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

Iwashita, T., Kato, M., Murakami, H., Asai, N., Ishiguro, Y., Ito, S., Iwata, Y., Kawai, K., Asai, M., Kurokawa, K., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202742 · Cited by 120 · see citing works

The RET proto‐oncogene: A molecular therapeutic target in thyroid cancer

Kodama, Y., Asai, N., Kawai, K., Jijiwa, M., Murakumo, Y., Ichihara, M., & Takahashi, M. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00023.x · Cited by 119 · see citing works

BRAF Mediates RET/PTC-Induced Mitogen-Activated Protein Kinase Activation in Thyroid Cells: Functional Support for Requirement of the RET/PTC-RAS-BRAF Pathway in Papillary Thyroid Carcinogenesis

Mitsutake, N., Miyagishi, M., Mitsutake, S., Akeno, N., Mesa, C. O., Knauf, J. A., Zhang, L., Taira, K., & Fagin, J. A. (2005) · Endocrinology · doi:10.1210/en.2005-0280 · Cited by 118 · see citing works

Central Role of RET in Thyroid CancerPreprint

Santoro, M. M., & Carlomagno, F. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009233 · Cited by 117 · see citing works

The Long and Short Isoforms of Ret Function as Independent Signaling Complexes

Pierchala, B. A., Ahrens, R. C., Crowder, R. J., Milbrandt, J., & Johnson, E. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203580200 · Cited by 115 · see citing works

Cellular Effects and Antitumor Activity of RET Inhibitor RPI-1 on MEN2A-Associated Medullary Thyroid Carcinoma

Cuccuru, G., Lanzi, C., Cassinelli, G., Pratesi, G., Tortoreto, M., Petrangolini, G., Seregni, E. C., Martinetti, A., Laccabue, D., Zanchi, C., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh184 · Cited by 115 · see citing works

Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development

Srinivas, S., Wu, Z., Chen, C. M., D’Agati, V. D., & Costantini, F. D. (1999) · Development · doi:10.1242/dev.126.7.1375 · Cited by 115 · see citing works

Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival

Encinas, M., Crowder, R. J., Milbrandt, J., & Johnson, E. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400505200 · Cited by 113 · see citing works

Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines

Miyake, I., Hakomori, Y., Shinohara, A., Gamou, T., Saito, M., Iwamatsu, A., & Sakai, R. (2002) · Oncogene · doi:10.1038/sj.onc.1205735 · Cited by 111 · see citing works

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

Kurokawa, K., Iwashita, T., Murakami, H., Hayashi, H., Kawai, K., & Takahashi, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204290 · Cited by 111 · see citing works

RET signaling pathway and RET inhibitors in human cancer

Regua, A. T., Najjar, M. K., & Lo, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.932353 · Cited by 108 · see citing works

Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

Bardelli, A., Longati, P., Gramaglia, D., Basilico, C., Tamagnone, L., Giordano, S., Ballinari, D., Michieli, P., & Comoglio, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14379 · Cited by 106 · see citing works

Multiple Endocrine Neoplasias

Hoff, A. O., Cote, G. J., & Gagel, R. F. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.377 · Cited by 105 · see citing works

MEN2A-RET-induced cellular transformation by activation of STAT3

Schuringa, J. J., Wojtachnio, K., Hagens, W. I., Vellenga, E., Buys, C. H. C. M., Hofstra, R. M. W., & Kruijer, W. (2001) · Oncogene · doi:10.1038/sj.onc.1204715 · Cited by 102 · see citing works

Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype

Peoc’h, K., Manivet, P., Beaudry, P., Attane, F., Besson, G., Hannequin, D., Delasnerie-Lauprêtre, N., & Laplanche, J. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200005)15:5 · Cited by 100 · see citing works

Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.

Pelet, A., Geneste, O., Edery, P., Pasini, A., Chappuis, S., Attié‐Bitach, T., Münnich, A., Lenoir, G., Lyonnet, S., & Billaud, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci375 · Cited by 101 · see citing works

Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.

Vita, G. D., Melillo, R. M., Carlomagno, F., Visconti, R., Castellone, M. D., Bellacosa, A., Billaud, M., Fusco, A., Tsichlis, P. N., & Santoro, M. M. (2000) · PubMed · Cited by 96 · see citing works

Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation

Murakami, H., Iwashita, T., Asai, N., Shimono, Y., Iwata, Y., Kawai, K., & Takahashi, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1186 · Cited by 96 · see citing works

Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2

Durick, K., Gill, G. N., & Taylor, S. S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2298 · Cited by 96 · see citing works

Ponatinib (AP24534) Is a Novel Potent Inhibitor of Oncogenic RET Mutants Associated With Thyroid Cancer

Falco, V. D., Buonocore, P., Muthu, M., Torregrossa, L., Basolo, F., Billaud, M., Gozgit, J. M., Carlomagno, F., & Santoro, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2672 · Cited by 95 · see citing works

Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform

Wong, A. L., Bogni, S., Kotka, P., de Graaff, E., D’Agati, V. D., Costantini, F. D., & Pachnis, V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9661-9673.2005 · Cited by 89 · see citing works

The β-Catenin Axis Integrates Multiple Signals Downstream from RET/Papillary Thyroid Carcinoma Leading to Cell Proliferation

Castellone, M. D., Falco, V. D., Rao, D. M., Bellelli, R., Muthu, M., Basolo, F., Fusco, A., Gutkind, J. S., & Santoro, M. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1982 · Cited by 87 · see citing works

Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels.

Wang, J.-W., Knauf, J., Basu, S., Puxeddu, E., Kuroda, H., Santoro, M., Fusco, A., & Fagin, J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0041 · Cited by 79 · see citing works

RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease

Asai, N., Jijiwa, M., Enomoto, A., Kawai, K., Maeda, K., Ichiahara, M., Murakumo, Y., & Takahashi, M. (2006) · Pathology International · doi:10.1111/j.1440-1827.2006.01942.x · Cited by 79 · see citing works

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

Murakami, H., Iwashita, T., Asai, N., Iwata, Y., Narumiya, S., & Takahashi, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202514 · Cited by 79 · see citing works

Characterization of Gene Expression Induced by RET with MEN2A or MEN2B Mutation

Watanabe, T., Ichihara, M., HASHIMOTO, M., Shimono, K., Shimoyama, Y., Nagasaka, T., Murakumo, Y., Murakami, H., Sugiura, H., Iwata, H., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64176-4 · Cited by 77 · see citing works

Intracellular RET signaling pathways activated by GDNF

Kawai, K., & Takahashi, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03262-1 · Cited by 76 · see citing works

The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis

Saucier, C., Khoury, H., Lai, K. V., Peschard, P., Dankort, D. L., Naujokas, M. A., Holash, J. A., Yancopoulos, G. D., Muller, W. J., Pawson, T. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308065101 · Cited by 73 · see citing works

Role of Dok1 in Cell Signaling Mediated by RET Tyrosine Kinase

Murakami, H., Yamamura, Y., Shimono, Y., Kawai, K., Kurokawa, K., & Takahashi, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202336200 · Cited by 73 · see citing works

A Two-Hit Model for Development of Multiple Endocrine Neoplasia Type 2B by RET Mutations

Iwashita, T., Murakami, H., Kurokawa, K., Kawai, K., Miyauchi, A., Futami, H., Qiao, S., Ichihara, M., & Takahashi, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2227 · Cited by 72 · see citing works

Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.

Salvatore, D., Melillo, R. M., Monaco, C., Visconti, R., Fenzi, G., Vecchio, G., Fusco, A., & Santoro, M. M. (2001) · PubMed · Cited by 71 · see citing works

RET and neuroendocrine tumors

Murakumo, Y., Jijiwa, M., Asai, N., Ichihara, M., & Takahashi, M. (2006) · Pituitary · doi:10.1007/s11102-006-0263-4 · Cited by 70 · see citing works

Functional Analysis of RET With Hirschsprung Mutations Affecting Its Kinase Domain

Iwashita, T., Kurokawa, K., Qiao, S., Murakami, H., Asai, N., Kawai, K., HASHIMOTO, M., Watanabe, T., Ichihara, M., & Takahashi, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.25515 · Cited by 69 · see citing works

Molecular Genetics of Neuroendocrine Tumors

Calender, A. (2000) · Digestion · doi:10.1159/000051850 · Cited by 69 · see citing works

Signaling through Ras Is Essential for retOncogene-induced Cell Differentiation in PC12 Cells

Califano, D., Rizzo, C., D'Alessio, A., Colucci-D'Amato, G. L., Calı̀, G., Bartoli, P. C., Santelli, G., Vecchio, G., & de Franciscis, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m905866199 · Cited by 67 · see citing works

RET/Papillary Thyroid Carcinoma Oncogenic Signaling through the Rap1 Small GTPase

Falco, V. D., Castellone, M. D., Vita, G. D., Cirafici, A. M., Hershman, J. M., Guerrero, C., Fusco, A., Melillo, R. M., & Santoro, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-0981 · Cited by 67 · see citing works

Characterization of Ret-Shc-Grb2 Complex Induced by GDNF, MEN 2A, and MEN 2B Mutations

Ohiwa, M., Murakami, H., Iwashita, T., Asai, N., Iwata, Y., Imai, T., Funahashi, H., Takagi, H., & Takahashi, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7225 · Cited by 67 · see citing works

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret

Melillo, R. M., Carlomagno, F., Vita, G. D., Formisano, P., Vecchio, G., Fusco, A., Billaud, M., & Santoro, M. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204049 · Cited by 66 · see citing works

Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.

Kawai, K., Iwashita, T., Murakami, H., Hiraiwa, N., Yoshiki, A., Kusakabe, M., Ono, K., Iida, K.-I., Nakayama, A., & Takahashi, M. (2000) · PubMed · Cited by 66 · see citing works

Signal Transduction by the Receptor Tyrosine Kinase Ret

van Weering, D. H. J., & Bos, J. L. (1998) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-46870-4_18 · Cited by 66 · see citing works

Alternative splicing results in RET isoforms with distinct trafficking properties

Richardson, D. S., Rodrigues, D. M., Hyndman, B. D., Crupi, M. J. F., Nicolescu, A. C., & Mulligan, L. M. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-02-0114 · Cited by 65 · see citing works

Thyroid C-Cell Biology and Oncogenic Transformation

Cote, G. J., Grubbs, E. G., & Hofmann, M.-C. C. (2015) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-22542-5_1 · Cited by 63 · see citing works

Tyrosines 1015 and 1062 Arein VivoAutophosphorylation Sites in Ret and Ret-Derived Oncoproteins1

Salvatore, D., Barone, M. V., Salvatore, G., Melillo, R. M., Chiappetta, G., Mineo, A., Fenzi, G., Vecchio, G., Fusco, A., & Santoro, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6882 · Cited by 62 · see citing works

The RET proto-oncogene in medullary and papillary thyroid carcinoma

Komminoth, P. (1997) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050062 · Cited by 61 · see citing works

Signal Transduction Pathways Activated by RET Oncoproteins in PC12 Pheochromocytoma Cells

Xing, S., Furminger, T. L., Tong, Q., & Jhiang, S. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4909 · Cited by 61 · see citing works

RET receptor signaling: Function in development, metabolic disease, and cancer

Takahashi, M. (2022) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.98.008 · Cited by 59 · see citing works

Regulation of neural development by glial cell line-derived neurotrophic factor family ligands

Enomoto, H. (2005) · Anatomical Science International · doi:10.1111/j.1447-073x.2005.00099.x · Cited by 57 · see citing works

A functional significance for codon third bases

Epstein, R. J., Lin, K., & Tan, T. W. (2000) · Gene · doi:10.1016/s0378-1119(00)00042-1 · Cited by 57 · see citing works

Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

Geneste, O. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.11.1989 · Cited by 57 · see citing works

Interaction of SH2-Bβ with RET is involved in signaling of GDNF-induced neurite outgrowth

Zhang, Y., Zhu, W., Wang, Y.-G., Liu, X.-J., Li, J., Liu, X., Zhang, Z., Lu, C., & He, C. (2006) · Journal of Cell Science · doi:10.1242/jcs.02845 · Cited by 56 · see citing works

Inventing Liraglutide, a Glucagon-Like Peptide-1 Analogue, for the Treatment of Diabetes and Obesity

Knudsen, L. B. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00048 · Cited by 56 · see citing works

Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase

Ishida, M., Ichihara, M., Mii, S., Jijiwa, M., Asai, N., Enomoto, A., Kato, T., Majima, A., Ping, J., Murakumo, Y., et al. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00457.x · Cited by 55 · see citing works

Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species

Heanue, T. A., & Pachnis, V. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.04.006 · Cited by 54 · see citing works

Loss of Sprouty1 Rescues Renal Agenesis Caused by Ret Mutation

Rozen, E. J., Schmidt, H., Dolcet, X., Basson, M. A., Jain, S. R., & Encinas, M. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030267 · Cited by 53 · see citing works

Activation of BMK1 via Tyrosine 1062 in RET by GDNF and MEN2A Mutation

Hayashi, Y., Iwashita, T., Murakamai, H., Kato, Y., Kawai, K., Kurokawa, K., Tohnai, I., Ueda, M., & Takahashi, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4338 · Cited by 51 · see citing works

Regulation of p27Kip1 Protein Levels Contributes to Mitogenic Effects of the RET/PTC Kinase in Thyroid Carcinoma Cells

Vitagliano, D., Carlomagno, F., Motti, M. L., Viglietto, G., Nikiforov, Y. E., Nikiforova, M. N., Hershman, J. M., Ryan, A. J., Fusco, A., Melillo, R. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3918 · Cited by 51 · see citing works

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.

Kato, M., Takeda, K., Kawamoto, Y., Iwashita, T., Akhand, A. A., Senga, T., Yamamoto, M., Sobue, G., Hamaguchi, M., Takahashi, M., et al. (2002) · PubMed · Cited by 48 · see citing works

The RET proto-oncogene: a potential target for molecular cancer therapy

Pützer, B. M., & Drosten, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.06.002 · Cited by 48 · see citing works

Ret-mediated mitogenesis requires Src kinase activity.

Melillo, R. M., Barone, M. V., Lupoli, G., Cirafici, A. M., Carlomagno, F., Visconti, R., Matoskova, B., Fiore, P. P. D., Vecchio, G., Fusco, A., et al. (1999) · PubMed · Cited by 48 · see citing works

Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells

Castellone, M. D., Celetti, A., Guarino, V., Cirafici, A. M., Basolo, F., Giannini, R., Médico, E., Kruhøffer, M., Orntoft, T. F., Curcio, F., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207322 · Cited by 46 · see citing works

Differential interaction of Enigma protein with the two RET isoforms

Borrello, M. G., Mercalli, E., Perego, C., Degl’Innocenti, D., Ghizzoni, S., Arighi, E., Eroini, B., Rizzetti, M. G., & Pierotti, M. A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00886-0 · Cited by 46 · see citing works

Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma

Giunti, S., Antonelli, A., Amorosi, A., & Santarpia, L. (2013) · International Journal of Endocrinology · doi:10.1155/2013/803171 · Cited by 45 · see citing works

Beyond RET: potential therapeutic approaches for advanced and metastatic medullary thyroid carcinoma

Santarpia, L., Ye, L., & Gagel, R. F. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02112.x · Cited by 45 · see citing works

Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1

Lanzi, C., Cassinelli, G., Cuccuru, G., Zaffaroni, N., Supino, R., Vignati, S., Zanchi, C., Yamamoto, M., & Zunino, F. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2381-8 · Cited by 45 · see citing works

The Role of Amino Acids Surrounding Tyrosine 1062 in Ret in Specific Binding of the Shc Phosphotyrosine-Binding Domain1

Ishiguro, Y., Iwashita, T., Murakami, H., Asai, N., Iida, K.-I., Goto, H., Hayakawa, T., & Takahashi, M. (1999) · Endocrinology · doi:10.1210/endo.140.9.7003 · Cited by 45 · see citing works

“Invasive-growth” signaling by the Met/HGF receptor

Bardelli, A., Pugliese, L., & Comoglio, P. M. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00026-7 · Cited by 45 · see citing works

RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho

Barone, M. V., Sepe, L., Melillo, R. M., Mineo, A., Santelli, G., Monaco, C., Castellone, M. D., Tramontano, D., Fusco, A., & Santoro, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204886 · Cited by 44 · see citing works

Expression of glial cell line‐derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma

Iwahashi, N., Nagasaka, T., Tezel, G. G., Iwashita, T., Asai, N., Murakumo, Y., Kiuchi, K., Sakata, K., Nimura, Y., & Takahashi, M. (2001) · Cancer · doi:10.1002/cncr.10169 · Cited by 42 · see citing works

Evaluation of potential mechanisms underlying genotype–phenotype correlations in multiple endocrine neoplasia type 2

Miše, N., Drosten, M., Racek, T., Tannapfel, A., & Pützer, B. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209669 · Cited by 41 · see citing works

Identification of a mouse cytoskeleton‐associated protein, CKAP2, with microtubule‐stabilizing properties

Jin, Y., Murakumo, Y., Ueno, K., HASHIMOTO, M., Watanabe, T., Shimoyama, Y., Ichihara, M., & Takahashi, M. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02187.x · Cited by 40 · see citing works

Differential Effects of Leukocyte Common Antigen-related Protein on Biochemical and Biological Activities of RET-MEN2A and RET-MEN2B Mutant Proteins

Qiao, S., Iwashita, T., Furukawa, T., Yamamoto, M., Sobue, G., & Takahashi, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008744200 · Cited by 40 · see citing works

GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin

Ouyang, J., Isnard, S., Lin, J., Fombuena, B., Peng, X., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581839 · Cited by 39 · see citing works

Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.

Takahashi, M., Asai, N., Iwashita, T., Murakami, H., & Ito, S. (1998) · PubMed · Cited by 30 · see citing works

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

Iwashita, T., Asai, N., Murakami, H., Matsuyama, M., & Takahashi, M. (1996) · PubMed · Cited by 110 · see citing works

RET activation by germline MEN2A and MEN2B mutations.

Borrello, M. G., C., S. D., I., B., Greco, A., MJ, L., Arighi, E., C, M., Eng, C., L., A., R, B., et al. (1995) · Institutional Research Information System University of Turin (University of Turin)

Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.

Salvatore, D., Melillo, R. M., Monaco, C., Visconti, R., Fenzi, G., Vecchio, G., Fusco, A., & Santoro, M. M. (2001) · PubMed · Cited by 71 · see citing works

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation(MEN2A及びMEN2B型変異を有するRet蛋白の活性化に必須なチロシン残基の同定)

Iwashita, T. (1997) · doi:10.11501/3137622