The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Physical Interaction between Human RAD52 and RPA Is Required for Homologous Recombination in Mammalian Cells
Open accessAbstract
The yeast RAD52 protein is essential for DNA double-strand break repair, and meiotic and mitotic recombination. RPA is a protein complex of three subunits (70, 34, and 11 kDa) that has been shown to be involved in DNA replication, nucleotide excision repair, and homologous recombination. Here, we demonstrate a physical interaction between human RAD52 and RPA in vivo and in vitro. In addition, the domain (amino acids 221-280) in RAD52 protein that mediates the interaction with the 34-kDa subunit of RPA was also determined. Overexpression of mutant RAD52 proteins lacking the interaction domain (amino acids 221-240, 241-260, and 261-280) failed to induce homologous recombination in monkey cells. We have previously shown that overexpression of human RAD52 induced homologous recombination in these cells. These results suggest that direct physical interactions between RAD52 and RPA are essential for homologous recombination in mammalian cells.
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Citations
Cites
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
Aboussekhra, A., Biggerstaff, M., Shivji, M. K. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protić, M., Hübscher, U., Egly, J.-M., & Wood, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90289-9 · Cited by 837
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
He, Z., Henricksen, L. A., Wold, M. S., & Ingles, C. J. (1995) · Nature · doi:10.1038/374566a0 · Cited by 389
Expression of Human RAD52 Confers Resistance to Ionizing Radiation in Mammalian Cells
Park, M. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15467 · Cited by 109
Self-citation
Cited by
Maréchal, A., & Zou, L. (2015) · Cell Research · doi:10.1038/cr.2014.147 · Cited by 465
Replication Protein A phosphorylation and the cellular response to DNA damage
Binz, S. K., Sheehan, A. M., & Wold, M. S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.028 · Cited by 299
Mechanisms of eukaryotic DNA double strand break repair
Cahill, D. (2006) · Frontiers in bioscience · doi:10.2741/1938 · Cited by 129
Wu, X., Yang, Z., Liu, Y., & Zou, Y. (2005) · Biochemical Journal · doi:10.1042/bj20050379 · Cited by 81
A structural phylogenetic tree of Rad52 and its annealase superfamily
Al-Fatlawi, A., Hossen, M. B., de Paula Lopes, S., Stewart, A. F., & Schroeder, M. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.12.012 · Cited by 3
Metadata
- Authors
- Park, M. S., Ludwig, D. L., Stigger, E., & Lee, S.-H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 271
- Issue
- 31
- Pages
- 18996-19000
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1977835715
- Cited by
- 215
- References
- 3
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Park, M. S., Ludwig, D. L., Stigger, E., & Lee, S.-H. (1996). Physical Interaction between Human RAD52 and RPA Is Required for Homologous Recombination in Mammalian Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.31.18996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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