Mechanisms of eukaryotic DNA double strand break repair

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

DNA damage and oxygen radical toxicity

Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974 · see citing works

Positional Cloning of the Werner's Syndrome Gene

Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705 · see citing works

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

A mechanism for gene conversion in fungi

Holliday, R. (1964) · Genetics Research · doi:10.1017/s0016672300001233 · Cited by 1,414 · see citing works

The Bloom's syndrome gene product is homologous to RecQ helicases

Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385 · see citing works

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385 · see citing works

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384 · see citing works

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Gottlieb, T. M., & Jackson, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90057-w · Cited by 1,233 · see citing works

Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229 · see citing works

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works

Chromosomal stability and the DNA double-stranded break connection

van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219 · see citing works

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216 · see citing works

Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

Goodhead, D. T. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550021 · Cited by 1,204 · see citing works

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166 · see citing works

A mechanism for gene conversion in fungi

Holliday, R. (2007) · Genetics Research · doi:10.1017/s0016672308009476 · Cited by 1,144 · see citing works

Sensing and repairing DNA double-strand breaks

Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,126 · see citing works

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Wu, L., & Hickson, I. D. (2003) · Nature · doi:10.1038/nature02253 · Cited by 1,087 · see citing works

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Mechanism and regulation of human non-homologous DNA end-joining

Lieber, M. R., Ma, Y., Pannicke, U., & Schwarz, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1202 · Cited by 973 · see citing works

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

Symington, L. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.630-670.2002 · Cited by 965 · see citing works

Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

Moshous, D., Callebaut, I., de Chasseval, R., Corneo, B., Cavazzana, M., Deist, F. L., Tezcan, İ., Sanal, Ö., Bertrand, Y., Philippe, N., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00309-9 · Cited by 912 · see citing works

Histone methylation in transcriptional control

Kouzarides, T. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00287-3 · Cited by 908 · see citing works

Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature · doi:10.1038/nature03114 · Cited by 884 · see citing works

The DNA-dependent protein kinasePreprint

Smith, G. C. M., & Jackson, S. P. (1999) · Genes & Development · doi:10.1101/gad.13.8.916 · Cited by 883 · see citing works

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874 · see citing works

Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death

Sonoda, E., Sasaki, M., Buerstedde, J., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi-Iwai, Y., & Takeda, S. (1998) · EMBO Journal · doi:10.1093/emboj/17.2.598 · Cited by 860 · see citing works

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37538 · Cited by 810 · see citing works

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y., & MoritaT (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6236 · Cited by 792 · see citing works

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786 · see citing works

Histone H2A variants H2AX and H2AZ

Redon, C. E., Pilch, D. R., Rogakou, E. P., Sedelnikova, O. A., Newrock, K. M., & Bonner, W. M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00282-4 · Cited by 769 · see citing works

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762 · see citing works

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758 · see citing works

Defying death after DNA damage

Rich, T., Allen, R. L., & Wyllie, A. H. (2000) · Nature · doi:10.1038/35037717 · Cited by 724 · see citing works

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

Grawunder, U., Wilm, M. S., Wu, X., Kulesza, P., Wilson, T. E., Mann, M., & Lieber, M. R. (1997) · Nature · doi:10.1038/41358 · Cited by 694 · see citing works

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

Lim, D., & Hasty, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7133 · Cited by 687 · see citing works

RecQ helicases: caretakers of the genome

Hickson, I. D. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1012 · Cited by 680 · see citing works

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

Kitao, S., Shimamoto, A., Goto, M., Miller, R. W., Smithson, W. A., Lindor, N. M., & Furuichi, Y. (1999) · Nature Genetics · doi:10.1038/8788 · Cited by 664 · see citing works

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649 · see citing works

Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair

van Attikum, H., Fritsch, O., Höhn, B., & Gasser, S. M. (2004) · Cell · doi:10.1016/j.cell.2004.11.033 · Cited by 609 · see citing works

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Mohaghegh, P. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2843 · Cited by 599 · see citing works

Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells

Johnson, R. D., & Jasin, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3398 · Cited by 590 · see citing works

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

New, J. H., Sugiyama, T., Zaitseva, E., & Kowalczykowski, S. C. (1998) · Nature · doi:10.1038/34950 · Cited by 589 · see citing works

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

Sung, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28194 · Cited by 563 · see citing works

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

Celeste, A., Difilippantonio, S., Difilippantonio, M. J., Fernández-Capetillo, Ó., Pilch, D. R., Sedelnikova, O. A., Eckhaus, M., Ried, T., Bonner, W. M., & Nussenzweig, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00567-1 · Cited by 548 · see citing works

DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

O’Driscoll, M., Cerosaletti, K. M., Girard, P.-M., Dai, Y., Stümm, M., Kysela, B. P., Hirsch, B. A., Gennery, A. R., Palmer, S. E., Seidel, J., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00408-7 · Cited by 545 · see citing works

Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase

Boddy, M. N., Gaillard, P.-H. L., McDonald, W. H., Shanahan, P., Yates, J. R., & Russell, P. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00536-0 · Cited by 545 · see citing works

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540 · see citing works

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

Savitsky, K., Sfez, S., Tagle, D. A., Ziv, Y., Sartiel, A., Collins, F. S., Shiloh, Y., & Rotman, G. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.11.2025 · Cited by 535 · see citing works

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

Liu, N., Lamerdin, J. E., Tebbs, R. S., Schild, D., Tucker, J. D., Shen, M. R., Brookman, K. W., Siciliano, M. J., Walter, C. A., Fan, W., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80078-7 · Cited by 534 · see citing works

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 528 · see citing works

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

Bassing, C. H., Chua, K. F., Sekiguchi, J., Suh, H., Whitlow, S. R., Fleming, J. C., Monroe, B., Ciccone, D. N., Yan, C. T., Vlasáková, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122228699 · Cited by 525 · see citing works

Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.

Kadyk, L. C., & Hartwell, L. H. (1992) · Genetics · doi:10.1093/genetics/132.2.387 · Cited by 522 · see citing works

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

de Jager, M., van Noort, J., van Gent, D. C., Dekker, C., Kanaar, R., & Wyman, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00381-1 · Cited by 512 · see citing works

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502 · see citing works

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

Sung, P., & Robberson, D. L. (1995) · Cell · doi:10.1016/0092-8674(95)90434-4 · Cited by 501 · see citing works

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499 · see citing works

Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.

García‐Carbonero, R., & Supko, J. G. (2002) · PubMed · Cited by 495 · see citing works

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

Frank, K. M., Sharpless, N. E., Gao, Y., Sekiguchi, J., Ferguson, D. O., Zhu, C., Manis, J. P., Horner, J. W., DePinho, R. A., & Alt, F. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80264-6 · Cited by 492 · see citing works

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482 · see citing works

Histone H2AX

Bassing, C. H., Suh, H., Ferguson, D. O., Chua, K. F., Manis, J. P., Eckersdorff, M., Gleason, M., Bronson, R. T., Lee, C., & Alt, F. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00566-x · Cited by 480 · see citing works

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaksPreprint

Chan, D. W., Chen, B. P.-C., Prithivirajsingh, S., Kurimasa, A., Story, M. D., Qin, J., & Chen, D. J. (2002) · Genes & Development · doi:10.1101/gad.1015202 · Cited by 479 · see citing works

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

Critchlow, S. E., Bowater, R. P., & Jackson, S. P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00258-2 · Cited by 474 · see citing works

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

Sutherland, B. M., Bennett, P. V., Sidorkina, O. M., & Laval, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.103 · Cited by 473 · see citing works

DNA strand annealing is promoted by the yeast Rad52 protein.

Mortensen, U. H., Bendixen, C., Šunjevarić, I., & Rothstein, R. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10729 · Cited by 472 · see citing works

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

Roth, D. B., & Wilson, J. H. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4295 · Cited by 461 · see citing works

Rad52 forms DNA repair and recombination centers during S phase

Lisby, M., Rothstein, R. J., & Mortensen, U. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121006298 · Cited by 451 · see citing works

Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

Petukhova, G. D., Stratton, S. A., & Sung, P. (1998) · Nature · doi:10.1038/30037 · Cited by 445 · see citing works

PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 445 · see citing works

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

Moreau, S., Ferguson, J. R., & Symington, L. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.556 · Cited by 445 · see citing works

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

Barnes, D. E., Stamp, G., Rosewell, I. R., Denzel, A., & Lindahl, T. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)00021-9 · Cited by 438 · see citing works

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

Povirk, L. F. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(96)00023-1 · Cited by 432 · see citing works

Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre

Lisby, M., Mortensen, U. H., & Rothstein, R. J. (2003) · Nature Cell Biology · doi:10.1038/ncb997 · Cited by 430 · see citing works

The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

Lobachev, K. S., Gordenin, D. A., & Resnick, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00614-1 · Cited by 412 · see citing works

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

Luo, G., Yao, M. S., Bender, C. F., Mills, M., Bladl, A. R., Bradley, A., & Petrini, J. H. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7376 · Cited by 408 · see citing works

Single-strand interruptions in replicating chromosomes cause double-strand breaks

Kuzminov, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131009198 · Cited by 407 · see citing works

Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

McElhinny, S. A. N., McCarville, J., Snowden, C. M., & Ramsden, D. A. (2020) · PubMed Central · doi:10.17615/5hds-gb46 · Cited by 402 · see citing works

Identification and purification of two distinct complexes containing the five RAD51 paralogsPreprint

Masson, J., Tarsounas, M., Stasiak, A. Z., Stasiak, A., Punatar, R. S., McIlwraith, M. J., Benson, F. E., & West, S. C. (2001) · Genes & Development · doi:10.1101/gad.947001 · Cited by 395 · see citing works

Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

Constantinou, A., Tarsounas, M., Karow, J., Brosh, R. M., Bohr, V. A., Hickson, I. D., & West, S. C. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd004 · Cited by 387 · see citing works

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

Dynan, W. S., & Yoo, S. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.7.1551 · Cited by 376 · see citing works

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

Dvir, A., Peterson, S., Knuth, M. W., Lu, H., & Dynan, W. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11920 · Cited by 371 · see citing works

Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG)

Fry, M., & Loeb, L. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12797 · Cited by 371 · see citing works

Role of RecA protein spiral filaments in genetic recombination

Howard-Flanders, P., West, S. C., & Stasiak, A. (1984) · Nature · doi:10.1038/309215a0 · Cited by 369 · see citing works

Collapse and repair of replication forks in Escherichia coli

Kuzminov, A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02403.x · Cited by 363 · see citing works

\nPositional cloning of the gene for Nijmegen breakage syndrome

Matsuura, S., Tauchi, H., Nakamura, A., Kondo, N., Sakamoto, S., Endo, S., Smeets, D., Sölder, B., Belohradsky, B. H., Kaloustan, V. D., et al. (1998) · Radboud Repository (Radboud University) · doi:10.1038/549 · Cited by 329 · see citing works

Interaction of DNA‐dependent protein kinase with DNA and with Ku: biochemical and atomic‐force microscopy studies

Yaneva, M., Kowalewski, T., & Lieber, M. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.16.5098 · Cited by 324 · see citing works

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

Johnson, R. D., Liu, N., & Jasin, M. (1999) · Nature · doi:10.1038/43932 · Cited by 323 · see citing works

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

Xiao, Y. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2985 · Cited by 316 · see citing works

RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

Liu, Y., Masson, J., Punatar, R. S., O’Regan, P., & West, S. C. (2004) · Science · doi:10.1126/science.1093037 · Cited by 310 · see citing works

The cellular response to general and programmed DNA double strand breaks

Bassing, C. H., & Alt, F. W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.001 · Cited by 301 · see citing works

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

Kurimasa, A., Kumano, S., Boubnov, N. V., Story, M. D., Tung, C., Peterson, S., & Chen, D. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3877 · Cited by 298 · see citing works

Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

Mahajan, K. N., Nick McElhinny, S. A., Mitchell, B. S., & Ramsden, D. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5194-5202.2002 · Cited by 293 · see citing works

Prokaryotic Homologs of the Eukaryotic DNA-End-Binding Protein Ku, Novel Domains in the Ku Protein and Prediction of a Prokaryotic Double-Strand Break Repair SystemPreprint

Aravind, L., & Koonin, E. V. (2001) · Genome Research · doi:10.1101/gr.181001 · Cited by 291 · see citing works

The MRN complex: coordinating and mediating the response to broken chromosomes

van den Bosch, M., Bree, R. T., & Lowndes, N. F. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor925 · Cited by 289 · see citing works

Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks

Brenner, D. J., & Ward, J. F. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551591 · Cited by 275 · see citing works

Ataxia-telangiectasia-like disorder (ATLD)?its clinical presentation and molecular basis

Taylor, A. M. R., Groom, A., & Byrd, P. J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.009 · Cited by 272 · see citing works

Double Strand Break Repair

Chu, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24097 · Cited by 270 · see citing works

Double-strand breaks and tumorigenesis

Pierce, A. J., Stark, J. M., Araujo, F. D., Moynahan, M. E., Berwick, M., & Jasin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02149-3 · Cited by 269 · see citing works

Sensing and responding to DNA damage

Lowndes, N. F., & Murguía, J. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00050-7 · Cited by 269 · see citing works

Human Mus81-Associated Endonuclease Cleaves Holliday Junctions In Vitro

Chen, X., Melchionna, R., Aliouat‐Denis, C., Gaillard, P.-H. L., Blasina, A., de Weyer, I. V., Boddy, M. N., Russell, P. R., Vialard, J. E., & McGowan, C. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00375-6 · Cited by 267 · see citing works

Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangePreprint

Sigurðsson, S., Komen, S. V., Bussen, W., Schild, D., Albala, J. S., & Sung, P. (2001) · Genes & Development · doi:10.1101/gad.935501 · Cited by 257 · see citing works

Crystal structure of an Xrcc4-DNA ligase IV complex.

Sibanda, B. L., Critchlow, S. E., Begun, J., Pei, X. Y., Jackson, S. P., Blundell, T. L., & Pellegrini, L. (2001) · Nature Structural Biology · doi:10.1038/nsb725 · Cited by 256 · see citing works

Rad52 Protein Associates with Replication Protein A (RPA)-Single-stranded DNA to Accelerate Rad51-mediated Displacement of RPA and Presynaptic Complex Formation

Sugiyama, T., & Kowalczykowski, S. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203494200 · Cited by 251 · see citing works

Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

Digweed, M., & Sperling, K. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.004 · Cited by 250 · see citing works

Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51–ssDNA nucleoprotein filament

Alexeev, A., Mazin, A. V., & Kowalczykowski, S. C. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb901 · Cited by 246 · see citing works

Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication

Costanzo, V., Robertson, K., Bibikova, M., Kim, E., Grieco, D., Gottesman, M., Carroll, D., & Gautier, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00294-5 · Cited by 239 · see citing works

Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase

Chen, L., Trujillo, K. M., Sung, P., & Tomkinson, A. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000491200 · Cited by 237 · see citing works

The mechanism of non-homologous end-joining: a synopsis of synapsis

Weterings, E., & van Gent, D. C. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.003 · Cited by 235 · see citing works

Break-induced replication: A review and an example in budding yeast

Kraus, E., Leung, W.-Y., & Haber, J. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151008198 · Cited by 233 · see citing works

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

Yoo, S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.24.4679 · Cited by 228 · see citing works

Clustered Damages and Total Lesions Induced in DNA by Ionizing Radiation: Oxidized Bases and Strand Breaks

Sutherland, B. M., Bennett, P. V., Sidorkina, O. M., & Laval, J. (2000) · Biochemistry · doi:10.1021/bi9927989 · Cited by 227 · see citing works

Recombinational DNA Repair of Damaged Replication Forks inEscherichia coli: Questions

Cox, M. M. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090016 · Cited by 226 · see citing works

Werner Syndrome Protein Is Regulated and Phosphorylated by DNA-dependent Protein Kinase

Yannone, S. M., Roy, S., Chan, D. W., Murphy, M. B., Huang, S., Campisi, J., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101913200 · Cited by 221 · see citing works

The role of the non‐homologous end‐joining pathway in lymphocyte development

Rooney, S., Chaudhuri, J., & Alt, F. W. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00165.x · Cited by 219 · see citing works

DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination

Kuzminov, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151260698 · Cited by 217 · see citing works

Physical Interaction between Human RAD52 and RPA Is Required for Homologous Recombination in Mammalian Cells

Park, M. S., Ludwig, D. L., Stigger, E., & Lee, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18996 · Cited by 215 · see citing works

Efficient Processing of DNA Ends during Yeast Nonhomologous End Joining

Wilson, T. E., & Lieber, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23599 · Cited by 211 · see citing works

The human Rad52 protein exists as a heptameric ring

Stasiak, A. Z., Larquet, É., Stasiak, A., Müller, S. A., Engel, A. H., Dyck, E. V., West, S. C., & Egelman, E. H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00385-7 · Cited by 210 · see citing works

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells

Jones, N. J., Cox, R., & Thacker, J. (1987) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(87)90011-3 · Cited by 207 · see citing works

Genetic Analysis of Yeast RPA1 Reveals Its Multiple Functions in DNA Metabolism

Umezu, K., Sugawara, N., Chen, C., Haber, J. E., & Kolodner, R. D. (1998) · Genetics · doi:10.1093/genetics/148.3.989 · Cited by 206 · see citing works

Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA‐PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

Wang, H., Wang, M., Wang, H., Böcker, W., & Iliakis, G. E. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20141 · Cited by 202 · see citing works

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

O’Driscoll, M., Gennery, A. R., Seidel, J., CONCANNON, P. J., & Jeggo, P. A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.025 · Cited by 201 · see citing works

Clustered DNA Damages Induced by X Rays in Human Cells

Sutherland, B. M., Bennett, P. V., Sutherland, J. C., & Laval, J. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)157[0611:cddibx]2.0.co;2 · Cited by 200 · see citing works

Evidence for Simultaneous Protein Interactions between Human Rad51 Paralogs

Schild, D., Lio, Y.-C., Collins, D. W., Tsomondo, T., & Chen, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001473200 · Cited by 199 · see citing works

Structure and function of mammalian DNA ligases

Tomkinson, A. E., & Mackey, Z. B. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00050-5 · Cited by 198 · see citing works

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase

Leber, R., Wise, T. W., Mizuta, R., & Meek, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1794 · Cited by 195 · see citing works

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

Junop, M. S., Modesti, M., Guarné, A., Ghirlando, R., Gellert, M., & Yang, W. (2000) · The EMBO Journal · doi:10.1093/emboj/19.22.5962 · Cited by 191 · see citing works

A role for FEN-1 in nonhomologous DNA end joining: The order of strand annealing and nucleolytic processing events

Wu, X., Wilson, T. E., & Lieber, M. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1303 · Cited by 185 · see citing works

Oxygen Metabolism Causes Chromosome Breaks and Is Associated with the Neuronal Apoptosis Observed in DNA Double-Strand Break Repair Mutants

Karanjawala, Z. E., Murphy, N., Hinton, D. R., Hsieh, C., & Lieber, M. R. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00684-x · Cited by 184 · see citing works

Happy Hollidays: 40th anniversary of the Holliday junction

Liu, Y., & West, S. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1502 · Cited by 181 · see citing works

Terminal deoxynucleotidyl transferase and repertoire development

Benedict, C., Gilfillan, S., Thai, T., & Kearney, J. F. (2000) · Immunological Reviews · doi:10.1111/j.1600-065x.2000.imr017518.x · Cited by 181 · see citing works

XRCC3 is required for efficient repair of chromosome breaks by homologous recombination

Brenneman, M. A., Weiss, A. E., Nickoloff, J. A., & Chen, D. J. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00002-1 · Cited by 177 · see citing works

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes

Dosanjh, M. K. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1179 · Cited by 177 · see citing works

Overlapping Functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 Nucleases in DNA Metabolism

Moreau, S., Morgan, E. A., & Symington, L. S. (2001) · Genetics · doi:10.1093/genetics/159.4.1423 · Cited by 176 · see citing works

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities

Constantinou, A., Chen, X., McGowan, C. H., & West, S. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf554 · Cited by 172 · see citing works

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

Lieber, M. R. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00245.x · Cited by 171 · see citing works

DSB repair: the yeast paradigm

Aylon, Y., & Kupiec, M. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.013 · Cited by 170 · see citing works

Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini

West, R. B., Yaneva, M., & Lieber, M. R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5908 · Cited by 170 · see citing works

DNA ligases in the repair and replication of DNA

Timson, D. J., Singleton, M. R., & Wigley, D. B. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00033-1 · Cited by 168 · see citing works

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.

Tashiro, S., Kotomura, N., Shinohara, A., Tanaka, K., Ueda, K., & Kamada, N. (1996) · PubMed · Cited by 165 · see citing works

DNA damage checkpoint in budding yeast

Longhese, M. P., Foiani, M., Muzi-Falconi, M., Lucchini, G., & Plevani, P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5525 · Cited by 162 · see citing works

Requirement for an Interaction of XRCC4 with DNA Ligase IV for Wild-type V(D)J Recombination and DNA Double-strand Break Repairin Vivo

Grawunder, U., Zimmer, D., Kulesza, P., & Lieber, M. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24708 · Cited by 162 · see citing works

MRE11/RAD50/NBS1: complex activities

Aßenmacher, N., & Hopfner, K. (2004) · Chromosoma · doi:10.1007/s00412-004-0306-4 · Cited by 161 · see citing works

Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis

Gasior, S. L., Olivares, H. A., Ear, U., Hari, D. M., Weichselbaum, R. W., & Bishop, D. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121046198 · Cited by 160 · see citing works

Nonhomologous Recombination in Mammalian Cells: Role for Short Sequence Homologies in the Joining Reaction

Roth, D. B., & Wilson, J. H. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4295-4304.1986 · Cited by 159 · see citing works

Cell cycle-dependent expression of the mouseRad51 gene in proliferating cells

Yamamoto, A., Yagi, H., Habu, T., Yoshimura, Y., Matsushiro, A., Nishimune, Y., Morita, T., Taki, T., Yoshida, K., Yamamoto, K., et al. (1996) · Molecular and General Genetics MGG · doi:10.1007/bf02174338 · Cited by 155 · see citing works

A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair Deficiency

Nicolas, N., Moshous, D., Cavazzana, M., Papadopoulo, D., de Chasseval, R., Deist, F. L., Fischer, A., & de Villartay, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.4.627 · Cited by 153 · see citing works

Tailed duplex DNA is the preferred substrate for Rad51 protein‐mediated homologous pairing

Mazin, A. V., Zaitseva, E. M., Sung, P., & Kowalczykowski, S. C. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1148 · Cited by 152 · see citing works

Branch Migration and Holliday Junction Resolution Catalyzed by Activities from Mammalian Cells

Constantinou, A., Davies, A. A., & West, S. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00210-0 · Cited by 149 · see citing works

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

Grawunder, U., Zimmer, D., & Lieber, M. R. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00349-1 · Cited by 149 · see citing works

The human Rad51 protein: polarity of strand transfer and stimulation by hRP‐A

Baumann, P., & West, S. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5198 · Cited by 147 · see citing works

Identification of bacterial homologues of the Ku DNA repair proteins

Doherty, A. J., Jackson, S. P., & Weller, G. R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02589-3 · Cited by 147 · see citing works

Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder

GERMAN, J. L., Crippa, L., & Bloom, D. (1974) · Chromosoma · doi:10.1007/bf00290993 · Cited by 146 · see citing works

The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase

Swagemakers, S. M. A., Essers, J., de Wit, J., Hoeijmakers, J. H. J., & Kanaar, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28292 · Cited by 146 · see citing works

The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA

Ristić, D., Wyman, C., Paulusma, C. C., & Kanaar, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151056798 · Cited by 145 · see citing works

Defective neurogenesis resulting from DNA ligase IV deficiency requires AtmPreprint

Lee, Y., Barnes, D. E., Lindahl, T. L., & McKinnon, P. J. (2000) · Genes & Development · doi:10.1101/gad.837100 · Cited by 144 · see citing works

Alteration of N-Terminal Phosphoesterase Signature Motifs Inactivates Saccharomyces cerevisiae Mre11

Bressan, D. A., Olivares, H. A., Nelms, B. E., & Petrini, J. H. J. (1998) · Genetics · doi:10.1093/genetics/150.2.591 · Cited by 140 · see citing works

Studies of the Interaction between Rad52 Protein and the Yeast Single-Stranded DNA Binding Protein RPA

Hays, S. L., Firmenich, A. A., Massey, P., Banerjee, R. R., & Berg, P. R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4400 · Cited by 138 · see citing works

Identification of a Novel HumanRAD51Homolog,RAD51B

Albala, J. S., Thelen, M. P., Prange, C. K., Fan, W., Christensen, M. L., Thompson, L. H., & Lennon, G. G. (1997) · Genomics · doi:10.1006/geno.1997.5062 · Cited by 131 · see citing works

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

Yu, Y., Wang, W., Ding, Q., Ye, R., Chen, D., Merkle, D., Schriemer, D. C., Meek, K., & Lees‐Miller, S. P. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00143-5 · Cited by 131 · see citing works

Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells

Liu, N. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.1009 · Cited by 129 · see citing works

In vivo assembly and disassembly of Rad51 and Rad52 complexes during double‐strand break repair

Miyazaki, T., Bressan, D. A., Shinohara, M., Haber, J. E., & Shinohara, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600091 · Cited by 125 · see citing works

Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filament

Solinger, J. A., Lutz, G., Sugiyama, T., Kowalczykowski, S. C., & Heyer, W. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4555 · Cited by 125 · see citing works

An increasingly complex code

Spotswood, H. T., & Turner, B. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16547 · Cited by 124 · see citing works

Double-strand breaks and tumorigenesis

Pierce, A. J., Stark, J. M., Araujo, F. D., Moynahan, M. E., Berwick, M., & Jasin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)82296-0 · Cited by 119 · see citing works

Defining interactions between DNA-PK and ligase IV/XRCC4

Hsu, H.-L., Yannone, S. M., & Chen, D. J. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00018-0 · Cited by 117 · see citing works

Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells

Wiese, C. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.1001 · Cited by 117 · see citing works

Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1

Cheng, W., von Kobbe, C., Opresko, P. L., Arthur, L. M., Komatsu, K., Seidman, M. M., Carney, J. P., & Bohr, V. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312770200 · Cited by 116 · see citing works

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint Response

Zhang, X., Succi, J., Feng, Z., Prithivirajsingh, S., Story, M. D., & Legerski, R. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9207-9220.2004 · Cited by 116 · see citing works

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113 · see citing works

Visualisation of human rad52 protein and its complexes with hrad51 and DNA

Dyck, E. V., Hajibagheri, N., Stasiak, A., & West, S. C. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2203 · Cited by 112 · see citing works

A Physical and Functional Interaction between Yeast Pol4 and Dnl4-Lif1 Links DNA Synthesis and Ligation in Nonhomologous End Joining

Tseng, H.-M., & Tomkinson, A. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206861200 · Cited by 111 · see citing works

The RAD51 Family Member, RAD51L3, Is a DNA-stimulated ATPase That Forms a Complex with XRCC2

Braybrooke, J. P., Spink, K. G., Thacker, J., & Hickson, I. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002075200 · Cited by 108 · see citing works

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

Karmakar, P. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf482 · Cited by 104 · see citing works

DNA polymerase λ can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4–ligase IV complex

Fan, W., & Wu, X. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.002 · Cited by 97 · see citing works

The role of the DNA double-strand break response network in meiosis

Richardson, C. A., Horikoshi, N., & Pandita, T. K. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.05.007 · Cited by 94 · see citing works

DNA Damage as the Cause of Ionizing Radiation-Induced Gene Activation

Ward, J. F. (1994) · Radiation Research · doi:10.2307/3578769 · Cited by 92 · see citing works

RAD51C Interacts with RAD51B and Is Central to a Larger Protein Complex in Vivo Exclusive of RAD51

Miller, K. A., Yoshikawa, D. M., McConnell, I. R., Clark, R., Schild, D., & Albala, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108306200 · Cited by 91 · see citing works

Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

Yonetani, Y. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki766 · Cited by 86 · see citing works

DNA Double-strand Breaks Generated by the Repair of X-ray Damage in Chinese Hamster Cells

Ahnström, G., & Bryant, P. E. (1982) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008214550761 · Cited by 85 · see citing works

Homologous Pairing and Ring and Filament Structure Formation Activities of the Human Xrcc2·Rad51D Complex

Kurumizaka, H., Ikawa, S., Nakada, M., Enomoto, R., Kagawa, W., Kinebuchi, T., Yamazoe, M., Yokoyama, S., & Shibata, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105719200 · Cited by 83 · see citing works

Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.

Jaspers, N. G. J., de Wit, J., Regulski, M., & Bootsma, D. (1982) · PubMed · Cited by 78 · see citing works

Human RAD52 Exhibits Two Modes of Self-association

Ranatunga, W. K., Jackson, D. D., Lloyd, J. A., Forget, A. L., Knight, K. L., & Borgstahl, G. E. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011747200 · Cited by 75 · see citing works

Effect of Amino Acid Substitutions in the Rad50 ATP Binding Domain on DNA Double Strand Break Repair in Yeast

Chen, L., Trujillo, K. M., Komen, S. V., Roh, D.-H., Krejčí, L., Lewis, L. K., Resnick, M. A., Sung, P., & Tomkinson, A. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410192200 · Cited by 62 · see citing works

Processing and Joining of DNA Ends Coordinated by Interactions among Dnl4/Lif1, Pol4, and FEN-1

Tseng, H.-M., & Tomkinson, A. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404492200 · Cited by 59 · see citing works

Noncomplementary DNA double-strand-break rejoining in bacterial and human cells

King, J. S., Valcarcel, E. R., Rufer, J. T., Phillips, J. W., & William, F. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.5.1055 · Cited by 56 · see citing works

Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae

Symington, L. S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.23.4649 · Cited by 56 · see citing works

Protein kinases and DNA damage

Gottlieb, T. M., & Jackson, S. P. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90138-4 · Cited by 54 · see citing works

Histone methylation in transcriptional control

(2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)81031-0 · Cited by 35 · see citing works

A 5'-3' Exonuclease From Saccharomyces cerevisiae is Required for in Vitro Recombination Between Linear DNA Molecules with Overlapping Homology

Huang, K. N., & Symington, L. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3125-3134.1993 · Cited by 34 · see citing works

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

Campbell, P. J., Stephens, P. J., Pleasance, E., O’Meara, S., Li, H., Santarius, T., Stebbings, L. A., Leroy, C., Edkins, S., Hardy, C. W., et al. (2008) · Nature Genetics · doi:10.1038/ng.128 · Cited by 812 · see citing works

Base excision repair of oxidative DNA damage and association with cancer and aging

Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works

A dynamic model for replication protein A (RPA) function in DNA processing pathways

Fanning, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl550 · Cited by 565 · see citing works

DNA Damage ResponsePreprint

Giglia‐Mari, G., Zotter, A., & Vermeulen, W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000745 · Cited by 487 · see citing works

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

Sharma, S., Doherty, K. M., & Brosh, R. M. (2006) · Biochemical Journal · doi:10.1042/bj20060450 · Cited by 245 · see citing works

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

Fattah, F. J., Lee, E. H., Weisensel, N. A., Wang, Y., Lichter, N., & Hendrickson, E. A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000855 · Cited by 244 · see citing works

The Tale of Two Domains

Abu‐Farha, M., Lambert, J., Madhoun, A. S. A., Elisma, F., Skerjanc, I. S., & Figeys, D. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700271-mcp200 · Cited by 199 · see citing works

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolutionPreprint

Bignell, G. R., Santarius, T., Pole, J. C. M., Butler, A. P., Perry, J., Pleasance, E., Greenman, C., Menzies, A. H., Taylor, S., Edkins, S., et al. (2007) · Genome Research · doi:10.1101/gr.6522707 · Cited by 195 · see citing works

Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis

Livneh, Z., Omer, Z., & Shachar, S. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10727 · Cited by 165 · see citing works

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

Banerjee, R., Russo, N., Liu, M., Basrur, V., Bellile, E. L., Palanisamy, N., Scanlon, C. S., Tubergen, E. V., Inglehart, R. C., Metwally, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5527 · Cited by 153 · see citing works

Adeno‐associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo†‡

Paulk, N. K., Wursthorn, K., Wang, Z., Finegold, M. J., Kay, M. A., & Grompe, M. (2010) · Hepatology · doi:10.1002/hep.23481 · Cited by 135 · see citing works

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

Watson, L. A., Solomon, L. A., Li, J. R., Jiang, Y. Y., Edwards, M., Shin‐ya, K., Beier, F., & Bérubé, N. G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65634 · Cited by 125 · see citing works

Picky comprehensively detects high-resolution structural variants in nanopore long reads

Gong, L., Wong, C., Cheng, W., Tjong, H., Menghi, F., Ngan, C. Y., Liu, E. T., & Wei, C. (2018) · Nature Methods · doi:10.1038/s41592-018-0002-6 · Cited by 113 · see citing works

The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more?

Ismail, I. H., & Hendzel, M. J. (2007) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20358 · Cited by 107 · see citing works

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis

Richard, D. J., Bolderson, E., & Khanna, K. K. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230902849180 · Cited by 106 · see citing works

Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses

Smith, J. A., & Daniel, R. (2006) · ACS Chemical Biology · doi:10.1021/cb600131q · Cited by 105 · see citing works

Airborne particulate matter induces oxidative damage, DNA adduct formation and alterations in DNA repair pathways

Quezada-Maldonado, E. M., Sánchez-Pérez, Y., Chirino, Y. I., & García-Cuellar, C. M. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117313 · Cited by 102 · see citing works

Chromatin remodeling in DNA double-strand break repair

Bao, Y., & Shen, X. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.02.010 · Cited by 102 · see citing works

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

Bhattacharjee, S., & Nandi, S. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0128-z · Cited by 87 · see citing works

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases

Ouyang, K. J., Woo, L. L., & Ellis, N. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.003 · Cited by 84 · see citing works

Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells

Meng, X., Qi, X., Guo, H., Cai, M., Li, C., Zhu, J., Chen, F., Guo, H., Li, J., Zhao, Y., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102703 · Cited by 83 · see citing works

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

Þorsteinsdóttir, S., Guðjόnsson, Þ., Nielsen, O. H., Vainer, B., & Seidelin, J. B. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.96 · Cited by 83 · see citing works

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

Kang, Y., Lee, C., & Seo, Y. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903578593 · Cited by 79 · see citing works

Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomesPreprint

Hillmer, A. M., Yao, F., Inaki, K., Lee, W. H., Ariyaratne, P. N., Teo, A. S. M., Woo, X. Y., Zhang, Z., Zhao, H., Ukil, L., et al. (2011) · Genome Research · doi:10.1101/gr.113555.110 · Cited by 77 · see citing works

Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Mao, P., Liu, J., Zhang, Z., Zhang, H., Liu, H., Gao, S., Rong, Y. S., & Zhao, Y. (2016) · Nature Communications · doi:10.1038/ncomms12154 · Cited by 76 · see citing works

Integration Site Selection by Retroviral Vectors: Molecular Mechanism and Clinical Consequences

Daniel, R., & Smith, J. A. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.148 · Cited by 73 · see citing works

Escherichia coli Genes and Pathways Involved in Surviving Extreme Exposure to Ionizing Radiation

Byrne, R. T., Chen, S. H., Wood, E. A., Cabot, E. L., & Cox, M. M. (2014) · Journal of Bacteriology · doi:10.1128/jb.01589-14 · Cited by 73 · see citing works

DNA repair in cancer: emerging targets for personalized therapy

Madhusudan, S., Abbotts, R., & Thompson, N. (2014) · Cancer Management and Research · doi:10.2147/cmar.s50497 · Cited by 69 · see citing works

Genetic Polymorphisms in DNA Repair Genes XRCC4 and XRCC5 and Aflatoxin B1–related Hepatocellular Carcinoma

Long, X., Zhao, D. H., Wang, C., Huang, X., Yao, J., Ma, Y., Wei, Z.-H., Liu, M., Zeng, L., Mo, X., et al. (2013) · Epidemiology · doi:10.1097/ede.0b013e31829d2744 · Cited by 70 · see citing works

Plant Desiccation Tolerance

(2007) · Wiley eBooks · doi:10.1002/9780470376881 · Cited by 70 · see citing works

DNA repair pathways and hereditary cancer susceptibility syndromes

Spry, M. L. (2007) · Frontiers in bioscience · doi:10.2741/2380 · Cited by 64 · see citing works

Chromatin dynamics during repair of chromosomal DNA double-strand breaks

Sinha, M., & Peterson, C. L. (2009) · Epigenomics · doi:10.2217/epi.09.22 · Cited by 63 · see citing works

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

Ciccone, S., Maiani, E., Bellusci, G., Diederich, M. F., & Gonfloni, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022388 · Cited by 64 · see citing works

Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance

Zhu, Y.-J., Hu, J., Hu, Y., & Liu, W. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.06.005 · Cited by 63 · see citing works

HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?

Nunnari, G., Smith, J. A., & Daniel, R. (2008) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-27-3 · Cited by 59 · see citing works

Deregulation of DNA Double-Strand Break Repair in Multiple Myeloma: Implications for Genome Stability

Herrero, A. B., Miguel, J. F. S., & Gutierrez, N. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121581 · Cited by 57 · see citing works

Repair of gaps opposite lesions by homologous recombination in mammalian cells

Adar, S., Izhar, L., Hendel, A., Geacintov, N. E., & Livneh, Z. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp632 · Cited by 56 · see citing works

RNA-induced initiation of transcriptional silencing (RITS) complex structure and function

Bhattacharjee, S., Roche, B., & Martienssen, R. A. (2019) · RNA Biology · doi:10.1080/15476286.2019.1621624 · Cited by 55 · see citing works

Biochemical Characterization of Metnase’s Endonuclease Activity and Its Role in NHEJ Repair

Beck, B. D., Lee, S.-S., Williamson, E. A., Hromas, R., & Lee, S. (2011) · Biochemistry · doi:10.1021/bi200333k · Cited by 54 · see citing works

High frequency of genomic deletions—and a duplication—in the LIS1 gene in lissencephaly: implications for molecular diagnosis

Mei, D., Lewis, R., Parrini, E., Lazarou, L., Marini, C., Pilz, D. T., & Guerrini, R. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2007.056507 · Cited by 52 · see citing works

The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates the Effects of Topoisomerase I Poisons by Suppressing Rad51 Expression in a p53-Dependent Manner

Ambrosini, G., Seelman, S. L., Qin, L., & Schwartz, G. K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2395 · Cited by 49 · see citing works

Tools for high efficiency genetic manipulation of the human pathogen Penicillium marneffei

Bugeja, H. E., Boyce, K. J., Weerasinghe, H., Beard, S., Jeziorowski, A., Pasricha, S., Payne, M., Schreider, L., & Andrianopoulos, A. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.08.003 · Cited by 48 · see citing works

Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma

Long, X., Yao, J., Zeng, Z. R., Ma, Y., Huang, X., Wei, Z.-H., Liu, M., Zhang, J., Xue, F., Zhai, B., et al. (2013) · Hepatology · doi:10.1002/hep.26311 · Cited by 47 · see citing works

Gene amplification, radiation sensitivity and DNA double-strand breaks

Mondello, C., Smirnova, A., & Giulotto, E. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.008 · Cited by 46 · see citing works

Altering nucleosomes during DNA double-strand break repair in yeast

Osley, M. A., & SHEN, X. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.09.007 · Cited by 46 · see citing works

Different fates of oocytes with DNA double-strand breaksin vitroandin vivo

Lin, F., Ma, X., Wang, Z., Wang, Z.-W., Luo, Y., Huang, L., Jiang, Z., Hu, M., Schatten, H., & Sun, Q. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945375 · Cited by 45 · see citing works

Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies

Valero, J., Berciano, M. T., Weruaga, E., Lafarga, M., & Alonso, J. R. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.08.002 · Cited by 45 · see citing works

Mutations to Ku reveal differences in human somatic cell lines

Fattah, K. R., Ruis, B. L., & Hendrickson, E. A. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.02.008 · Cited by 43 · see citing works

Molecular Population Genetics and Evolution of Drosophila Meiosis Genes

Anderson, J. A., Gilliland, W. D., & Langley, C. H. (2008) · Genetics · doi:10.1534/genetics.108.093807 · Cited by 42 · see citing works

Arabidopsis Replication Protein A 70a is Required for DNA Damage Response and Telomere Length Homeostasis

Takashi, Y., Kobayashi, Y. O., Tanaka, K., & Tamura, K. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp140 · Cited by 37 · see citing works

Profiling DNA damage and repair capacity in sea urchin larvae and coelomocytes exposed to genotoxicants

Reinardy, H. C., & Bodnar, A. G. (2015) · Mutagenesis · doi:10.1093/mutage/gev052 · Cited by 36 · see citing works

Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos

Yukawa, M., Oda, S., Mitani, H., Nagata, M., & Aoki, F. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.162 · Cited by 36 · see citing works

The Role of Mitochondria in the Radiation-Induced Bystander Effect in Human Lymphoblastoid Cells

Rajendran, S., Harrison, S. H., Thomas, R. A., & Tucker, J. D. (2010) · Radiation Research · doi:10.1667/rr2296.1 · Cited by 36 · see citing works

Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants

Johnson-Schlitz, D. M., & Engels, W. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607904103 · Cited by 36 · see citing works

Chromatin modifications and DNA double-strand breaks: the current state of play

Karagiannis, T. C., & El‐Osta, A. (2006) · Leukemia · doi:10.1038/sj.leu.2404478 · Cited by 35 · see citing works

Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy

Sinclair, P. B., Parker, H., An, Q., Rand, V., Ensor, H., Harrison, C. J., & Strefford, J. C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr159 · Cited by 33 · see citing works

The Dynamic Behavior of Chromatin in Response to DNA Double-Strand Breaks

Fernández, F. G., & Fabre, E. (2022) · Genes · doi:10.3390/genes13020215 · Cited by 33 · see citing works

Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype

Dutrannoy, V., Demuth, I., Baumann, U., Schindler, D., Konrat, K., Neitzel, H., Gillessen‐Kaesbach, G., Radszewski, J., Rothe, S., Schellenberger, M. T., et al. (2010) · Human Mutation · doi:10.1002/humu.21315 · Cited by 33 · see citing works

Optimizing the Molecular Diagnosis of GALNS: Novel Methods to Define and Characterize Morquio-A Syndrome-Associated Mutations

Caciotti, A., Tonin, R., Rigoldi, M., Ferri, L., Catarzi, S., Cavicchi, C., Procopio, E., Donati, M. A., Ficcadenti, A., Fiumara, A., et al. (2014) · Human Mutation · doi:10.1002/humu.22751 · Cited by 32 · see citing works

Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery

Oza, P., & Peterson, C. L. (2010) · Cell Cycle · doi:10.4161/cc.9.1.10317 · Cited by 31 · see citing works

Inhibitory effect of apigenin on benzo(a)pyrene-mediated genotoxicity in Swiss albino mice

Khan, T. H., Jahangir, T., Prasad, L., & Sultana, S. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.12.0013 · Cited by 31 · see citing works

Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection

Vogel, R., Seyffert, M., Strasser, R., de Oliveira, A. P., Dresch, C., Glauser, D. L., Jolinon, N., Salvetti, A., Weitzman, M. D., Ackermann, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05694-11 · Cited by 29 · see citing works

I-SceI-mediated double-strand DNA breaks stimulate efficient gene targeting in the industrial fungus Trichoderma reesei

Ouedraogo, J., Arentshorst, M., Nikolaev, I., Barends, S., & Ram, A. F. J. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6829-1 · Cited by 29 · see citing works

Transcription-coupled homologous recombination after oxidative damage

Wei, L., Levine, A. S., & Lan, L. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.009 · Cited by 29 · see citing works

Elevated Expression of Thyroid Hormone Receptor-Interacting Protein 13 Drives Tumorigenesis and Affects Clinical Outcome

Dazhi, W., Mengxi, Z., Chen, F., & Meixing, Y. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0169 · Cited by 28 · see citing works

Capture of linear fragments at a double-strand break in yeast

Haviv‐Chesner, A., Kobayashi, Y., Gabriel, A., & Kupiec, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm521 · Cited by 27 · see citing works

Inactivation of MOXD2 and S100A15A by Exon Deletion during Human Evolution

Hahn, Y., Jeong, S., & Lee, B. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm146 · Cited by 26 · see citing works

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: A post-cleavage role for AID

Zan, H., & Casali, P. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.07.003 · Cited by 26 · see citing works

HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation

Saydam, O., Saydam, N., Glauser, D. L., Pruschy, M. N., Vuong, D.-V., Hilbe, M., Jacobs, A. H., Ackermann, M., & Fraefel, C. (2007) · Gene Therapy · doi:10.1038/sj.gt.3302967 · Cited by 24 · see citing works

CREB-Binding Protein Regulates Ku70 Acetylation in Response to Ionization Radiation in Neuroblastoma

Subramanian, C., Hada, M., Opipari, A. W., Castle, V. P., & Kwok, R. P. S. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0065 · Cited by 22 · see citing works

Rad54 Oligomers Translocate and Cross-bridge Double-stranded DNA to Stimulate Synapsis

Bianco, P. R., Bradfield, J. J., Castanza, L. R., & Donnelly, A. N. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.09.052 · Cited by 22 · see citing works

Genetic Polymorphisms of DNA Repair Genes and DNA Repair Capacity Related to Aflatoxin B1 (AFB1)-Induced DNA Damages

Xia, Q., Huang, X., Xue, F., Zhang, J., Zhai, B., Kong, D. C., Wang, C., Huang, Z., & Long, X. (2013) · InTech eBooks · doi:10.5772/53967 · Cited by 20 · see citing works

Induced Pluripotent Stem Cells Are Sensitive to DNA Damage

Zhang, M., Yang, C., Liu, H., & Sun, Y. (2013) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2013.09.006 · Cited by 19 · see citing works

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?

Müther, N., Noske, N., & Ehrhardt, A. (2009) · Viruses · doi:10.3390/v1031295 · Cited by 19 · see citing works

Evolution of Models of Homologous Recombination

Haber, J. E. (2007) · Genome dynamics and stability · doi:10.1007/7050_2007_037 · Cited by 19 · see citing works

Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum

Tanori, M., Pasquali, E., Leonardi, S., Casciati, A., Giardullo, P., Stefano, I. D., Mancuso, M., Saran, A., & Pazzaglia, S. (2013) · Stem Cells · doi:10.1002/stem.1485 · Cited by 18 · see citing works

Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer

Castellanos, G., Valbuena, D. S., Pérez, E., Villegas, V. E., & Rondón‐Lagos, M. (2023) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s383759 · Cited by 18 · see citing works

Gene Targeting in Human Somatic Cells

Hendrickson, E. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-285-4_53 · Cited by 16 · see citing works

XRCC3 Depletion Induces Spontaneous DNA Breaks and p53-Dependent Cell Death

Loignon, M., Amrein, L., Dunn, M., & Aloyz, R. S. (2007) · Cell Cycle · doi:10.4161/cc.6.5.3923 · Cited by 16 · see citing works

A critical role for the C-terminus of Nej1 protein in Lif1p association, DNA binding and non-homologous end-joining

Sulek, M., Yarrington, R. M., McGibbon, G. A., Boeke, J. D., & Junop, M. S. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.07.009 · Cited by 15 · see citing works

Genome instability and DNA damage accumulation in gene-targeted mice

Nordstrand, L. M., Ringvoll, J., Larsen, E., & Klungland, A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.059 · Cited by 16 · see citing works

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

Long, X., Yao, J., Zeng, Z. R., Cen-han, H., Pinhu, L., Huang, Z.-S., Huang, Y.-Z., Ban, F., Huang, X.-Y., Yao, L., et al. (2011) · InTech eBooks · doi:10.5772/20792 · Cited by 14 · see citing works

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast

Balogun, F. O., Truman, A. W., & Kron, S. J. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.06.003 · Cited by 14 · see citing works

Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum

Tanori, M., Pasquali, E., Leonardi, S., Giardullo, P., Majo, V. D., Taccioli, G. E., Essers, J., Kanaar, R., Mullenders, L. H. F., Atkinson, M. J., et al. (2011) · Oncogene · doi:10.1038/onc.2011.178 · Cited by 14 · see citing works

The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells

Singh, R., & Winn, L. M. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.08.007 · Cited by 14 · see citing works

Molecular Carcinogenesis

Zachariadis, M., Evangelou, K., Kastrinakis, N. G., Papanagnou, P., & Gorgoulis, V. G. (2010) · Springer eBooks · doi:10.1007/978-3-540-71915-1_74 · Cited by 13 · see citing works

DNA bridging of yeast chromosomes VIII leads to near-reciprocal translocation and loss of heterozygosity with minor cellular defects

Tosato, V., Nicolini, C. A., & Bruschi, C. V. (2008) · Chromosoma · doi:10.1007/s00412-008-0187-z · Cited by 13 · see citing works

A Rehabilitation Walker with a Standing Assistance Device

Chugo, D., & Takase, K. (2009) · InTech eBooks · doi:10.5772/7390 · Cited by 11 · see citing works

Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett’s Adenocarcinoma Cells

Pal, J., Nanjappa, P., Kumar, S., Shi, J., Buon, L., Munshi, N. C., & Shammas, M. A. (2017) · Journal of Gastroenterology and Hepatology Research · doi:10.17554/j.issn.2224-3992.2017.06.687 · Cited by 10 · see citing works

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Functional characterization of the RAD51D E233G genetic variant

Nadkarni, A., Furda, A. M., Rajesh, C., McInnes, C., Ruch, R. J., & Pittman, D. L. (2009) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32831db2fd · Cited by 9 · see citing works

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Shtygasheva, A. A., Belousova, E. A., Rechkunova, N. I., Lebedeva, N. A., & Lavrik, O. I. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908110060 · Cited by 9 · see citing works

Analysis of chromatin remodeling during formation of a DNA double-strand break at the yeast mating type locus

Tsukuda, T., Trujillo, K. M., Martini, E. M.-D., & Osley, M. A. (2009) · Methods · doi:10.1016/j.ymeth.2009.02.007 · Cited by 7 · see citing works

Duplication of DNA in eukaryotic cells

Kelly, T. J., & Stillman, B. (2006) · Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) · doi:10.1101/087969766.47.1 · Cited by 7 · see citing works

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Chen, X., Wang, G., Alsayed, A. M. M., Du, Z., Liu, L., Ma, Y., Liu, P., Zhang, Q., Chen, X., Chen, W., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113203 · Cited by 5 · see citing works

Different contributions of the indirect effects of γ-rays on the cytotoxicity in M10 and XRCC4 transfected M10 cells

MIYAZAKI, N., Nakano, H., Ito, A., & Shinohara, K. (2007) · Radiation and Environmental Biophysics · doi:10.1007/s00411-007-0113-4 · Cited by 6 · see citing works

Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity

González-Vidal, A., Mercado-Sáenz, S., Burgos-Molina, A. M., Alamilla-Presuel, J. C., Alcaraz, M., Sendra‐Portero, F., & Ruiz-Gomez, M. J. (2023) · Antioxidants · doi:10.3390/antiox12091690 · Cited by 5 · see citing works

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Xie, J., Main, H. G., Suarez, J. S., Muralidhar, G. G., & Barbolina, M. V. (2018) · Oncogenesis · doi:10.1038/s41389-018-0046-6 · Cited by 5 · see citing works

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Seale, C., & Gonçalves, J. P. (2024) · Bioinformatics Advances · doi:10.1093/bioadv/vbaf157 · Cited by 4 · see citing works

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Pardo, B., Gómez‐González, B., & Aguilera, A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8740-3 · Cited by 323 · see citing works

Homologous recombination and nonhomologous end-joining repair in yeast

Jones, R. E., Durley, S. C., & Humphrey, T. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00008-8 · Cited by 1 · see citing works

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Krejčí, L., Chen, L., Komen, S. V., Sung, P., & Tomkinson, A. E. (2003) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(03)01013-4 · Cited by 66 · see citing works

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de Bragança, S., Dillingham, M. S., & Moreno‐Herrero, F. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.09.004 · Cited by 16 · see citing works

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

Sonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y., & Takeda, S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.022 · Cited by 527 · see citing works