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Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

Ishibashi, Shun, Perrey, Stáphane, Chen, Zhong, Osuga, Jun-ichi, Shimada, Masako, Ohashi, Ken, Harada, Kenji, Yazaki, Yoshio, Yamada, Nobuhiro·1996·Journal of Biological Chemistry
DOI 10.1074/jbc.271.37.22422
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FIG. 1 [ 3 H]Retinyl ester excursion in the d < 1.019 g/ml lipoprotein fractions. After overnight fasting, 200 m l of corn oil supplemented with 0.2 Bq of [ 3 H]retinol was administered to 4-5 male wild-type, 5 male LDLR( 2 / 2 ) , 4 male apoE( 2 / 2 ) , and 5 male apoE( 2 / 2 ); LDLR( 2 / 2 ) mice without anesthesia. The changes in [ 3 H]retinol in the d , 1.019 g/ml lipoproteins are shown. The values are represented as mean 6 S.D. Mean age and mean body weight of the mice at the time of the experiment was 16 weeks and 21.6 g, respectively.
FIG. 1 [ 3 H]Retinyl ester excursion in the d < 1.019 g/ml lipoprotein fractions. After overnight fasting, 200 m l of corn oil supplemented with 0.2 Bq of [ 3 H]retinol was administered to 4-5 male wild-type, 5 male LDLR( 2 / 2 ) , 4 male apoE( 2 / 2 ) , and 5 male apoE( 2 / 2 ); LDLR( 2 / 2 ) mice without anesthesia. The changes in [ 3 H]retinol in the d , 1.019 g/ml lipoproteins are shown. The values are represented as mean 6 S.D. Mean age and mean body weight of the mice at the time of the experiment was 16 weeks and 21.6 g, respectively.CC-BY · From the PDF
FIG. 2 [ 3 H]Retinyl ester excursion in lipoprotein subfractions analyzed by sequential ultracentrifugation. After overnight fasting, female mice were anesthetized by pentobarbital, and 200 m l of corn oil supplemented with 0.2 MBq of [ 3 H]retinol was administered by gastric intubation to wild-type ( E ) and the LDLR( 2 / 2 ) mice ( ● ) ( n 5 5). 50 m l of plasma from each mouse are pooled, and lipoproteins were fractionated according to the method of Redgrave and Carlson (27). Radioactivities in 200 m l of the fractionated samples are indicated. One of the wild-type mice died after 1 h of anesthesia and was excluded from the results. Mean age and mean body weight of the mice at the time of the experiment were 21.5 weeks and 24.1 g, respectively.
FIG. 2 [ 3 H]Retinyl ester excursion in lipoprotein subfractions analyzed by sequential ultracentrifugation. After overnight fasting, female mice were anesthetized by pentobarbital, and 200 m l of corn oil supplemented with 0.2 MBq of [ 3 H]retinol was administered by gastric intubation to wild-type ( E ) and the LDLR( 2 / 2 ) mice ( ● ) ( n 5 5). 50 m l of plasma from each mouse are pooled, and lipoproteins were fractionated according to the method of Redgrave and Carlson (27). Radioactivities in 200 m l of the fractionated samples are indicated. One of the wild-type mice died after 1 h of anesthesia and was excluded from the results. Mean age and mean body weight of the mice at the time of the experiment were 21.5 weeks and 24.1 g, respectively.CC-BY · From the PDF
FIG. 3 FPLC profile of [ 3 H]retinol radioactivities in plasma from the LDLR( 2 / 2 ) mice. 500 m l of corn oil supplemented with 3.7 MBq of [ 3 H]retinol was administered by gastric intubation to two male LDLR( 2 / 2 ) mice (8 months old). The plasma were pooled and aliquots were subjected to FPLC analysis. Chylo , chylomicron.
FIG. 3 FPLC profile of [ 3 H]retinol radioactivities in plasma from the LDLR( 2 / 2 ) mice. 500 m l of corn oil supplemented with 3.7 MBq of [ 3 H]retinol was administered by gastric intubation to two male LDLR( 2 / 2 ) mice (8 months old). The plasma were pooled and aliquots were subjected to FPLC analysis. Chylo , chylomicron.CC-BY · From the PDF
FIG. 4 Agarose gel electrophoresis of the lipoprotein fractions from the mice fed a normal chow. Blood was collected from the wild-type, LDLR( 2 / 2 ) , apoE( 2 / 2 ) and apoE( 2 / 2 );LDLR( 2 / 2 ) mice fed a normal chow ( n 5 3). Equal volume of the plasma from three mice of each genotype was mixed, and 25 m l of it was used for the ultracentrifugation. 10 m l of each lipoprotein fraction of chylomicron ( Chylo ) through HDL was subjected to agarose gel electrophoresis. The gels stained with Fat Red 7B were shown.
FIG. 4 Agarose gel electrophoresis of the lipoprotein fractions from the mice fed a normal chow. Blood was collected from the wild-type, LDLR( 2 / 2 ) , apoE( 2 / 2 ) and apoE( 2 / 2 );LDLR( 2 / 2 ) mice fed a normal chow ( n 5 3). Equal volume of the plasma from three mice of each genotype was mixed, and 25 m l of it was used for the ultracentrifugation. 10 m l of each lipoprotein fraction of chylomicron ( Chylo ) through HDL was subjected to agarose gel electrophoresis. The gels stained with Fat Red 7B were shown.CC-BY · From the PDF
Image 5
CC-BY · From the PDF
FIG. 6 Disappearance of 125 I-labeled rat chylomicron remnants from the circulation of wild-type ( E ) and the LDLR( 2 / 2 ) ( ● ) mice. 20 m g of 125 I-labeled rat chylomicron remnants (specific activity, 520 cpm/ng) were injected into the jugular vein of wild-type ( E ) and the LDLR( 2 / 2 ) ( ● ) mice ( n 5 7). The blood samples were taken at the indicated times. The apoB-associated radioactivities were measured and shown as % of the injected dose. The values are mean 6 S.D. Mean age and mean body weight of the mice at the time of the experiment were 22 weeks and 28 g, respectively. *, p , 0.05, compared with wild-type mice fed a normal chow.
FIG. 6 Disappearance of 125 I-labeled rat chylomicron remnants from the circulation of wild-type ( E ) and the LDLR( 2 / 2 ) ( ● ) mice. 20 m g of 125 I-labeled rat chylomicron remnants (specific activity, 520 cpm/ng) were injected into the jugular vein of wild-type ( E ) and the LDLR( 2 / 2 ) ( ● ) mice ( n 5 7). The blood samples were taken at the indicated times. The apoB-associated radioactivities were measured and shown as % of the injected dose. The values are mean 6 S.D. Mean age and mean body weight of the mice at the time of the experiment were 22 weeks and 28 g, respectively. *, p , 0.05, compared with wild-type mice fed a normal chow.CC-BY · From the PDF

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Cites

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Metadata

Authors
Ishibashi, S., Perrey, S., Chen, Z., Osuga, J.-I., Shimada, M., Ohashi, K., Harada, K., Yazaki, Y., & Yamada, N.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1996-09
Volume
271
Issue
37
Pages
22422-22427
ISSN
0021-9258
DOI
10.1074/jbc.271.37.22422
Cited by
106
References
3
Language
en
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